Li Chen

ORCID: 0000-0003-4074-9481
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Fungal Biology and Applications
  • Microbial Natural Products and Biosynthesis
  • Polysaccharides and Plant Cell Walls
  • Seaweed-derived Bioactive Compounds
  • Cell Adhesion Molecules Research
  • Plant-Microbe Interactions and Immunity
  • Peptidase Inhibition and Analysis
  • Biochemical and Structural Characterization
  • Marine Sponges and Natural Products
  • Inflammatory mediators and NSAID effects
  • Plant biochemistry and biosynthesis
  • Cancer Treatment and Pharmacology
  • Synthetic Organic Chemistry Methods
  • Gut microbiota and health
  • Polysaccharides Composition and Applications
  • Flavonoids in Medical Research
  • Biocrusts and Microbial Ecology
  • Steroid Chemistry and Biochemistry
  • Toxin Mechanisms and Immunotoxins
  • Pharmacological Effects of Natural Compounds
  • Microbial Metabolites in Food Biotechnology
  • S100 Proteins and Annexins
  • Chemical Synthesis and Analysis
  • Phytochemicals and Antioxidant Activities

Jinan University
2023

Wuhan University
2018

Boston University
2018

Fuzhou University
2017

The University of Texas Health Science Center at Houston
2016

Brown Foundation
2014-2016

Shanghai Ocean University
2016

The University of Texas at Austin
2014

Institute of Molecular Medicine
2014

National Engineering Research Center for Information Technology in Agriculture
2011

The aim of this study was to investigate the structural characteristics and in vitro fermentation patterns polysaccharides from Boletus mushrooms. Polysaccharides were solubilized fruit bodies selected mushrooms auripes, B. bicolor, griseus using subcritical water extraction. characterized for their general physicochemical pattern, constituent monosaccharides molecular weight. A simulated model used utilization by gut microbiota consequent modulation microbial communities. Results showed...

10.1039/d3fo01085f article EN Food & Function 2023-01-01

A mutational analysis of the enterocin biosynthesis genes revealed that putative oxygenase and methyltransferase gene products EncM EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation either terminated production caused accumulation four nonrearranged, nonmethylated polyketides. The structure elucidation new wailupemycins E−G is reported.

10.1021/ol0255155 article EN Organic Letters 2002-03-01

Pneumocandins are lipohexapeptides of the echinocandin family that inhibit fungal 1,3-β-glucan synthase. Most pathway steps have been identified previously. However, lipoinitiation reaction has not yet experimentally verified. Herein, we investigate step pneumocandin biosynthesis in Glarea lozoyensis and demonstrate gene product, GLligase, catalyzes this step. Disruption GLHYD, a encoding putative type II thioesterase sitting upstream acyl side chain synthase gene, GLPKS4, revealed GLHYD was...

10.1021/acschembio.6b00604 article EN ACS Chemical Biology 2016-08-05

Two new secalonic acid derivatives, acids H and I (1 2), one known compound, D (3), were isolated from the marine-derived fungus Penicillum oxalicum.The planar structures relative configurations of compounds elucidated by analyses their 1D 2D NMR high-resolution mass spectrometric data.The absolute established comparison experimental calculated electronic circular dichroism spectra.The in vitro cytotoxic activities 1 2 evaluated against selected human cell lines.Cancer is leading causes...

10.3987/com-17-13758 article EN Heterocycles 2017-01-01

Pleurotus eryngii oligosaccharides (PEOs) were prepared by hydrolyzing P. polysaccharides with hydrogen peroxide (H2O2). The antioxidant activities of PEOs evaluated. Results revealed that PEO yields affected reaction time, temperature and H2O2 concentration. These parameters optimized as follows: 2 h; temperature, 85C; concentration, 2%. yield reached 10.58% under the conditions. showed strong reducing power high scavenging against hydroxyl 2,2-diphenyl-β-picrylhydrazyl radicals. Therefore,...

10.1111/jfpp.13007 article EN Journal of Food Processing and Preservation 2016-06-28

Pleurotus nebrodensis were packaged with PVC and PE different thickness (0.03 mm 0.05 mm) at 4°С. Package gas composition, respiration rate relative electrolyte leakage measured during storage 4°С 95%RH for 28 days. The results showed that auto modified atmosphere pattern would be formed 7th day of the storage. concentration in package films was 0.1~5% O 2 6%~10%CO after 7days, then maintaining stable following days test. Compared to 0.03 film, film more effective decreasing pleurotus delay...

10.4028/www.scientific.net/amr.201-203.2615 article EN Advanced materials research 2011-02-01

To study the toxicity-decreasing and synergistic effect of intracellular extracellular polysaccharides from Phellinus igniarius on S180 mice. The PIP PIE were extracted products liquid submerged fermentation P. igniarius. Transplanting mice tumor models established so as to observe changes in inhibiting rate, indexes spleen thymus, body weight, peripheral blood cells IFN-gamma levels when CTX was used alone combination with results indicate that can increase activity immunity, attenuate...

10.4268/cjcmm20120634 article EN China Journal of Chinese Materia Medica 2012-03-15
Coming Soon ...