A5001644557- Marine Sponges and Natural Products
- Microscopic Colitis
- Inflammatory Bowel Disease
- Microbial Natural Products and Biosynthesis
- Seaweed-derived Bioactive Compounds
- Diverticular Disease and Complications
- Plant-derived Lignans Synthesis and Bioactivity
- Intestinal Malrotation and Obstruction Disorders
- Congenital gastrointestinal and neural anomalies
- Chemical Synthesis and Analysis
- Bioactive Compounds and Antitumor Agents
- Autoimmune and Inflammatory Disorders
- Phytochemistry and Biological Activities
- Ferroptosis and cancer prognosis
- Eosinophilic Esophagitis
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- RNA Research and Splicing
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Intestinal and Peritoneal Adhesions
- Pneumonia and Respiratory Infections
- Echinoderm biology and ecology
- Esophageal and GI Pathology
Nanjing University
2022
Nanjing General Hospital of Nanjing Military Command
2022
Nanchang University
2021
Fuzhou University
2021
Qingdao National Laboratory for Marine Science and Technology
2019
Ocean University of China
2004-2013
657 Oslo
2013
Southwest Hospital
2005
Army Medical University
2005
Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures elucidated as (−)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)-phenyl]-1-nonanone (1) (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3′-methoxy-8-methyl-1′-(E-propenyl)benzofuran (2). In addition, absolute configuration (+)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (3) was determined for first time through spectroscopic chemical methods. Their antioxidative activities...
Four new furofurano lignans, lantibesides B - D ( 1 3) and lantibetin 4), along with nine known phenolic compounds were isolated from the EtOH extract of traditional Tibetan medicinal plant, Lancea tibetica. By means spectroscopic chemical methods, structures elucidated as (1 R,2 S,5 R,6 S)-2-(3,4-methylenedioxyphenyl)-6-[(3-methoxy-4-beta- D-xylopyranosyloxy(1-->6)-beta- D-glucopyranosyloxy)phenyl]-3,7-dioxabicyclo[3.3.0]octane 1), R,5 D-glucopyranosyloxy)phenyl]-3,7-dioxabicyclo...
的细胞毒活性, 结果表明: 化合物 1～5 对上述人癌细胞具有细胞毒活性, 其半数抑制浓度(IC 50 )为 0.1～9.7 μmol•L -1 ; 新化合物 1 对 L-02 的毒性较低, 但对 Jurkat、HCT-116 和 BXPC-3 的选择指数(SI)分别高达 31.5、41.1 52.4.除化合 物 2 3 A549 MCF
PRAS40 (Prolin-rich Akt substrate of 40 kDa) is a critical protein, which directly connects PI3K/Akt and mTORC1 pathway. It plays an indispensable role in the development various diseases. However, relationship between head neck squamous cell carcinoma (HNSCC) remains unclear. Here, our study indicated that high expression mRNA favorable prognostic factor HNSCC patients by analyzing 498 clinical data. Moreover, we confirmed CRISPR/Cas9 induced PRAS40-knockout would promote colony formation,...
Three new sulfated alkenes (1−3), trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, dimethylammonium and 2'-methyl-4'-oxobutan-2-ylammonium were isolated from an echinoderm, Temnopleurus hardwickii. Their structures elucidated by spectral analysis chemical degradation methods.
Background/Aims: The aim of this study was to analyze the chronological changes in postoperative complications surgical ulcerative colitis patients over past decade China and investigate potential parameters that contributed changes. Methods: Ulcerative who underwent surgery during 2008–2017 were retrospectively enrolled from 13 hospitals China. Postoperative compared among different operation years. Risk factors for identified by logistic regression analysis. Results: A total 446 analyzed....
Despite advances in medical therapy for Crohn's disease (CD), most patients with CD require repeated resection surgeries.