A5101498498- Porphyrin Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Estrogen and related hormone effects
- Congenital heart defects research
- Folate and B Vitamins Research
- Pulmonary Hypertension Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vitamin D Research Studies
- Spondyloarthritis Studies and Treatments
- Genomic variations and chromosomal abnormalities
- Neurological and metabolic disorders
- Advances in Oncology and Radiotherapy
- Autoimmune Bullous Skin Diseases
- Reproductive System and Pregnancy
- Thyroid Cancer Diagnosis and Treatment
- Vasculitis and related conditions
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Quality Function Deployment in Product Design
- Cardiac and Coronary Surgery Techniques
- interferon and immune responses
- Cancer Risks and Factors
- Inflammasome and immune disorders
- Neurological Complications and Syndromes
- Neurological Disease Mechanisms and Treatments
First Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2025
Fujian Medical University
2024
National and Kapodistrian University of Athens
2024
Roma Tre University
2024
University of Chieti-Pescara
2024
Peking Union Medical College Hospital
2015-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Beijing Friendship Hospital
2023
Capital Medical University
2011-2023
Abstract Background This study was performed to analyze the clinical manifestations, imaging features, and prognosis of Takayasu’s arteritis (TA) with pulmonary (PA). Methods In total, 51 815 patients TA were diagnosed PA at Peking Union Medical College Hospital from 1986 2015. The patients’ medical records radiographic data retrospectively reviewed. Results comprised 39 women 12 men a median age 33 years (range, 14–67 years). most common symptoms dyspnea (70.6%), cough (66.7%), hemoptysis...
Objective Although several studies have examined the relationship between thyroid function and muscle strength, their population primarily derived from Asian areas, results were controversial. Thus, this study aimed to explore association handgrip strength (HGS) in U.S. population. Methods A total of 1,067 participants NHANES categorized into three different age groups including young (<45 years), middle (45~64 old (≥65 years) groups. Thyroid was measured by competitive binding...
Abstract Aim The objective of this study was to evaluate the impact rheumatoid arthritis ( RA ) on physical function and health‐related quality life HRQ oL) in China. Method A cross‐section survey conducted 21 general hospitals Eight hundred seven patients were recruited. Data demographics, clinical data, (Stanford Health Assessment Questionnaire Disability Index, HAQ ‐ DI oL (Study Short Form 36 Survey, SF ‐36) collected site. Results In our cohort, impaired 77.6% >0). median...
Porphyria is a group of eight metabolic disorders characterized by defects in heme biosynthesis. The presentation porphyria highly variable, and the symptoms are nonspecific, which accounts part for delays establishing diagnosis. In this study, we report characteristics 36 Chinese acute patients. Most them were female (33/36), median age was 25.3 years (range 18–45 years). most frequent presenting symptom abdominal pain (32/36). Hyponatremia common electrolyte abnormality (29/36), serum...
Abstract Clinical Treatment Score post-5 years (CTS5) is a promising prognostic tool to evaluate late recurrence risk for breast cancer. Our study aimed validate its value in large-scale population and explore the impact of menopausal HER2 status on CTS5 model. We performed retrospective cohort using Surveillance, Epidemiology, End Results (SEER) database. Survival analyses were conducted assess different cancer subgroups terms overall survival (OS) specific (BCSS) after five years. A total...
Background . Acute intermittent porphyria (AIP) is an autosomal recessive disorder with attacks. Patients AIP are susceptible to impaired quality of life and psychological distress. Objectives To document the clinical features its impact on SF-36 IES scores patients in China explore variables associated scores. Methods A single investigator collated data related treatments outcomes 27 PUMCH. cross-sectional questionnaire survey including SF-36, IES-R, demographic questions was conducted...
Several studies have evaluated the association between statin use and endometrial cancer risk. We carried out a meta-analysis of randomized controlled trials (RCTs) non-randomized to evaluate effect statins on A comprehensive search electronic databases, conference abstracts clinical trial registers was conducted for published unpublished results. Studies that exposure risk were considered. Pooled relative risks (RRs) with 95% confidence intervals (CIs) calculated using either fixed-effects...
Abstract Background Initiating ivabradine in acute heart failure (HF) is still controversial. Hypothesis Ivabradine might be effective to added but hemodynamically stable HF. Methods A retrospective cohort of HF patients was enrolled from January 2018 2020 and followed until July 2020. The primary endpoints were all‐cause mortality rehospitalization for Secondary included rate (HR), cardiac function measured by New York Heart Association (NYHA) class, left ventricular ejection fraction...
Thrombocytopenia is one of the most common complications cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT RIT, respectively). Caulis Polygoni Multiflori (CPM), commonly used Chinese herbs, has been well documented nourish blood for tranquilizing mind treating anemia, suggesting its beneficial effect on hematopoiesis. However, it unknown whether CPM can accelerate megakaryopoiesis thrombopoiesis. Here, we...
The time-velocity integral of the left ventricular outflow tract (TVILVOT) has been demonstrated to correlate with heart failure hospitalization and mortality, but association TVILVOT severity prognosis pulmonary arterial hypertension (PAH) not evaluated.The aim this study was investigate predictive value baseline in PAH.A total 225 consecutive patients a diagnosis incident PAH were prospectively studied echocardiology-derived measured at enrollment followed by right catheterization...
Objective: To analyze the clinical characteristics and molecular mechanisms of 5 cases hypoparathyroidism caused by GATA3 gene mutation. Methods: A total childhood-onset patients with mutation were identified from 198 (aged ≤18 years) 1975 to 2021 in Peking Union Medical College Hospital. Clinical data biochemical indices collected analyzed retrospectively. Genetic screening was conducted targeted next-generation sequencing (T-NGS), bioinformatics analysis performed underline mechanisms....
A description of the contents, indexes, and method appropriateness for supervision appraisal tobacco control management in hospitals, an insight on regularity effectiveness building tobacco-free hospitals. The dual indexes intervention outcome were ascertained from both dimensions process effect; terms methodology, paper described time focus, areas, priority objects, population supervision, penalty, as well conditional support appraisal. It is pointed out that timely summary appraisal,...
Objective To investigate the blood-saving effect of tranexamic acid in off-pump coronary artery bypass (OPCAB). Methods Two hundred and sixty ASA Ⅰ- Ⅲ NYHA patients both sexes,aged 18-64 yr, with body mass index 16-22 kg/m2 , undergoing OPCAB, were randomly divided into 2 groups (n = 130 each): control group (group C) T) . Anesthesia was induced iv injection midazolam 0.1 mg/kg, fentanyl 5-10μg/kg pipecuronium mg/kg. The tracheal intubated mechanically ventilated. PEr CO2 maintained at 35-45...
Abstract Purpose: Large genic copy number variations (CNVs) that are rare in the general population have been identified as pathogenic many human diseases. Microdeletion of chromosome 22 leads to DiGeorge syndrome-1 (DGS-1), however, research on influence CNVs phenotype DGS-1 related hypoparathyroidism (HP) is still lacking. To understand CNV profiles whole genome and their correlation with HP a series patients by CNV-sequencing. Methods: were detected low-depth sequencing. The clinical data...
Abstract Maternal-fetal interface shares similarities with tumor tissues in terms of immune microenvironment. Normal pregnancy is maintained due to the immunosuppressed state, but pyroptosis induced by MITA can trigger body's response and disrupt state maternal-fetal interface, leading abortion. In this study, we explored role TRIM38 regulating maintaining tolerance during pregnancy. Our findings show that interaction between plays a crucial interface. Specifically, observed TRIM38-mediated...