A5100341425- Palliative Care and End-of-Life Issues
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Hematopoietic Stem Cell Transplantation
- Antibiotic Resistance in Bacteria
- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- Bacterial Genetics and Biotechnology
- Economic and Financial Impacts of Cancer
- Diverse Approaches in Healthcare and Education Studies
- Mosquito-borne diseases and control
- Studies on Chitinases and Chitosanases
- Insect symbiosis and bacterial influences
- Childhood Cancer Survivors' Quality of Life
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Viral Infections and Vectors
- Physical Activity and Health
- Nutrition and Health in Aging
- Enzyme Structure and Function
- Virus-based gene therapy research
- Physiological and biochemical adaptations
- Vector-borne infectious diseases
- Clinical practice guidelines implementation
Shenzhen MSU-BIT University
2023
University of Pennsylvania
2022-2023
Shanghai University of Medicine and Health Sciences
2021
Huazhong University of Science and Technology
2020
Tongji Hospital
2020
Hubei Provincial Center for Disease Control and Prevention
2020
Queen's University
2020
Dana-Farber Cancer Institute
2014-2018
Tianjin Normal University
2013-2014
Serious illness conversations (SICs) between oncology clinicians and patients are associated with improved quality of life may reduce aggressive end-of-life care. However, most cancer die without a documented SIC.To test the impact behavioral nudges to prompt SICs on SIC rate outcomes among at high risk death within 180 days (high-risk patients) as identified by machine learning algorithm.This prespecified 40-week analysis stepped-wedge randomized clinical trial conducted June 17, 2019,...
Background White spot syndrome virus (WSSV) is a causative pathogen found in most shrimp farming areas of the world and causes large economic losses to aquaculture. The mechanism underlying molecular pathogenesis highly virulent WSSV remains unknown. To better understand virus-host interactions at level, transcriptome profiles hemocytes unchallenged WSSV-challenged (Litopenaeus vannamei) were compared using short-read deep sequencing method (Illumina). Results RNA-seq analysis generated more...
To understand the regulation mechanism of eyestalk ablation on activities hepatopancreas, Illumina RNA-Seq and digital gene expression (DGE) analyses were performed to investigate transcriptome eyestalk, Y-organ, hepatopancreas E. sinensis identify genes associated with metabolism that are differentially expressed under conditions.A total 58,582 unigenes constructed from 157,168 contigs SOAPdenovo. A BlastX search against NCBI Nr database identified 21,678 an E-value higher than 10⁻⁵. Using...
3 Background: Oncologists face challenges associated with increasing cost and medical complexity. The Dana-Farber Cancer Institute (DFCI) has created a customized clinical pathways program that seeks to prospectively support guide decision-making across our network. It also allows the track learn from decisions made. We have analyzed outcomes data before after implementation of Pathways in thoracic oncology program. Methods: Our lung cancer group pathway for treatment non-small cell (NSCLC)....
We examined the association between obesity and physical performance under different metabolic status.The sample included 1395 Chinese community-dwelling participants (mean age, 71.88 ± 5.87 years; 40.9% men). Being metabolically healthy was defined as having presence of < 3 5 components syndrome (MetS); a BMI > 28 kg/m2. Participants were divided into four groups based on (non-obese/obese) health (healthy/unhealthy). Physical measured by grip strength, 4-m walking speed, timed up go test...
The main approach to preventing tick-borne encephalitis (TBE) is vaccination. Formaldehyde-inactivated TBE vaccines have a proven record of safety and efficiency but never been characterized structurally with atomic resolution. We report cryoelectron microscopy (cryo-EM) structure the formaldehyde-inactivated virus (TBEV) Sofjin-Chumakov strain representing Far-Eastern subtype. A 3.8 Å resolution reconstruction reveals structural integrity envelope E proteins, specifically protein...
118 Background: Providing safe and nurturing end-of-life (EOL) care to cancer patients is a challenge in any setting, but particularly so the intensive unit (ICU). In unique collaboration between comprehensive center payer, we sought identify who died ICU conducted chart review-based qualitative analysis better understand their location of death. Methods: We completed an exploratory, based on cohort 264 active Dana-Farber Cancer Institute (DFCI) during 2012 had claims data from Blue Cross...
Chinese shrimp(Fenneropenaeus chinensis)is distributed mainly along inshore areas,and is one of the most important farmed shrimp in China.The studies on innate immune responses shrimps,especially defense against main crustacean pathogens,will provide more knowledge immunity to prevent infectious diseases.Invertebrates do not possess an adaptive system based highly specific antibodies and antigen receptors.They must rely efficient defenses capable protecting them invading microorganisms.The...
106 Background: Addressing utilization near the end of life (EOL) for cancer patients is critical to enhance value care. Cancer EOL measures have been widely endorsed, including by National Quality Forum (chemotherapy in last 14 days; ICU 30 not admitted hospice; hospice < 3 days). However, efforts use these assess hospital quality and constrained, part because currently endorsed specifications do provide a claims-based approach cohort identification, include attribution methodology....
Although prevalent in the determination of protein structures; crystallography always has bottleneck obtaining high-quality crystals for characterizing a wide range proteins; especially large complexes. Stable fragments or domains proteins are more readily to crystallize; which prompts use situ proteolysis remove flexible unstable structures improving crystallization and crystal quality. In this work; we investigated effects by chymotrypsin on XcpVWX complex from Type II secretion system...
Streptomyces clavuligerus produces a number of β-lactam compounds, including clavulanic acid. Here, we describe an efficient procedure for creating acid high producing S. clavuligerus mutant by using traditional UV light treatment method and PCR-targeting system. After inducing S. clavuligerus B71 with light S. clavuligerus B71-14 was selected its 1.91-fold production to the original strain. Then applied polymerase chain reaction (PCR)-targeting system mutate the lat gene of S....
Three-player basketball; Secondary school; Value analysis
109 Background: Early serious illness conversations (SICs) between oncology clinicians and patients are associated with improved mood, quality of life, end-of-life (EOL) care. Yet, most cancer die without a documented SIC. We report on pre-specified 40-week SIC EOL outcomes from stepped-wedge randomized clinical trial (NCT03984773) testing the impact clinician-directed behavioral nudges to prompt SICs among at high risk mortality based machine learning algorithm. Methods: Our sample...