A5100392679- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Liver Diseases and Immunity
- Genomic variations and chromosomal abnormalities
- Hepatocellular Carcinoma Treatment and Prognosis
- Prenatal Screening and Diagnostics
- ATP Synthase and ATPases Research
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Maternal Mental Health During Pregnancy and Postpartum
- Hedgehog Signaling Pathway Studies
- Hepatitis B Virus Studies
- Grief, Bereavement, and Mental Health
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Traditional Chinese Medicine Analysis
- Machine Learning in Healthcare
- Cancer Mechanisms and Therapy
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Macrophage Migration Inhibitory Factor
- Enzyme function and inhibition
- Fetal and Pediatric Neurological Disorders
Tongji University
2015-2025
General Hospital of Shenyang Military Region
2025
Shanghai East Hospital
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Xi'an Jiaotong University
2024
Xuzhou Medical College
2017-2020
Xuzhou Central Hospital
2020
Nanjing Medical University
2020
Shanghai Tenth People's Hospital
2016-2019
Hospital of Hebei Province
2019
Abstract The aim of this study was to investigate the effect quercetin on hepatic fibrosis, a characteristic response acute or chronic liver injury. Mice were randomized bile duct ligation (BDL) carbon tetrachloride (CCl 4 ) cirrhosis models. Quercetin (100 mg/kg 200 daily) administered by gavage for 2 weeks. Liver tissue and blood samples collected histological molecular analysis. results our experiments showed that reduced BDL CCl inhibited extracellular matrix formation, regulated...
Fear of childbirth may affect delivery experience and postpartum recovery, even lead to depression. Spouses, as the primary caregivers pregnant women, are an important source emotional support have a significant impact on their psychological adjustment. The aim this study is explore association fear depression with perceived partner response during pregnancy. A longitudinal was conducted at Northern Theater Command General Hospital from June 2023 April 2024. 289 women completed two surveys...
Abstract Background Liver fibrosis is a wound‐healing process of liver featured by the over‐deposition extracellular matrix (ECM) and angiogenesis. However, effective treatment lacking. Procyanidin B2 (PB2) flavonoid extract abundant in grape seeds with anti‐oxidant, anti‐inflammatory anti‐cancer properties. The present study aimed to determine effects PB2 on fibrosis. Method CCl4‐induced mouse model human hepatic stellate cell (HSC) line (LX2 cells) were used activation, ECM production...
Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to cirrhosis. Shikonin extracted from root Lithospermum erythrorhizon with antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The study aims investigate protective effect shikonin on its underlying mechanism.Two models were established in male C57 mice by intraperitoneal injection CCl4 or bile duct ligation. was administered orally three times weekly at dose 2.5 5 mg/kg....
<title>Abstract</title> <bold>Background</bold> Sepsis, a life-threatening organ dysfunction resulting from dysregulated host response to infection, remains major global health challenge with high morbility and mortality. Current diagnostic management frameworks still lack the satisfied sensitivity specificity for early detection personalized treatment. In this study, we aim evaluate efficacy of MedGo-Sepsis, novel large language model developed by our collaborating team us that integrates...
Circulating biomarkers for sepsis are lacking, and research on circular RNAs (circRNAs) as potential of pneumonia-induced is limited. This study aims to investigate the diagnostic prognostic circRNAs in patients with sepsis. prospective cohort included 40 healthy individuals, 60 pneumonia, 80 CircRNAs identified through RNA-sequencing were validated using quantitative real-time polymerase chain reaction (qRT-PCR). Spearman correlation analysis was used evaluate associations between circRNAs,...
ATP1B3 encodes the β3 subunit of Na+/K+-ATPase and is located in q22-23 region chromosome 3. participates normal cellular activities but also plays a crucial role carcinogenesis. In present study, we found that expression was increased human gastric cancer tissues compared with matched this predicted poor outcome. elevated at both mRNA protein levels cell lines relative to those epithelial line. Interestingly, knockdown significantly inhibited proliferation, colony-formation ability,...
Rosmarinic acid (RA) is a phenolic originally isolated from the herb medicine Rosmarinus officinalis. The purpose of this study was to identify metabolites RA. RA incubated with human liver microsomes in presence β-nicotinamide adenine dinucleotide phosphate tetrasodium salt and/or uridine diphosphate glucuronic using glutathione (GSH) as trapping agent. After 60-min incubation, samples were analyzed high-resolution liquid chromatography tandem mass spectrometry. Under current conditions, 14...
