A5108061181- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Beetle Biology and Toxicology Studies
- Natural Compounds in Disease Treatment
- Bone Metabolism and Diseases
- Medicinal Plants and Bioactive Compounds
- Glycosylation and Glycoproteins Research
- Cooperative Communication and Network Coding
- Orthopedic Infections and Treatments
- Andrographolide Research and Applications
- Pharmacy and Medical Practices
- Software-Defined Networks and 5G
- Pancreatic and Hepatic Oncology Research
- Antimicrobial Resistance in Staphylococcus
- Galectins and Cancer Biology
- Wireless Networks and Protocols
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and bioactivity of alkaloids
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Surgical site infection prevention
- Bone and Dental Protein Studies
- RNA Interference and Gene Delivery
Panzhihua Central Hospital
2011-2025
Fujian Provincial Hospital
2021-2023
Fujian Medical University
2021-2022
Objective Current guidelines recommend vancomycin concentrations of 10–20 μg/mL for most infections, with higher levels (15–20 μg/mL) suggested severe cases. However, evidence supporting these recommendations in periprosthetic joint infection (PJI) is limited. This study aims to evaluate the impact different concentration ranges (10–15 vs. 15–20 on safety and effectiveness PJI population. Methods retrospective included 37 patients Therapeutic Drug Monitoring due infection. Patients were...
Development of a panel serum autoantibody against Neuron specific gene family member 1 (NSG1) with traditional tumor biomarkers esophageal squamous cell carcinoma (ESCC) to further improve the diagnostic efficiency for ESCC patients. Immunohistochemistry (IHC) staining was used detect expression NSG1 protein in 40 pairs tissues and matched paracancerous tissues. Serum anti-NSG1 levels 203 patients early ESCC, 103 advanced 135 benign lesion (EBL), 155 healthy controls (HCs) were detected by...
Background Considering the absence of apparent symptoms at early stage, most patients with lung adenocarcinoma (LUAD) present an advanced leading to a dismal 5-year survival rate <20%. Thus, finding perspective non-invasive biomarkers for LUAD is very essential. Methods We developed fucose-captured strategy based on lentil lectin-magnetic beads isolate fucosylated exosomes from serum. Then, prospective study was conducted define diagnostic value serum exosomal miRNAs LUAD. A total 310...
Calcium channel blocker (CCB) is known to possess antibacterial effects. We aimed apply network pharmacology (docking and protein-protein interaction [PPI] analyses) predict the potential targets mechanisms of CCB against Pseudomonas aeruginosa (PA) as well verify effect these drugs. The chemical structures three CCBs were obtained through Drug Bank platform. proteins, efflux pump proteins ion bacteria derived from literature. These collected PDB Uniprot binding mode docking complexes was...
The possible mechanism of Xiyanping injection treatment COVID-19 is discussed through the network pharmacology.Obtaining chemical structure patent application and obtaining control compounds I, II, III, IV, V, Yanhuning (VI, VII), Chuanhuning (VIII, IX), 10 were analyzed by D3Targets-2019-nCoV. human anti-COVID-19 gene in DisGeNET was intersected with CTD Andrographolide target then combined D3Targets-2019-nCoV, resulting 93 genes, using Venny 2.1 platform. PPI constructed String platform...
Background: The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and clinical significance CYP2C9 gene polymorphisms personalized dosing using therapeutic drug monitoring pharmacogenetic testing. Methods: medical records children who underwent at our institution between July 2022 2023 met inclusion criteria were reviewed. Statistical analysis performed determine whether age, sex, blood ammonia, liver...
Exosomes are extracellular vesicles naturally released from cells. different sources play roles in cellular component exchange, signal transduction, and pathological development. have distinct biological characteristics such as low immunogenicity, easy uptake by cells, crossing the blood-brain barrier, natural targeting, modification. Many studies show that exosomes drug carriers a great application prospect cancer therapy. In this review, we review biogenesis, origin, of exosomes, exosome...
<title>Abstract</title> Objective Type 2 Diabetes Mellitus (T2D) and Osteoarthritis (OA) are prevalent diseases significantly impacting patients' quality of life. Increasing evidence suggests a correlation between T2D OA, yet their molecular mechanisms remain elusive. Our study aims to investigate shared biomarkers potential underlying these diseases. Methods Gene expression profiles for OA were sourced from the Expression Omnibus (GEO) database.We employed bioinformatics identify...
Abstract Demethylcantharidin (DEM) is a widely used antitumor drug; however, its poor tumor targeting and serious organotoxicity limit application. The aim of this study was to develop new drug delivery system for efficient DEM. Nanoemulsion based lipid nanoparticles containing demethylcantharidin (DNLNs) were prepared by loading nanoemulsions into nanoparticles. cells proliferation, apoptosis, cycle, uptake investigated Cell counting kit‐8 (CCK‐8), flow cytometry, in situ fluorescence...
Novel antitumor drugs and nano-delivery systems for treating liver cancer are becoming a research hotspot, given that the incidence mortality rates of high. Herein, nanoemulsion hybrid lipid carriers containing norcantharidin (Nor) (NNHLCs) were first prepared by loading water-in-oil nanoemulsions into solid lipids using nanoemulsion-thin film ultrasonic dispersion method. The in vitro vivo kinetic features determined situ unidirectional perfusion plasma concentration-time curve method,...
Abstract Cysteine Protease Inhibitor 1 (CST1), a cystatin superfamily protein with the effect on inhibition of cysteine protease activity , is reported to be involved in development many malignancies. Mitochondrial oxidative phosphorylation (OXPHOS) also plays an important role regulating cancer cell growth. However, relationship and CST1 OXPHOS esophageal squamous carcinoma (ESCC) remains unknown. In our pilot study, was shown potential promoting ESCC migration invasion by activation...