An extremely convenient method for deprotection of acetals and ketals catalyzed by molecular iodine (10 mol %) in acetone is reported. The protocol achieved the acyclic or cyclic O,O-acetals O,O-ketals excellent yields within a few minutes under neutral conditions. double bond, hydroxyl group, acetate group remained unchanged, highly acid-sensitive furyl, tert-butyl ethers, ketone-oxime stayed intact these

The catalytic asymmetric cyclopropanation reaction of alkenes with diazo compounds is a direct and powerful method to construct chiral cyclopropanes that are essential drug discovery. However, potentially explosive often require hazardous reagents for their preparation. Here, we report on the use 1,2-dicarbonyl as safe readily available surrogates in deoxygenative reaction. Enabled by class simple accessible salen-Mo catalysts, proceeded generally good enantioselectivities yields toward wide...

A nonenzymatic iron-catalyzed dehydrogenative kinetic resolution of cyclic secondary amines using air as an oxidant has been reported. The economical and practical method is applicable to a series benzylic amines, including 5,6-dihydrophenanthridines 1,2-dihydroquinolines, with diverse functional groups at the α position in high yields excellent enantioselectivities. direct advanced intermediates bioactive molecules that are difficult access existing catalytic asymmetric synthetic strategy...

Abstract The transition‐metal‐catalyzed cyclopropanation of alkenes by the decomposition diazo compounds is a powerful and straightforward strategy to produce cyclopropanes, but tempered potentially explosive nature substrates. Herein we report Mo‐catalyzed regiospecific deoxygenative readily available bench‐stable 1,2‐dicarbonyl compounds, in which one two carbonyl groups acts as carbene equivalent upon deoxygenation engages subsequent process. use commercially Mo catalyst afforded an array...

Background: The purpose of this study is to identify and characterize ocular adverse events (AEs) that are significantly associated with anti-VEGF drugs for treatment neovascular age-related macular degeneration compare the differences between each drug, provide clinical reference. Methods: Ocular AEs submitted US Food Drug Administration were analyzed map safety profile drugs. Pharmacovigilance tools used quantitative detection signals reporting odds ratio bayesian confidence propagation...

A novel approach to medium-sized cyclic ethers was devised using a Stevens [1,2]-shift of sulfonium ylide derived from readily accessible six-membered mixed-monothioacetal precursor. The concise and efficient transformation offers surprising degree chirality transfer with observed retention stereochemical configuration on the anomeric migrating carbon has been applied as key step in an enantioselective formal synthesis (+)-laurencin.

Background Oral anticoagulation (OAC) following catheter ablation (CA) of nonvalvular atrial fibrillation (NVAF) is essential for the prevention thrombosis events. Inappropriate application OACs does not benefit stroke but may be associated with a higher risk bleeding. Therefore, this study aims to develop clinical data-driven machine learning (ML) methods predict and bleeding establish more precise strategies patients NVAF. Methods Patients NVAF who underwent CA therapy were enrolled from...

One-pot synthesized CsPbBr₃ PNC-polystyrene pre-polymer enables solvent- and initiator-free fabricating efficient stable micropatterned thin films. This method provides a bright prospect for PNC-PS composites in display application.

Here, we report a Mo-catalyzed carbonyl–carbonyl olefination reaction for the syntheses of several heterocycles, such as indoles, benzofurans, benzothiophene, 2-pyrone, coumarins and their derivatives.

At present, the remediation for organic pollutants and heavy metals co-contaminated soils is a challenge which needs to be broken through. In this study, alkyl polyglucoside (APG), citric acid (CA), nitrilotriacetic (NTA) were chosen enhance phytoremediation of pyrene Pb by perennial ryegrass. Through comparison results with different applications, it could found that application NTA was beneficial growth ryegrass, underground aboveground biomass increased 172.9-236.1% 61.9-142.8%,...

Fundamental insights into the reaction kinetics of organic-inorganic lead halide perovskite nanocrystals (LHP NCs) are still limited due to their ultrafast formation rate. Herein, we develop a water-oil interfacial synthesis MAPbBr3 NCs (MA=CH3 NH3+ ), which prolongs time tens minutes. This method makes it possible monitor in situ process and observe successive spectral evolutions from 438 534 nm single by extending time. The implementation this depends on reducing rate PbBr64- octahedra...

Antimicrobial resistance, a major threat to human health, is mainly driven by the overuse of antimicrobials. The purpose this study was further investigate relationship between antimicrobial use and resistance with 15-year record in Southwest hospital, one largest hospitals China university affiliated thus predict an autoregressive integrated moving average (ARIMA) manner. Kirby-Bauer tests were carried out figure drug sensitivity Gram-negative bacterial. Antimicrobials (β-lactamase...

A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- C-acylation 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair structural isomers 2-aryl pyrido[2,1-a]isoindole-4,6-diones 4-aryl 1-methyl-1H-indeno[1,2-b]-pyridine-2,5-diones, as potential inhibitors tumor cell proliferation, were prepared respectively.