A5063965332- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Calcium signaling and nucleotide metabolism
- Sphingolipid Metabolism and Signaling
- Adipose Tissue and Metabolism
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- Oral microbiology and periodontitis research
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds and Antitumor Agents
- Fibroblast Growth Factor Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatitis C virus research
- PARP inhibition in cancer therapy
Nanchang University
2016-2025
Nankai University
2012-2016
Abstract Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage activation are not completely understood. Members of tripartite motif (TRIM) family have recently emerged as players innate immunity antivirus. Here, we systematically analyzed mRNA expressions representative TRIM molecules human THP1-derived activated by different toll-like receptor (TLR) ligands. Twenty-nine...
Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon-like peptide-1 (GLP-1). However, the extremely short half-life of GLP-1 due degradation by ubiquitous proteolytic enzyme limits its clinical application. In this study, we engineered recombinant integrant probiotic strain
Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates connection between HHcy periodontitis; however, the underlying processes remain unknown. Herein, we explored mechanisms by which exacerbates osteoclast formation. In an...
Shikonin, a naphthoquinone derivative isolated from the root of Lithospermum erythrorhizon, exhibits broad-spectrum antitumor activity via different molecular mechanisms. In this study, we investigated effect shikonin on mitochondrial dysfunction in hepatocellular carcinoma (HCC). Our results showed that inhibited proliferation, migration, and invasiveness HCCLM3 cells, promoted cell apoptosis dose-dependent manner. More importantly, affected function by disrupting membrane potential...
Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, antioxidant effects and antibacterial on foodborne pathogens of fermentation supernatant were evaluated in vitro. Our results indicated that fermented by Lactobacillus plantarum HM218749.1 had very strong scavenging capacities DPPH (86%),<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mi...
Background and AimsOsteopontin (OPN) is reported to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, function OPN in NAFLD still inconclusive. Therefore, our aim this study was evaluate role clarify involved mechanisms.
Abdominal aortic aneurysm (AAA) is a serious vascular disease which associated with remodeling. CD38 main NAD+-consuming enzyme in mammals, and our previous results showed that plays the important roles many cardiovascular diseases. However, role of AAA has not been explored. Here, we report smooth-muscle-cell-specific deletion (CD38SKO) significantly reduced morbidity AngII-induced CD38SKOApoe−/− mice, was accompanied increases diameter, medial thickness, collagen deposition, elastin...
LXR (liver X receptor) is a ligand-activated transcription factor and plays an important role in regulation of lipid homoeostasis inflammation. Several studies indicate that inhibits IFN-γ (interferon γ)-induced biological responses; however, the influence on expression has not been fully elucidated. In present study, we investigated effects activation at different levels. At molecular level, surprisingly observed ligand (T0901317) induced macrophage T-cell protein which was associated with...
CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in variety of cell types. The functions are involved numerous biological processes including immune responses. Here, we showed the downregulations both TLR2 mRNA protein macrophages from CD38-/- mice knockdown RAW264.7 cells. Several NF-κB-binding motifs promoter region gene were by bioinformatics analysis confirmed luciferase activity assay with different truncated promoters. deficiency...
The development of nonalcoholic fatty liver disease (NAFLD) has been reported to be caused by sphingolipid family inducing insulin resistance, mitochondrial dysfunction, and inflammation, which can regulated multiple metabolic pathways. This study aimed explore the molecular mechanism crucial metabolism related genes (SMRGs) in NAFLD. Firstly, datasets (GSE48452, GSE126848, GSE63067) from Gene Expression Omnibus database (SMGs) previous research were collected for this study. differentially...
Activated macrophages serve a key role in various inflammatory diseases, such as atherosclerosis and septic shock. Tripartite motif-containing protein 65 (TRIM65) has been previously reported to participate tumor progression lung inflammation. However, the molecular mechanisms that controls its expression under conditions consequences activated remain poorly understood. The present study first collected tissues of C57BL/6J mice, smooth muscle cells, endothelial cells determine distribution...
Macrophage adipocyte fatty acid-binding protein (FABP4) plays an important role in foam cell formation and development of atherosclerosis. Tamoxifen inhibits this disease process. In the present study, we determined whether anti-atherogenic property tamoxifen was related to its inhibition macrophage FABP4 expression. We initially observed that inhibited macrophage/foam formation, but attenuated when expression selectively by siRNA. then 4-hydroxytamoxifen primary macrophages isolated from...