A5037205866- Epigenetics and DNA Methylation
- Hair Growth and Disorders
- Cancer-related gene regulation
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Dermatology and Skin Diseases
- Cancer Mechanisms and Therapy
- Wound Healing and Treatments
- Viral Infections and Vectors
- Reproductive System and Pregnancy
- HIV Research and Treatment
- Ovarian function and disorders
- Skin Protection and Aging
- Mesenchymal stem cell research
- Contact Dermatitis and Allergies
- Cancer Cells and Metastasis
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Laser Applications in Dentistry and Medicine
- Aquaculture disease management and microbiota
- Synthesis and biological activity
- melanin and skin pigmentation
- Inflammatory mediators and NSAID effects
National Taiwan University
2011-2024
Academia Sinica
2014-2024
Genomics Research Center, Academia Sinica
2012
National Health Research Institutes
2004-2008
Azabu University
2004
University of Utah
1994
Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors derived from human embryonic (hESCs). Recently, long non-coding RNAs (lncRNAs), delta-like homolog 1 gene and type III iodothyronine deiodinase (DLK1-DIO3) imprinted locus-derived maternally expressed 3 (MEG3), were found be during development. The deregulation these lncRNAs is associated with various neurological diseases. locus DLK1-DIO3 encodes abundant (ncRNAs)...
The outer surface lipoproteins of Borrelia burgdorferi, OspA and OspB, stimulate the production nitric oxide (NO) by murine bone marrow-derived macrophages from BALB/c, C3H/HeN, C3H/HeJ mice. Gamma interferon (IFN-gamma) caused a three- to fivefold enhancement this NO, L-arginine analog N-guanidino-monomethyl inhibited it. Activation transcription inducible NO synthase gene in stimulated was demonstrated reverse transcriptase rapid PCR. Although IFN-gamma increased amount produced macrophage...
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Although its aetiology and pathogenesis remain unclear, recent studies suggest that dysfunction granulosa cells may partly be responsible. This study aimed to use cDNA microarray technology compare cell gene expression profiles with without PCOS identify genes aetiologically implicated PCOS. The cohort included 12 undergoing vitro fertilization, six Differential were classified by...
Borrelia burgdorferi produces potent cell-activating molecules capable of stimulating polyclonal proliferation and immunoglobulin production by murine B lymphocytes cytokine a variety cell types. These stimulatory function in infected mice, resulting elevated levels circulating immunoglobulins serum interleukin-6. We have recently demonstrated that the purified outer surface lipoproteins OspA OspB possess these properties. To assess their possible involvement human disease, we determined...
Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR colorectal (CRC) by disclosing increased activity CRC patients its enhancement anti-apoptosis stemness. Our previous studies showed that statins containing carboxylic acid chains possessed against histone deacetylases (HDACs), strengthened their anti-HDAC through designing...
Mammalian genomes are replete with retrotransposable elements, including endogenous retroviruses. DNA methyltransferase 3-like (DNMT3L) is an epigenetic regulator expressed in prospermatogonia, growing oocytes, and embryonic stem (ES) cells. Here, we demonstrate that DNMT3L enhances the interaction of repressive modifiers, histone deacetylase 1 (HDAC1), SET domain, bifurcated (SETDB1), 3A (DNMT3A), tripartite motif-containing protein 28 (TRIM28; also known as TIF1β KAP1) ES cells...
Nucleotide sequencing after TA cloning of the amplicon almost-full length recA gene from three strains UPTC (A1, A2, and A3) isolated seagulls in Northern Ireland, phenotypical genotypical characteristics which have been demonstrated to be indistinguishable, clarified nucleotide differences at positions among strains. In conclusion, sequences were found discriminate UPTC, A1, A3, are indistinguishable phenotypically genotypically. Thus, present study strongly suggests that sequence data a...
Abstract In the last 5 years, prevalence of colorectal cancer (CRC) has increased worldwide and surpassed that liver cancer. Even after treatment for primary CRC, patients still have a high risk (30%–50%) recurrence, generally from metastasis. Thus, if we can uncover progressive mechanisms CRC identify novel drug target, current regimens survival with advanced stage be improved. Euchromatin histone lysine N-methyl transferase 2 (EHMT2) inhibition is considered an effective therapeutic...
The instability of genomic imprinting in pluripotent stem cells plants risk cancer formation after cell based regenerative medical treatment, as many imprinted genes, such Igf2, H19, and Igf2r, are involved growth control their deregulation is highly associated with carcinogenesis. Furthermore, defects at Dlk1-Dio3 locus have been shown to correlate loss "full" pluripotency mouse ES (embryonic stem) iPS (induced cells. Our data from analyzing different passages NTU1 human embryonic (ES) line...