A5101764179- HIV/AIDS Research and Interventions
- Chemical synthesis and alkaloids
- Breast Cancer Treatment Studies
- Advanced Neural Network Applications
- HIV, Drug Use, Sexual Risk
- Catalytic C–H Functionalization Methods
- Alkaloids: synthesis and pharmacology
- HIV Research and Treatment
- Statistical Methods in Clinical Trials
- Anomaly Detection Techniques and Applications
- Adversarial Robustness in Machine Learning
- Synthetic Organic Chemistry Methods
- Traditional and Medicinal Uses of Annonaceae
- Ferroptosis and cancer prognosis
- Statistical Methods and Inference
- Microbial Natural Products and Biosynthesis
- Adolescent Sexual and Reproductive Health
- Asymmetric Synthesis and Catalysis
- HER2/EGFR in Cancer Research
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organoboron and organosilicon chemistry
- Epigenetics and DNA Methylation
- Synthesis of β-Lactam Compounds
Shandong University
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tsinghua University
2018-2024
Shandong Women’s University
2024
Beijing Normal University - Hong Kong Baptist University United International College
2024
Henan Cancer Hospital
2018-2023
Zhengzhou University
2015-2023
Chongqing University
2023
To develop and validate an HIV risk assessment tool to predict acquisition among African women.Data were analyzed from 3 randomized trials of biomedical prevention interventions women (VOICE, HPTN 035, FEM-PrEP).We implemented standard methods for the development clinical prediction rules generate a risk-scoring over course 1 year. Performance score was assessed through internal external validations.The final resulting multivariable modeling included age, married/living with partner, partner...
Despite that the segment anything model (SAM) achieved impressive results on general-purpose semantic segmentation with strong generalization ability daily images, its demonstrated performance medical image is less precise and not stable, especially when dealing tumor tasks involve objects of small sizes, irregular shapes, low contrast. Notably, original SAM architecture designed for 2D natural therefore would be able to extract 3D spatial information from volumetric data effectively. In...
Systemic inflammatory cell ratio, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), and lymphocyte-monocyte (LMR) are used as prognostic indicators for several types of tumors. The purpose this study was to evaluate the predictive value markers pathological response prognosis in breast cancer patients receiving neoadjuvant chemotherapy (NAC).In study, we collected data 203 who underwent surgery after standard therapy. effects NLR, PLR, LMR on disease-free survival (DFS) with were...
The collective synthesis of skeletally diverse Stemona alkaloids featuring tailored dyotropic rearrangements β-lactones as key elements is described. Specifically, three typical 5/7/5 tricyclic skeletons associated with stemoamide, tuberostemospiroline and parvistemonine were first accessed through chemoselective involving alkyl, hydrogen, aryl migration, respectively. By the rational manipulation substrate structures reaction conditions, these proceeded excellent efficiency, good...
An unprecedented chiral bisphosphine-catalyzed asymmetric Staudinger/aza-Wittig reaction of 2,2-disubstituted cyclohexane-1,3-diones is reported, enabling the facile access a broad range cis-3a-arylhydroindoles in high yields with excellent enantioselectivities. The key to success this work relies on first application bisphosphine DuanPhos reaction. effective reductive system has been established address challenging PV═O/PIII redox cycle associated catalyst. In addition, comprehensive...
Recently, chloroquine (CQ) has been widely used to improve the efficacy of different chemotherapy drugs treat tumors. However, effects single treatment CQ on liver cancer have not investigated. In present study, we examined growth and viability cells in vitro vivo, revealed that triggered G0/G1 cell cycle arrest, induced DNA damage apoptosis a dose- time-dependent manner cells. Moreover, administration tumor-bearing mice suppressed tumor an orthotopic xenograft model cancer. These findings...
Out-of-Distribution (OOD) detection is critical for the reliable operation of open-world intelligent systems. Despite emergence an increasing number OOD methods, evaluation inconsistencies present challenges tracking progress in this field. OpenOOD v1 initiated unification but faced limitations scalability and usability. In response, paper presents v1.5, a significant improvement from its predecessor that ensures accurate, standardized, user-friendly methodologies. Notably, v1.5 extends...
In brief Abnormal glucose metabolism may be involved in the pathogenesis of endometriosis. The present study identifies that highly expressed H19 leads to increased aerobic glycolysis and histone lactylation levels Abstract Previous studies from our group others have shown IncRNA expression both eutopic endometrium ectopic endometriosis tissue during this study, we use immunofluorescence, immunohistochemistry, protein quantification determine are tissues. human endometrial stromal cells,...
We present Matrix3D, a unified model that performs several photogrammetry subtasks, including pose estimation, depth prediction, and novel view synthesis using just the same model. Matrix3D utilizes multi-modal diffusion transformer (DiT) to integrate transformations across modalities, such as images, camera parameters, maps. The key Matrix3D's large-scale training lies in incorporation of mask learning strategy. This enables full-modality even with partially complete data, bi-modality data...
We present Step-Video-T2V, a state-of-the-art text-to-video pre-trained model with 30B parameters and the ability to generate videos up 204 frames in length. A deep compression Variational Autoencoder, Video-VAE, is designed for video generation tasks, achieving 16x16 spatial 8x temporal ratios, while maintaining exceptional reconstruction quality. User prompts are encoded using two bilingual text encoders handle both English Chinese. DiT 3D full attention trained Flow Matching employed...