In recent years, the noninvasive serological scoring system has become a research hotspot in predicting hepatic fibrosis and achieved good results. However, it rarely been applied to prediction of oesophageal varices. The aim study was evaluate predictive value four following systems cirrhosis combined with varices: aspartate platelet ratio index (APRI), aminotransferase-alanine aminotransferase (AAR), FIB-4, S index.A total 153 patients were categorized into groups or without addition,...
Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment correlations among ammonia, hemodynamics, cognitive function. Methods . There were four groups: healthy controls (group 1), cirrhosis without 2), MHE 3), OHE 4). Ammonia (by TCD) assessed. Patients group 3 subsequently randomized two subgroups: the control A) treated B, lactulose for months), they retested ammonia TCD after treatment. Results. Ammonia,<mml:math...
Background: Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) rs8099917 has been described to be associated with response treatment pegylated interferon and ribavirin (PEG-IFN/RBV) in patients chronic hepatitis C from the North America, Europe, Asia countries like Japan Taiwan. Whether this holds true for Chinese remains unknown. Objectives: We aimed study effects of IL28B on antiviral therapy responses C. Patients Methods: was genotyped 263 virus (HCV) infection 244 healthy...
Purpose: To compare overall survival (OS) and progression-free (PFS) between microwave ablation (MWA) transarterial chemoembolization (TACE) for solitary hepatocellular carcinoma (HCC) smaller than 5 cm. Methods: Patients with HCC 5cm who initially underwent MWA or TACE were identified in Chinese PLA General Hospital from June 2010 to October 2015. Propensity score matching (PSM) was performed a 1:1 protocol. OS PFS compared by using the log-rank test. After matching, subgroup analysis based...
β-blockers are commonly used for the treatment of acute variceal bleeding in cirrhosis. Renin-angiotensin-aldosterone antagonists (angiotensin I-converting enzyme inhibitors, angiotensin receptor blockers and aldosterone antagonists) potential therapies portal hypertension. Several studies have compared renin-angiotensin-aldosterone system (RAAS) inhibitor β‑blocker combination therapy vs. β-blocker monotherapy, with inconsistent results. The aim present study was to assess efficacy RAAS...
Abstract The concomitant occurrence of 8q duplication and 13q deletion is the first to be detected by noninvasive prenatal testing (NIPT) date. Through case analysis, we could provide a clinical approach pregnant women with chromosomal abnormalities revealed NIPT. combination traditional karyotype copy number variation sequencing (CNV‐seq) better locate abnormal region further identify source fetal abnormalities. Simultaneously, evaluated morphology ultrasound examination. fetus was...
Carriers of balanced reciprocal chromosomal translocations are at known reproductive risk for offspring with unbalanced genotypes and resultantly abnormal phenotypes. Once fertilization a translocation gamete normal gamete, the partial monosomy or trisomy embryo will undergo abortion, fetal arrest malformations. We reported woman who had two adverse pregnancies. Prenatal diagnosis was made her third pregnancy to provide genetic counseling guide fertility. presented three Routine G banding...
Abstract Aim Tumor budding (TB) has excellent prognostic value in many solid tumors, but there is little research on it hepatocellular carcinoma (HCC). This study assessed the of TB patients with HCC who received hepatectomy. Methods retrospective included 210 curative hepatectomy at First Affiliated Hospital Xi'an Jiaotong University, between 2016 and 2018. was evaluated hematoxylin‐ eosin‐stained slides according to criteria established by International Budding Consensus Conference. t...
The aim of the present study was to explore clinical value urinary retinol-binding protein (RBP) level in prognosis cirrhotic ascites by assessment RBP levels prior and following treatment. RBP, microalbumin (mAlb), serum urea nitrogen (urea) creatinine (Cr), estimated glomerular filtration rate (eGFR) were measured 90 patients with cirrhosis hospitalized a single institution between May 2011 January 2012, 30 healthy controls. mAlb, Cr higher compared controls (P<0.05). Urinary significantly...
Objective To investigate hepatocyte growth factor (HGF) levels in the tissue and serum of patients with chronic hepatitis, cirrhosis or hepatocellular carcinoma (HCC), analyze clinical significances HGF for HCC. Method Surgical specimens from 97 were collected during Dec.2003 to Aug.2008 Third Central Hospital.The prospectively enrolled categorized into four groups:normal subjects (n=11), hepatitis B C (n=6), (n=20) HCC (n= 60) including well-differentiated 21), moderately...