A5005495265- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Memory and Neural Mechanisms
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Circadian rhythm and melatonin
- Exercise and Physiological Responses
- Xenotransplantation and immune response
- Maternal Mental Health During Pregnancy and Postpartum
- Adenosine and Purinergic Signaling
- Sperm and Testicular Function
- Bipolar Disorder and Treatment
- Health, psychology, and well-being
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- interferon and immune responses
The University of Adelaide
2014-2021
Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties heritability estimate of up to 61%. The circulating levels IL-6 in blood have been associated an increased risk complex disease pathogenesis. We conducted two-staged, discovery replication meta genome-wide association study (GWAS) serum comprising 67 428 (ndiscovery = 52 654 nreplication 14 774) individuals European ancestry. inverse variance fixed effects based meta-analysis, followed...
The known effects of aging on the brain and behavior include impaired cognition, increases in anxiety depressive-like behaviors, reduced locomotor activity. Environmental exposures interventions also influence functions during aging. We investigated normal under controlled environmental conditions absence external activity, immune function hippocampal gene expression C57BL/6 mice. Healthy mice at 4, 9, 14 months age underwent behavioral testing using an established battery, followed by...
Environmental enrichment (EE) has been shown to modulate behavior and immunity. We recently reported that both short long-term EE enhance baseline locomotion alleviate depressive-like behavior, but only affects adversely in a threatening environment enhances anxiety-like middle-age mice. have now investigated whether the observed changes after short- were associated with underlying immune changes. Hence, at end of behavioral testing, mice sacrificed, brains cervical lymph nodes collected...
Abstract Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort 3-, 8-, 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, or groups provided with no treatment, running wheel, variety plastic wooden objects alone in combination wheel for seven weeks, respectively....