A5101788970- Influenza Virus Research Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Galaxies: Formation, Evolution, Phenomena
- Fire effects on ecosystems
- Cosmology and Gravitation Theories
- Viral Infections and Outbreaks Research
- Atmospheric chemistry and aerosols
- Zoonotic diseases and public health
- Air Quality and Health Impacts
- Metal complexes synthesis and properties
- Malaria Research and Control
- Air Quality Monitoring and Forecasting
- Gamma-ray bursts and supernovae
- Black Holes and Theoretical Physics
- SARS-CoV-2 and COVID-19 Research
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Virus-based gene therapy research
- Dengue and Mosquito Control Research
Institute of Microbiology
2022-2025
North Minzu University
2024
Chinese Academy of Sciences
2022-2024
State Key Laboratory of Remote Sensing Science
2015-2024
Beijing Normal University
2015-2024
National Institute for Viral Disease Control and Prevention
2016-2023
State Forestry and Grassland Administration
2023
University of Chinese Academy of Sciences
2023
University of Edinburgh
2023
Shanxi Agricultural University
2023
The incidence of dengue has grown dramatically in recent decades worldwide, especially Southeast Asia and the Americas with substantial transmission 2014–2015. Yet mechanisms underlying spatio-temporal circulation virus (DENV) serotypes at large geographical scales remain elusive. Here we investigate co-circulation DENV 1–3 from 1956 to 2015, using a statistical framework that jointly estimates migration history quantifies potential predictors viral spatial diffusion, including...
Hantavirus, a rodent-borne zoonotic pathogen, has global distribution with 200,000 human infections diagnosed annually. In recent decades, repeated outbreaks of hantavirus have been reported in Eurasia and America. These led to public concern an interest understanding the underlying biological mechanisms. Here, we propose climate-animal-Hantaan virus (HTNV) infection model address this issue, using unique dataset spanning 54-y period (1960-2013). This comes from Central China, focal point...
The recent rise in the frequency of influenza A(H5N6) infections China has raised serious concerns about whether risk for human infection increased. We surveyed epidemiologic, clinical, and genetic data with viruses. Severe disease occurred 93.8% cases, fatality rate was 55.4%. Median patient age 51 years. Most H5N6 hemagglutinin (HA) genes isolates 2021 originated from subclade 2.3.4.4b; we estimated time to most common ancestor as June 16, 2020. A total 13 genotypes HA multiple subclades...
Zoonoses are increasingly recognized as an important burden on global public health in the 21st century. High-resolution, long-term field studies critical for assessing both baseline and future risk scenarios a world of rapid changes. We have used three-decade-long study hantavirus, rodent-borne zoonotic pathogen distributed worldwide, coupled with epidemiological data from endemic area China, show that shift ecological dynamics Hantaan virus was closely linked to environmental fluctuations...
Africa carries a disproportionately high share of the global malaria burden, accounting for 94% cases and deaths worldwide in 2019. It is also politically unstable region most vulnerable continent to climate change recent decades. Knowledge about modifying impacts violent conflict on climate–malaria relationships remains limited. Here, we quantify associations between conflict, variability, risk sub-Saharan using health surveys from 128,326 individuals, historical data, 17,429 recorded...
Porcine epidemic diarrhea virus ( PEDV ), a leading cause of piglet outbreaks, poses significant danger to the swine industry. The aim this study was investigate characteristics that circulating in Guangdong province, one China’s major pig producing provinces. Clinical samples were collected from eight farms province between 2018 and 2019 tested for porcine enteric pathogens, including , transmissible gastroenteritis TGEV) Swine coronavirus SeCoV) acute syndrome SADS-CoV) deltacoronavirus...
Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds China November 2021. The probably evolved among wild through different flyways connecting Europe and Asia. Their low antigenic reaction to vaccine antiserum indicates high risks poultry public health.
In late 2023, the first human case caused by an H10N5 avian influenza virus (AIV) was diagnosed in China. H10Ny AIVs have been identified various poultry and wild birds Eurasia, Americas, Oceania. We analyzed clinical data of AIV-infected patient, isolated virus, evaluated receptor-binding properties together with H10N8 H10N3 humans poultry. The genomic human-infecting strain (n = 48, including 16 strains 2 H10N8) from live markets China, during 2019-2021, were sequenced. inferred genetic...
