A5102962486- Laser Applications in Dentistry and Medicine
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ferroptosis and cancer prognosis
- Photoreceptor and optogenetics research
- Biomarkers in Disease Mechanisms
- Fault Detection and Control Systems
- Periodontal Regeneration and Treatments
- Immunotherapy and Immune Responses
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Microfluidic and Capillary Electrophoresis Applications
- Adaptive Control of Nonlinear Systems
- Cancer Immunotherapy and Biomarkers
- Advanced Control Systems Optimization
- 3D Printing in Biomedical Research
- Advanced Sensor and Control Systems
- Historical Studies in Science
- Ear and Head Tumors
- Heme Oxygenase-1 and Carbon Monoxide
- Natural Compounds in Disease Treatment
- Cardiovascular Conditions and Treatments
- Bacterial Genetics and Biotechnology
- Advanced Glycation End Products research
- Adaptive Dynamic Programming Control
First Affiliated Hospital of Kunming Medical University
2021-2025
Kunming Medical University
2015-2025
Beijing Institute of Technology
2006-2024
Shandong University
2021-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Shenyang University of Technology
2023
Weifang Medical University
2023
Chinese University of Hong Kong
2018-2022
Jinzhou Medical University
2020
Existing local drug delivery systems for periodontitis suffer from poor antibacterial effect and unsatisfied periodontal regeneration. In this study, a smart gingipain-responsive hydrogel (PEGPD@SDF-1) was synthesized as an environmentally sensitive carrier on-demand delivery. The PEGPD@SDF-1 polyethylene glycol diacrylate (PEG-DA) based scaffolds, dithiothreitol (DTT), novel designed functional peptide module (FPM) via Michael-type addition reaction, the further loaded with stromal cell...
Glomus tumors (GTs) are rare mesenchymal neoplasms that occur predominantly on the subungual region of distal extremities and rarely seen in visceral organs such as gastrointestinal tract. Malignant glomus (MGTs) is even more rare, comprising less than 1% all GTs. We reported an 82-year-old female patient with MGTs jejunum, accompanied by metastases to liver peritoneum. The presented a primary complaint epigastric pain nausea acid reflux for two months. Computed tomography scan revealed...
Abstract While lipoplex (cationic lipid‐nucleic acid complex)‐mediated intracellular delivery is widely adopted in mammalian cell transfection, its transfection efficiency for suspension cells, e.g., lymphatic and hematopoietic reported at only ≈5% or even lower. Here, efficient consistent lipoplex‐mediated demonstrated hard‐to‐transfect cells via a single‐cell, droplet‐microfluidics approach. In these microdroplets, monodisperse lipoplexes effective gene are generated chaotic mixing induced...
Cost-efficient saccharification is one of the main bottlenecks for industrial lignocellulose conversion. Clostridium thermocellum naturally degrades efficiently using cellulosome, a multiprotein supermolecular complex, and thus can be potentially used as low-cost catalyst saccharification. The use C. restrained due largely to inhibition hydrolysate cellobiose its cellulosome. Although supplementation beta-glucosidase may solve problem, production enzymes greatly complicates process also...
Circulating tumor cells (CTCs) are single cancer or cell clusters that present in the circulatory system. Assessing CTC levels patients can aid early detection of metastasis and is essential for purposes accurate prognosis. However, current vitro blood tests limited by insufficient samples low concentration CTCs, which presents a major challenge practical biosensing devices. In this work, we propose first surface plasmon resonance (SPR) fiber probe to work intravenously, offers real-time...
The σ70 family alternative σI factors and their cognate anti-σI are widespread in Clostridia Bacilli play a role heat stress response, virulence, polysaccharide sensing. Multiple σI/anti-σI exist some lignocellulolytic clostridial species, specifically for regulation of components multienzyme complex, termed the cellulosome. unique, because C-terminal domain (SigIC) N-terminal inhibitory (RsgIN) lack homology to known proteins. Here, we report structure interaction studies pair factors,...
A novel ratio-adjustable centrifugal droplet fusion platform dedicated to micro-reactor applications.
Pristimerin, a natural flavonoid compound, has potential anti-tumor activities. These activities have been illustrated in various cancer cell lines, including MDA-MB-231 cells. cells are representative mesenchymal subtype of triple negative breast (MES-TNBC) line. Currently, the main treatment for patients with advanced MES-TNBC is cytotoxic chemotherapy. We tried to examine role and effect pristimerin on epithelial-mesenchymal transition (EMT) cells.The effects proliferation were...
Semaphorin 5A (
Helicobacter pylori (H. pylori) infection is the strongest risk factor for occurrence and development of gastric carcinoma. However, molecular mechanism underlying H. pylori-induced pathogenesis has not yet been fully characterized. Here, we explored whether upregulates semaphorin 5A to promote cancer progression via extracellular regulated protein kinases/matrix metalloproteinase (ERK/MMP9) signaling pathway. In this study, upregulated expression in vitro vivo. Using human carcinoma cell...
Recent technological advancements on stem cell differentiation induction have been making great progress in research, regenerative medicine, and therapeutic applications. However, the risk of off-target limits wide application therapy strategies. Here, we report a non-invasive all-optical strategy to induce vitro vivo that activates individual target cells situ by delivering transient 100-ms irradiation tightly focused femtosecond laser submicron cytoplasmic region primary adipose-derived...
The blood pressure signal is weak nonstationary biomedicine signal. Wavelet analysis used to pick up the character of for useful information and truth oscillation amplitude artery curve reckoned by fuzzy inference method. Sequentially, exact relation between cuff developed this fitted with recursive least square Finally systolic diastolic are calculated wave threshold With wavelet method, interference resulted from cardiovascular disease or movement on measuring effectively decreased...
Warthin-like mucoepidermoid carcinoma (WL-MEC) is a newly reported variant of carcinoma. Its histological feature easy to confused with metaplastic Warthin Tumor, and its relationship tumor in histogenesis controversial. In this study, we presented two cases WL-MEC, discussing their clinicopathological molecular features. Notably, one case was initially misdiagnosed during the first onset tumor. Case 1 60-year-old female mass right parotid gland. 2 featured 29-year-old male who developed...
Abstract Hepatocellular carcinoma (HCC) is the most common histological subtype in primary liver cancer. This study aimed to develop a miRNA-correlated (MIRcor) gene signature, which provided theoretical foundation for prognosis and therapy of patients with HCC. The MIRcor genes HCC were obtained using correlation analysis miRNA-mRNA relationship pairs extracted from three databases. Subsequently, consensus clustering was performed samples based on differentially expressed (DEGs) between...
In this study, we introduce a cost-effective and high-throughput microfluidic system capable of generating uniform droplet reactors conducting real-time analysis single-cell morphology apoptosis. This holds great promise in the fields biological research personalized disease treatment.
To identify the epithelial cell centre regulatory transcription factors in gastric cancer (GC) microenvironment and provide a new strategy for diagnosis treatment of GC. The GC single-cell dataset was downloaded from Gene Expression Omnibus (GEO) database. mechanisms both pan-cancer microenvironments were analysed using Cancer Genome Atlas (TGCA) Real-time quantitative PCR (RT-qPCR) used to determine mRNA expression levels Prospero homeobox gene 1 (PROX1) Endothelial PAS domain-containing...
Increasing evidence supports the connection between progression of several cancers and BRK1. However, clinical significance aberrant BRK1 gene expression in cancer is unknown. This study conducted to investigate possibility effect as a potential immunotherapy target, deliver better option for liver immunotherapy. We explored predictive role variety from different bioinformatics, including differential cancers, tumor microenvironment (TME), microsatellite instability (MSI), mutational burden...