Patients with human epidermal growth factor receptor 2 (HER2)-low advanced breast cancer can benefit from trastuzumab deruxtecan. Given the unclear prognostic characteristics of HER2-low cancer, we investigated expression primary tumor to residual disease after neoadjuvant chemotherapy (NACT).The data HER2-negative patients receiving NACT at our center were collected. Pathological complete response (pCR) rate compared between HER2-0 and patients. The evolution HER2 its impact on disease-free...
The reaction mechanism of Brønsted acid-catalyzed silane-dependent P═O reduction has been elucidated through combined computational and experimental methods. Due to its remarkable chemo- stereoselective nature, the acid/silane system widely employed in organophosphine-catalyzed transformations involving P(V)/P(III) redox cycle. However, full mechanistic profile this type yet be clearly established date. Supported by both DFT studies, our research reveals that likely proceeds mechanisms other...
GBV-C infection is associated with prolonged survival and reduced T cell activation in HIV-infected subjects not receiving combination antiretroviral therapy (cART). The relationship between was examined. on cART non-detectable HIV viral load (VL) or naïve were studied. VL determined. Cell surface markers of (CD38+/HLA-DR+), proliferation (Ki-67+), entry co-receptor expression (CCR5+ CXCR4+) total CD4+ CD8+ cells, naïve, central memory (CM), effector (EM), subpopulations measured by flow...
Increasing evidence suggests that deubiquitinase USP7 participates in tumor progression by various mechanisms and serves as a potential therapeutic target. However, its expression role esophageal cancer remains elusive; the anti‐cancer effect targeting still needs to be investigated. Here, we reported was overexpressed squamous cell carcinoma (ESCC) tissues compared with adjacent tissues, implying an attractive anticancer target of ESCC. Pharmaceutical or genetic inactivation inhibited cells...
Recent reports showed that haematological and neurological expressed 1-like (HN1L) gene participated in tumorigenesis tumour invasion. However, the expression role of HN1L breast cancer remain to be investigated. Here, bioinformatics, western blot immunohistochemistry were used detect cancer. Wound healing, transwell assay, immunofluorescence assay mass spectrum explore mechanism on migration invasion cancer, which was confirmed vivo using a nude mice model. Results significantly...
Objective: Interleukin-2 (IL-2) is a cytokine with multiple effects on lymphocytes including induction of CD4+ T-cell proliferation. IL-2 administration has been shown to increase CD4 cell counts in HIV-infected people receiving antiretroviral therapy. GB virus C (GBV-C) an apparently nonpathogenic flavivirus that replicates T cells and inhibits HIV replication vitro by mechanisms downregulation entry coreceptors (CCR5 CXCR4) chemokines (RANTES, MIP-1α, MIP-1 β, SDF-1). GBV-C significantly...
Young women aged 15-24 years are disproportionately affected by the HIV epidemic. Two phase III trials of a vaginal ring containing 25-mg dapivirine demonstrated HIV-1 risk reduction in adult older than 21 but not those 18-21 years. Lack protection was correlated with low adherence.In this phase-IIa, randomized, double-blind, placebo-controlled, US, multicenter trial sexually active females, 15-17 years, participants were randomized 3:1 to or placebo be inserted monthly for 6 months...
Based on the association between hormone receptor and status of human epidermal growth factor 2 (HER2)-low, we investigated clinicopathological prognostic characteristics HER2-low in early-stage triple-negative breast cancer (TNBC).
The N-heterocyclic carbene (NHC)-catalyzed enantioselective Petasis-like alkenylation of o-hydroxycinnamaldehydes or hydroxyl-tethered α,β-unsaturated aldehydes with styryl, dienyl, trienyl boronic acids is disclosed. This method involves the addition π-system-containing to NHC-bounded acyl azoliums and allows access divergent assembly β-alkenyl substituted dihydrocoumarin γ- δ-lactones. DFT calculations suggest that an unprecedented zwitterionic intermediate 1,4- 1,5- migration alkenyl...
We report a carbene-catalyzed [4 + 2] annulation of activated esters and β-borate enones, providing an efficient method to build enantioenriched organoborones with two consecutive stereogenic centers. It is worth noting that this protocol represents new organocatalytic manner generate chiral β-C–B bonds. Moreover, it also greatly enriches the structural diversity organoboron compounds.
Postmenopausal women have unique sociobiological human immunodeficiency virus (HIV) risks. We evaluated the safety, pharmacokinetics, and acceptability of a microbicide dapivirine (DPV) vaginal ring (VR) versus placebo in postmenopausal women.We enrolled 96 HIV-negative US phase 2a double-blind, randomized (3:1) trial monthly VRs containing 25 mg DPV or used continuously for 12 weeks. assessed safety by adverse events (AEs). concentrations were quantified plasma fluid. Steady-state analyzed...
Vaginal rings (VRs) are a promising approach for sustained delivery of antiretroviral (ARV) medication to prevent human immunodeficiency virus (HIV) infection in women. Combination ARV VRs could increase efficacy.MTN-028, phase 1 trial 19 HIV-uninfected women, evaluated 2 containing vicriviroc (VCV) and MK-2048. Participants were randomized 2:1 low-dose (VCV, 91 mg; MK-2048, 10 mg) or original-dose 182 30 ring used 28 days. Safety was assessed by documenting adverse events (AEs). Drug...