A5046676286- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Analysis
- Nosocomial Infections in ICU
- Pharmaceutical studies and practices
- Neonatal Respiratory Health Research
- Natural product bioactivities and synthesis
- Biosimilars and Bioanalytical Methods
- Energy, Environment, Economic Growth
- Sexual function and dysfunction studies
- Antimicrobial Peptides and Activities
- Food Quality and Safety Studies
- Innovation Diffusion and Forecasting
- Bacterial biofilms and quorum sensing
- Medical and Biological Ozone Research
- Pediatric Pain Management Techniques
- Ocular Infections and Treatments
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Medicinal Plants and Neuroprotection
- Pneumocystis jirovecii pneumonia detection and treatment
- Click Chemistry and Applications
- Child Development and Education
Army Medical University
2013-2025
Sun Yat-sen University
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Southwest Hospital
2005-2023
Taichung Veterans General Hospital
2015-2017
Affiliated Hospital of Taishan Medical University
2014
Southwest General Health Center
2012
T-DM1 and T-DXd are two promising antibody-drug conjugates for treating advanced HER2-positive breast cancer HER2-mutated lung cancer. Understanding the differences in adverse events (AEs) profile of both drugs may help clinicians make an appropriate treatment decision.All data obtained from FDA Adverse Event Reporting System (FAERS) database Q1 2004 to Q3 2022 underwent disproportionality analysis Bayesian detect assess AE signals comparison.A total 2,113 1,269 reports associated with...
Metabolic reprogramming in tumor-associated macrophages (TAM) is associated with cancer development, however, the role of macrophage triglyceride metabolism metastasis unclear. Here, we showed that TAMs exhibited heterogeneous expression abhydrolase domain containing 5 (ABHD5), an activator hydrolysis, migratory expressing lower levels ABHD5 compared nonmigratory TAMs. inhibited cell migration vitro xenograft models and genetic models. The effects on were dissociated from its metabolic...
To establish an optimal model to predict the teicoplanin trough concentrations by machine learning, and explain feature importance in prediction using SHapley Additive exPlanation (SHAP) method.A retrospective study was performed on 279 therapeutic drug monitoring (TDM) measurements obtained from 192 patients who were treated with intravenously at First Affiliated Hospital of Army Medical University November 2017 July 2021. This included 27 variables, considered as target variable. The whole...
Aims To establish a population pharmacokinetic (PopPK) model of polymyxin B (PMB) in critically ill patients based on steady-state trough (C trough,ss ) and peak peak,ss concentrations, optimize the dosing regimen, evaluate consistency 24-hour area under concentration-time curve (AUC ss,24h estimation between model-based two-point C methods. Methods PopPK modeling was performed using NONMEM, Monte Carlo simulations were used to PMB regimens. Bland-Altman analysis two AUC Results A total 95...
Background: The purpose of this study is to identify and characterize ocular adverse events (AEs) that are significantly associated with anti-VEGF drugs for treatment neovascular age-related macular degeneration compare the differences between each drug, provide clinical reference. Methods: Ocular AEs submitted US Food Drug Administration were analyzed map safety profile drugs. Pharmacovigilance tools used quantitative detection signals reporting odds ratio bayesian confidence propagation...
Hospital-acquired infections are a leading cause of morbidity and mortality in neonatal intensive care units (NICU). The aim the study was to investigate change nosocomial infection rate NICU during 4-year surveillance period.We investigated changes rates, sites, microorganism species before after unit moved new location, extending from November 2008 October 2012.The facility opened on 1, 2010 old closed same day. In meantime, three catheter-based bundles were implemented all our hospital...
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen in hospital-acquired infection and readily able to form biofilms. Due its high antibiotic resistance, traditional antibacterial treatments exert limited effect on P. biofilm infections. It has been indicated that hyperoside inhibits PAO1 (PAO1) formation without affecting growth. Therefore, the current study examined quorum sensing (QS) system of presence hyperoside. Confocal laser scanning microscopy analysis demonstrated...