Abstract Yersinia pestis is transmitted from fleas to rodents when the bacterium develops an extensive biofilm in foregut of a flea, starving it into feeding frenzy, or, alternatively, during brief period directly after on bacteremic host. These two transmission modes are trade-off regulated by amount produced bacterium. Here investigating 446 global isolated Y. genomes, including 78 newly sequenced isolates sampled over 40 years plague focus China, we provide evidence for strong selection...
AbstractThe first human infection with severe fever thrombocytopenia syndrome virus (SFTSV) was detected in Shaanxi Province, China, 2013, although the had been reported 13 other provinces of China since 2010. We collected and analyzed a total 4,011 samples, including 936 serum 155 animal 895 ticks, 1,950 mosquitoes, 30 midges, 20 sandflies. SFTSV antibodies were found 44 samples (4.7%) no significant differences between males females or across counties. The incidence rate significantly...
Dengue transmission in urban areas is strongly influenced by a range of biological and environmental factors, yet the key drivers still need further exploration. To better understand mechanisms environment-mosquito-urban dengue transmission, we propose an empirical model parameterized cross-validated from unique dataset including viral gene sequences, vector dynamics human cases Guangzhou, China, together with 36-year change maps investigated spatiotemporal satellite image fusion. The...
The 2016–2017 epidemic of influenza A (H7N9) virus in China prompted concern that a genetic change may underlie increased virulence. Based on an evolutionary analysis H7N9 viruses from all five outbreak waves, we find additional subclades the H7 and N9 genes have emerged. Our indicates inherited NP co-circulating instead H9N2 viruses. Genotypic diversity among following wave I, peaked during III, rapidly deceased thereafter with minimal V, suggesting entered relatively stable stage. ZJ11...
Model-based phylodynamic approaches recently employed generalized linear models (GLMs) to uncover potential predictors of viral spread. Very some these have allowed both the and their coefficients be time-dependent. However, studies mainly focused on that are assumed constant through time. Here we inferred phylodynamics avian influenza A virus H9N2 isolated in 12 Asian countries regions under discrete trait analysis (DTA) structured coalescent (MASCOT) approaches. Using MASCOT applied a new...
During an investigation in October 2018, two people with diarrhoea, mild abdominal pain, and arthralgia symptoms Guangxi, China, were identified as infected by H9N2 avian influenza virus (AIV). Four AIVs isolated from one of patients, a pet cat, dead chicken (two respective isolates its lung kidney tissues) bred the patients at backyard farm. Epidemiological indicated that newly bought died first, clinical syndromes appeared subsequently owners cat. Furthermore, individuals possessed high...
We propose a new model for the viscosity of cosmic matters, which can be applied to different epochs universe. Using this model, we include bulk viscosities as practical corrections perfect fluid models baryonic and dark matters since material fluids in real world may have due thermodynamics. Such inclusion is put test within framework $f(T)$ gravity that proved successful describing acceleration, where $T$ denotes torsion scalar. perform an observational fit our constrain cosmological...
We collected 2768 Influenza-like illness emergency public health incidents from April 1, 2005 to November 30, 2013reported in the Emergency Public Reporting System. After screening by strict inclusion and exclusion criteria, there were 613 outbreaks analyzed with susceptible-exposed-infectious/asymptomatic-removed model order estimate proportion of asymptomatic individuals (p) effective reproduction number (Rt). The relation between Rt viral subtypes, regions, outbreak sites, populations,...
We conducted environmental surveillance to detect avian influenza viruses circulating at live poultry markets (LPMs) and farms in Guangxi Autonomous Region, China, where near the China-Vietnam border. From November through April 2017-2018 2018-2019, we collected samples from 14 LPMs, 4 farms, 5 households with backyard two counties of tested for A, H5, H7, H9 by real-time reverse transcription-polymerase chain reaction (rRT-PCR). In addition, four cross-sectional questionnaire surveys among...
After publication of the research paper[...]
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while avian viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs mammals. We find that H2 domestic poultry China have genetic antigenic differences compared A(H2N2)pdm1957. One AIV a dual receptor-binding property similar Molecular structural studies N144S, N144E or R137M substitutions hemagglutinin (HA)...