Does platelet-derived transforming growth factor-β1 (TGF-β1) have any role in the reduced cytotoxicity of natural killer (NK) cells women with endometriosis? Platelet-derived TGF-β1 suppresses expression NK Group 2, Member D (NKG2D) on cells, resulting endometriosis, but neutralization reverses reduction. are cytotoxic lymphocytes that play an important peritoneal immune surveillance, and their function is known to be impaired endometriosis. There increased platelet aggregation endometriotic...

Do platelets have any role in the reduced cytotoxicity of natural killer (NK) cells endometriosis?Platelets impair NK cell reactivity and function endometriosis through multiple mechanisms.Platelets play an important development endometriosis, platelet-derived transforming growth factor-β1 (TGF-β1) suppresses expression Group 2, Member D (NKG2D) on cells, resulting women with endometriosis.Experiments mice induced which either platelets, or both were depleted controls (none depleted). In...

In brief Abnormal glucose metabolism may be involved in the pathogenesis of endometriosis. The present study identifies that highly expressed H19 leads to increased aerobic glycolysis and histone lactylation levels Abstract Previous studies from our group others have shown IncRNA expression both eutopic endometrium ectopic endometriosis tissue during this study, we use immunofluorescence, immunohistochemistry, protein quantification determine are tissues. human endometrial stromal cells,...

Abstract Gonadotropin-releasing hormone agonist (GnRH-a) is generally added to the improve pregnancy outcomes of replacement therapy cycles among patients with adenomyosis. We aimed investigate whether adding GnRH-a can result in better outcomes. This retrospective analysis included 341 adenomyosis who underwent frozen embryo transfer (FET) after vitro fertilization (IVF). The control group was treated only prepare endometrium, and study before administration adjust menstruation cycle. Based...

The cumulative live birth rate (CLBR) can better reflect the overall treatment effect by successive treatments, and continuous rather than categorical variables as exposure increase statistical power in detecting potential correlation. Therefore, dose–response relationships might find an optimal dose for CLBR, offering evidence-based references clinicians. To determine of factors ranges assisted reproductive technology (ART) associated with a higher this study retrospectively analyzed 16,583...

The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits surgical treatment remain uncertain. This study aimed to investigate effect quality from a morphological perspective further explore whether surgery could contribute improving competence. A total 664 IVF cycles with (538 underwent surgeries) 3133 control group were included. propensity score matching was used balance baseline differences between groups. There lower MII rate (85.0% versus...

Abstract Atosiban was commonly added to improve pregnancy outcomes of patients with repeated embryo implantation failure (RIF). In this study, we aimed investigate the effect atosiban before transferring frozen-thawed RIF patients. This retrospective study conducted in Hospital for Reproductive Medicine affiliated Shandong University from August 2017 June 2021. A total 1774 women a history undergoing frozen transfer (FET) were included study. All participants classified into or control...

Purpose: The aim of this study was to investigate the effect human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer women with endometriosis (EM). Methods: We performed a retrospective, database-search, cohort and included data on EM patients who underwent (FET) between January 1, 2009 August 31, 2018. According protocols FET cycle, were divided into two groups: control group ( n = 296) hCG 355). Clinical pregnancy rate, live birth early...

Immune tolerance at the fetomaternal interface must be established during processes of implantation and pregnancy. Monoclonal nonspecific suppressor factor beta (MNSF β ) is a secreted protein that possesses antigen-nonspecific immune-suppressive function. It was previously reported intrauterine immunoneutralization MNSF significantly inhibited embryo in mice. In present study, expression up- or downregulated by overexpression RNA interference, respectively, HCC-94 cells culture supernatants...

Apoptosis of ovarian granulosa cells (GCs) affects the development and maturation oocyte in Polycystic ovary syndrome (PCOS).The objective our study was to examine impact S100A11 on individuals with polycystic syndrome. We found that level higher PCOS patients tissue mouse models. overexpression experiments demonstrated a decrease cell proliferation, upregulating apoptosis blocking cycle. Immunofluorescence staining showed proteins were mainly located nucleus. Integrating RNA-seq ChIP-seq,...

Low-dose aspirin is widely used during frozen-embryo transfer (FET) cycles. Its anti-platelet property makes it a potentially useful drug for the prevention of hypertension disorders pregnancy (HDP). However, existing evidence about effect short-term administration on outcomes not clear. In our study, we retrospectively investigated women who had their first or second FET cycles at Reproductive Hospital Affiliated with Shandong University from April 2017 to December 2020. A total 4454...

To investigate the reproductive outcomes by comparing two kinds of antibiotic schemes for chronic endometritis (CE) in infertile women's fresh embryo transfer (FET) cycles and identify subgroups patients with CE who need long-term antibiotics treatment.A retrospective cohort study.University-based medical center.A total 492 women CD138-positive plasmacytes per 10 high-power fields (CD138+/10HPF).Hysteroscopy was performed endometrial biopsy samples were collected proliferative phase....

Abstract Purpose To investigate the effect of hCG in hormone replacement regime for frozen thawed embryo transfer women with endometriosis. Methods We performed a retrospective, database-searched cohort study. The data endometriosis patients who underwent between 1/1/2009-31/8/2018 were collected. According to protocols cycle, these divided into two groups: Control group(n=305), and group(n=362). And clinical pregnancy rate, live birth early abortion late rate ectopic compared groups....

Abstract Background: Endometriosis is a chronic disease associated with disorder of the oxidative balance and inflammation. Although endometriosis benign disease, it has characteristics properties similar to malignant cancer. Methods: The present study aim investigate role glutathione S-transferase Mu class 4 (GSTM4), tested if 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) could regulate GSTM4 expression affect cell proliferation, migration, invasion apoptosis in endometriosis....

Abstract Gonadotropin-releasing hormone agonist(GnRH-a) is generally added to improve pregnancy outcomes of adenomyosis based replacement therapy cycle. Our objective in this study investigate whether adding GnRH-a can obtain better outcomes. In retrospective analysis, a total 341 patients with complicated vitro fertilization-embryo transfer(IVF-ET) the frozen embryo transfer (FET). The control group was only treated by cycles prepare emdometrium, and before using adjust menstruation period....

Aims: The primary aim of the current study was to elucidate function stimulator interferon genes (STING) in eutopic endometrium women with endometriosis. Materials and Methods: STING expression signaling pathways were verified by western blot analysis immunohistochemistry after si-STING treatment. Cell proliferation invasion migration assessed using 5-ethynyl-2'-deoxyuridine transwell assays, respectively. Results: Within endometriosis tissues, primarily expressed stroma glandular epithelium...