A5102771544- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Hydrocarbon exploration and reservoir analysis
- Hydraulic Fracturing and Reservoir Analysis
- Risk and Safety Analysis
- Abdominal Surgery and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Reservoir Engineering and Simulation Methods
- Pediatric Hepatobiliary Diseases and Treatments
- Methane Hydrates and Related Phenomena
- COVID-19 Clinical Research Studies
- Appendicitis Diagnosis and Management
- Viral-associated cancers and disorders
- Regional Economic and Spatial Analysis
- Drilling and Well Engineering
- SARS-CoV-2 and COVID-19 Research
- Pediatric Pain Management Techniques
- Grey System Theory Applications
- Cancer Diagnosis and Treatment
- Electromagnetic Launch and Propulsion Technology
- Islamic Finance and Banking Studies
- COVID-19 and healthcare impacts
- Heat shock proteins research
- ATP Synthase and ATPases Research
China University of Petroleum, Beijing
2025
Lanzhou University
2017-2024
First Hospital of Lanzhou University
2017-2024
University of California, Irvine
2022
China International Science and Technology Cooperation
2020
University College London
2020
Great Ormond Street Hospital
2020
Tianjin University of Commerce
2010-2011
Curcumol is the major component extracted from root of Rhizoma Curcumae. Recent studies have shown that curcumol exerts therapeutic effects against multiple conditions, particularly cancers. However, role and mechanism cholangiocarcinoma cells are still unclear. In our current research, we tested effect in cells, using two-dimensional electrophoresis, proteomics bioinformatics, identified cyclin-dependent kinase like 3 (CDKL3) as a potential target for curcumol. We demonstrated can evidently...
Background: To clarify the characteristic and duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children. Methods: A total 32 confirmed SARS-CoV-2 infection between January 24 February 12, 2020 from four provinces western China were enrolled this study followed up until discharge quarantine 14 days later. Results: Eleven (34%) asymptomatic, among whom six had normal computed tomographic (CT) scan...
Heat shock protein 90 (Hsp90) is a promising target for cancer therapy and imaging. Accurate detection of Hsp90 levels in tumors via noninvasive PET imaging might be beneficial management. To achieve this, the precursor compound Dimer-Sansalvamide A (Dimer-San A) was PEGylated modified by conjugating it with bifunctional chelator 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). The
A numerical analysis model for sand-mudstone interbedded fracturing based on field application in South China is presented this paper. The proposed can analyze the influence laws of different longitudinal lithology changes, stress difference interlayer positions, and fluid construction parameters fracture characteristics. Based study characteristics low-modulus mudstone, a set layered loading experimental devices was independently designed developed. Experimental shows that has limited...
Based on the research of formation mechanism and evolution rule hydrate flow obstacle during deep-water gas well testing, a new method for prevention based safety testing window is proposed by changing previous idea "preventing formation" to "allowing formation, preventing plugging". The results show that effective inner diameter tubing wellhead pressure decrease gradually with precipitation hydrates it presents three typical processes slow, fast sudden changes. There testing. decreases...
Abstract Background The "Law on Doctors of the People's Republic China," which was officially implemented March 1, 2022, emphasizes requirements for rational drug use and necessity appropriate management off-label use. safety ethical considerations related to are different in children than adults. There is so far no guideline pediatric drugs China, applicability foreign guidelines limited. Establishing a localized evidence-based support national legislation clinical practice critical...
Background & Aims: Cholangiocarcinoma (CCA) patients have poor outcomes since the late diagnosis limits benefits of surgery therapy and curative treatment options. The present study was designed to screen biomarkers for CCA patients. Methods: Quantitative iTRAQ proteomic analysis used identify differentially expressed proteins between pericarcineous tissue. We examined expression profile PRDX2, BGN, LUM, PPP3CA in tissue using immunohistochemistry. further investigated correlation survival...
Hydrate formation risk is an important challenge in the development of deep-water gas field. Considering characteristics Lingshui (LS) field South China Sea and difference well structures, a model for calculating wellbore temperature pressure production proposed verified by data. Combining hydrate equilibrium models with varied components, prediction method region obtained. The regions under different operating conditions were given model. results show that no exists operation, but shut-in...
Deepwater gas well testing in the South China Sea is characterized by high difficulty, investment and risk. In order to reduce effectively risk of operation Sea, potential factors deepwater were analyzed 42 categories identified. The fault tree analysis method was used establish model for a well, analyze inter restricted relationship between risks. Combining with hierarchical calculate weight values evaluation indicators use product it probability importance as corrected value occurrence...