Abstract Background Teicoplanin has been widely used in patients with infections caused by Staphylococcus aureus, especially for critically ill patients. The pharmacokinetics (PK) of teicoplanin vary between individuals and within the same individual. We aim to establish a prediction model via combination machine learning population PK (PPK) support personalized medication decisions Methods A retrospective study was performed incorporating 33 variables, including PPK parameters (clearance...
Abstract Background The "Law on Doctors of the People's Republic China," which was officially implemented March 1, 2022, emphasizes requirements for rational drug use and necessity appropriate management off-label use. safety ethical considerations related to are different in children than adults. There is so far no guideline pediatric drugs China, applicability foreign guidelines limited. Establishing a localized evidence-based support national legislation clinical practice critical...
The goal of the studies presented here was to determine tolerability, pharmacokinetic and pharmacodynamic profiles CMAB007, a biosimilar omalizumab (Xolair; humanized anti-immunoglobulin E monoclonal antibody), in healthy, male Chinese subjects. Thirty-six healthy men participated two open-label, dose-escalation studies: 27 single-dose study (150, 300 or 600 mg) 9 multiple-dose (150 mg every 4 weeks for 20 weeks). safety both were generally unremarkable. No drug-related adverse event...
Effects of CYP2C19 polymorphism on voriconazole concentration (C0 ), dose-adjusted trough concentrations /dose) and voriconazole-to-voriconazole-N-oxide ratio /CN ) have not been fully investigated.To investigate correlations polymorphisms with plasma the major metabolite voriconazole-N-oxide in elderly patients.A prospective, multi-centre, non-intervention, open clinical study was conducted within Southwestern Chinese patients clinically diagnosed invasive fungal infections, to associations...
Background Voriconazole (VCZ) is a first-line treatment drug for invasive fungal disease, with narrow therapeutic window and significant inter-individual variability. VCZ primarily metabolized by liver, which declines age. For elderly patients, physiological pathological factors lead to more pronounced fluctuations in plasma concentrations. Thus, it crucial establish model that accurately predicts concentration patients. Methods A retrospective study was performed incorporating 32 variables,...
Antimicrobial resistance, a major threat to human health, is mainly driven by the overuse of antimicrobials. The purpose this study was further investigate relationship between antimicrobial use and resistance with 15-year record in Southwest hospital, one largest hospitals China university affiliated thus predict an autoregressive integrated moving average (ARIMA) manner. Kirby-Bauer tests were carried out figure drug sensitivity Gram-negative bacterial. Antimicrobials (β-lactamase...
This study investigates the impact of well-being on carbon efficiency in entertainment market from perspective geographic psycholinguistics. To analyze this impact, we employ quantile regression based method moments and spatial econometric models that incorporate economic policy uncertainty. The results highlight substantial energy conservation emission reduction. On one hand, our findings indicate significantly reduces emissions exhibits a externality effect. Furthermore, indirectly...
Voriconazole (VRZ) is the recommended standard treatment for life-threatening invasive aspergillosis. The plasma concentration of VRZ should be determined to optimise results and reduce side effects. This study aimed compare correlation concordance ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) enzyme-multiplied immunoassay technique (EMIT) determine in clinical practice.An isotopically labelled internal UPLC-MS/MS method was established, validated,...
To develop a population-based pharmacokinetic model for the oral antiepileptic drug zonisamide using cohort of healthy (nonepileptic) subjects and evaluate effect individual factors on pharmacokinetics zonisamide. 30 young adults (21-39 years) in good health were randomly assigned to 3 equal groups (1:1 sex ratio) single-dose administration at 200 mg, 300 or 400 mg. An additional 9 (22-24 administered once daily mg 14 days, comprised multiple dosing group. Venous blood samples collected...
Purpose Cancer often coexists with erectile dysfunction, yet the causal relationship between them remains unclear. This study aims to investigate link tumors and ED through Mendelian randomization. Method Data on 13 different cancers, including lung cancer, colorectal testicular lymphoma, esophageal pancreatic thyroid bladder cancer brain were collected from various databases. data, comprising 2,205 cases 164,104 controls, sourced FinnGen project. Primary methods for MR analysis included...