A5031986953- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Immunotherapy and Immune Responses
- Glaucoma and retinal disorders
- Lymphatic System and Diseases
- Salivary Gland Disorders and Functions
- Angiogenesis and VEGF in Cancer
- Ocular Infections and Treatments
- Immune Response and Inflammation
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Advancements in Transdermal Drug Delivery
- T-cell and B-cell Immunology
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Hematopoietic Stem Cell Transplantation
- Dermatology and Skin Diseases
- Nasolacrimal Duct Obstruction Treatments
- Biochemical Analysis and Sensing Techniques
Islamic Azad University Central Tehran Branch
2023
Massachusetts Eye and Ear Infirmary
2002-2022
Harvard University
2001-2022
Smith-Kettlewell Eye Research Institute
2000-2009
Harvard University Press
2004-2008
Singapore Eye Research Institute
1998-2007
Brigham and Women's Hospital
1997-2005
New England College of Optometry
2000-2003
Eunice Kennedy Shriver Center
2000-2002
Prevent Blindness
2002
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 VEGFR2 essential hemangiogenic factor. We re-evaluated potential role lymphangiogenesis using a novel model which both hemangiogenesis are induced normally avascular cornea. Administration VEGF Trap, receptor-based fusion protein that neutralizes but not or -D, completely inhibited outgrowth LYVE-1(+) lymphatic...
To evaluate the occurrence and time course of hem- lymphangiogenesis after normal-risk corneal transplantation in mouse model to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival.Normal-risk allogeneic (C57BL/6 BALB/c) syngeneic (BALB/c transplantations were performed keratoplasty was observed, by using double immunofluorescence flatmounts (with CD31 as a panendothelial LYVE-1 lymphatic vascular endothelium-specific marker). A molecular trap...
purpose. Dendritic cells (DCs) comprise a system of highly efficient antigen-presenting (APCs) that initiate immune responses. The purpose this study was to examine the normal stroma for presence DCs and other bone marrow (BM)–derived cells. methods. Normal uninflamed corneas BALB/c murine strains were excised, immunofluorescence single- double-staining multiple markers performed examination by confocal microscopy. Corneal buttons placed in culture immunocytochemistry flow cytometry...
To study the efficacy of topical application alpha-linolenic acid (ALA) and linoleic (LA) for dry eye treatment.Formulations containing ALA, LA, combined ALA or vehicle alone, were applied to eyes induced in mice. Corneal fluorescein staining number maturation corneal CD11b(+) cells determined by a masked observer different treatment groups. Real-time polymerase chain reaction was used quantify expression inflammatory cytokines cornea conjunctiva.Dry induction significantly increased...
The purpose of this study was to determine whether the chronic use antiandrogen medications leads meibomian gland dysfunction, altered lipid profiles in secretions, decreased tear film stability, and evaporative dry eye. Subjects taking therapy for prostatic indications, as well age-related controls, were asked complete a questionnaire that assessed eye symptoms then given anterior segment examination. Moreover, secretions obtained from each analyzed by high-performance liquid...
To examine the widely accepted dogmas that corneal grafts lack passenger leukocytes or cells capable of migrating directly to lymph nodes (LNs), we tracked migration graft-derived transgenic green fluorescent protein (GFP; Iab) into draining LNs allogeneic (Iad) recipients. GFP+ were identified in cervical several hours after transplantation, and this traffic was significantly enhanced when placed inflamed recipient beds. Draining Iab+, CD45+, CD11c+, examination ungrafted corneas revealed...
purpose. To develop a controlled-environment chamber (CEC) for mice and verify the effects of low-humidity setting on ocular surface signs in normal mice. methods. Eight- to 12-week-old BALB/c were used where relative humidity (RH), temperature (T), airflow (AF) are regulated monitored. Mice placed into CEC exposed specific environmentally controlled conditions (RH = 18.5% ± 5.1%, AF 15 L/min, T 21–23°C) 3, 7, 14, 28 days. Control kept environment 50%–80%, no AF, same duration. Aqueous tear...
<h3>Objective</h3> To evaluate whether hemangiogenesis, lymphangiogenesis, and concomitant invasion of mononuclear phagocytes occurring after high-risk corneal transplantation in already vascularized recipient beds increase the risk for subsequent immune rejection. <h3>Methods</h3> Three intrastromal sutures were left place 6 weeks corneas BALB/c mice, causing neovascularization. suture removal, keratoplasty was performed (donors C57BL/6 mice). The treatment group received a vascular...
purpose. Thrombospondin (TSP)-1 and -2 are important antiangiogenic factors thought to be involved in maintaining corneal avascularity (angiogenic privilege). This study was undertaken investigate whether deficiencies of these altered developmental inflammation-induced angiogenesis the cornea iris mice. methods. Expression TSP-1 mRNA protein assayed stroma by RT-PCR Western blot. Corneas irides TSP-1−/−, TSP-2−/−, TSP-1,2−/− mice aged 2, 3, 6 months, wild-type control mice, were analyzed for...