A5013970397- Mental Health Research Topics
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- RNA Interference and Gene Delivery
- Seaweed-derived Bioactive Compounds
- Immune Response and Inflammation
- Mental Health Treatment and Access
- Epilepsy research and treatment
- Extracellular vesicles in disease
- Tuberculosis Research and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Beetle Biology and Toxicology Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Digital Mental Health Interventions
- Computational Drug Discovery Methods
- Congenital heart defects research
- Cholinesterase and Neurodegenerative Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- COVID-19 and Mental Health
- Antimicrobial Peptides and Activities
- Metabolism and Genetic Disorders
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- HIV/AIDS drug development and treatment
Shanghai Children's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Panzhihua Central Hospital
2022-2024
Kunming Medical University
2022-2024
University of South China
2024
Beijing Anding Hospital
2022-2023
Capital Medical University
2022-2023
Shanghai Children's Medical Center
2022
Newborn screening (NBS) aims to detect congenital anomalies, and next-generation sequencing (NGS) has shown promise in this aspect. However, the NBS strategy for monogenic inherited diseases China remains insufficient. We developed a NeoEXOME panel comprising 601 genes that are relevant Chinese population found through extensive research on available databases. An interpretation system grade results into positive (high-risk, moderate-risk, low-risk genotypes), negative, carrier according...
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator inflammation and infection, but its role during M . infection remains unknown. Here, we reveal that endogenous pro-inflammatory metabolite infection. Irg1 knockout (KO) mice had lower levels bacterial burden, lactate dehydrogenase (LDH), cytokines compared with wild-type...
Malignant tumors have become the main cause of harm to human life and health. Development for new antitumor drugs exploration drug carriers are becoming concerned focus. In this study, we exploited our experiments explore effect NCTD-NLC on liver cancer cells: HepG2 cells cultured in vitro were given with administration; then, estimation cellular proliferation apoptosis was accomplished through MTT flow cytometry. Six hours after administration, performed High Performance Liquid...
Amygdala plays an important role in the neurobiological basis of panic disorder (PD), and amygdala contains different subregions, which may play roles PD. The aim present study was to examine whether there are common or distinct patterns functional connectivity subregions PD using resting-state magnetic resonance imaging explore relationship between abnormal spontaneous regions interest (ROIs) clinical symptoms patients.Fifty-three drug-naïve, non-comorbid patients 70 healthy controls (HCs)...
Calcium channel blocker (CCB) is known to possess antibacterial effects. We aimed apply network pharmacology (docking and protein-protein interaction [PPI] analyses) predict the potential targets mechanisms of CCB against Pseudomonas aeruginosa (PA) as well verify effect these drugs. The chemical structures three CCBs were obtained through Drug Bank platform. proteins, efflux pump proteins ion bacteria derived from literature. These collected PDB Uniprot binding mode docking complexes was...
Oxidative stress is associated with the development of many diseases, such as chronic inflammation, cardiovascular disease and cancer. Antioxidants can scavenge free radicals in body, reduce production reactive oxygen species (ROS) effectively prevent oxidative stress. Polysaccharide a antioxidants that widely found natural resources, which kind high molecular polymer antioxidant activity. It play role prevention through various mechanisms. In this paper, different types polysaccharides were...
The possible mechanism of Xiyanping injection treatment COVID-19 is discussed through the network pharmacology.Obtaining chemical structure patent application and obtaining control compounds I, II, III, IV, V, Yanhuning (VI, VII), Chuanhuning (VIII, IX), 10 were analyzed by D3Targets-2019-nCoV. human anti-COVID-19 gene in DisGeNET was intersected with CTD Andrographolide target then combined D3Targets-2019-nCoV, resulting 93 genes, using Venny 2.1 platform. PPI constructed String platform...
With the global aging, geriatric emotional disorders have received more and attention. Psychotherapy is an effective approach for alleviating symptoms associated with disorder, but number of experienced therapists low. Studies should be conducted to explore a low-cost efficient treatment method. Previous findings indicate that transdiagnostic cognitive behavior therapy disorders. Group appropriate elderly as they are characterized by high levels loneliness. In this study, we compared...
Background: The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and clinical significance CYP2C9 gene polymorphisms personalized dosing using therapeutic drug monitoring pharmacogenetic testing. Methods: medical records children who underwent at our institution between July 2022 2023 met inclusion criteria were reviewed. Statistical analysis performed determine whether age, sex, blood ammonia, liver...
Exosomes are extracellular vesicles naturally released from cells. different sources play roles in cellular component exchange, signal transduction, and pathological development. have distinct biological characteristics such as low immunogenicity, easy uptake by cells, crossing the blood-brain barrier, natural targeting, modification. Many studies show that exosomes drug carriers a great application prospect cancer therapy. In this review, we review biogenesis, origin, of exosomes, exosome...
Newborn screening (NBS) is an effective way for 3-step prevention of birth defects. The suitable technology and rational NBS diseases are critical each country area. High-throughput sequencing has shown high application potential in NBS. However, lack strategy monogenic inherited China. In this study, we systematically evaluated the efficiency different approaches NBS, a gene-disease association list (NeoExome panel) Chinese population with 601 genes was designed based on top rare disease...
Background: The quality indicators (QIs) were issued to monitor the comprehensive management system (CQMS) of newborn screening (NBS) in China 2014. However, few studies on evaluation CQMS are available China. This study aims evaluate by QIs NBS at national level between 2015 and 2020.Methods: Data sourced from National Center for Clinical Laboratories (NCCL) 2020, 16 monitoring entire process used assess NBS. We firstly estimated rates laboratory types (NBSCs vs. non-NBSCs), regions...