A5100425396- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Food composition and properties
- Geology and Paleoclimatology Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Echinoderm biology and ecology
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Metabolism and Genetic Disorders
- Antimicrobial Peptides and Activities
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Polysaccharides Composition and Applications
- Osteoarthritis Treatment and Mechanisms
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
Jiangsu Province Hospital
2024-2025
Hebei Medical University
2024-2025
Fourth Hospital of Hebei Medical University
2024-2025
Shandong Provincial Hospital
2020-2025
Texas A&M University
2020-2025
Shandong First Medical University
2020-2025
China Agricultural University
2023-2025
Sun Yat-sen University
2019-2024
Sun Yat-sen University Cancer Center
2019-2024
Ocean University of China
2019-2024
Abstract. In the summer of 2017, heavy ozone pollution swamped most North China Plain (NCP), with maximum regional average daily 8 h concentration (MDA8) reaching almost 120 ppbv. light continuing reduction anthropogenic emissions in China, underlying mechanisms for occurrences these extreme episodes are elucidated from two perspectives: meteorology and biogenic emissions. The significant positive correlation between MDA8 temperature, which is amplified during heat waves concomitant stagnant...
Abstract Hepatic arterial infusion chemotherapy (HAIC) using a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown promise for hepatocellular carcinoma (HCC) patients classified under Barcelona Clinic Liver Cancer (BCLC) stage C. In China, the combined therapy camrelizumab apatinib is now an approved first-line approach inoperable HCC. This study (NCT04191889) evaluated benefit combining with HAIC-FOLFOX HCC in BCLC Eligible were given maximum six cycles HAIC-FOLFOX,...
Abstract Autophagy defection contributes to inflammation dysregulation, which plays an important role in gastric cancer (GC) progression. Various studies have demonstrated that long noncoding RNA could function as novel regulators of autophagy. Previously, MALAT1 was reported upregulated GC cells and positively regulate autophagy various cancers. Here, we for the first time found promote interleukin-6 (IL-6) secretion by blocking autophagic flux. Moreover, IL-6 induced activate normal...
Abstract A critical step in lipopolysaccharide (LPS) biogenesis involves flipping lipooligosaccharide, an LPS precursor, from the cytoplasmic to periplasmic leaflet of inner membrane, operation carried out by ATP-binding cassette transporter MsbA. Although binding cavity MsbA is well established, selectivity MsbA-lipid interactions at other site(s) remains poorly understood. Here we use native mass spectrometry (MS) characterize and guide structural studies. We show co-purifies with...
Abstract It has been confirmed that BTB domain and CNC homologue 1 (BACH1) are involved in ferroptosis‐related diseases. However, the function of BACH1 cerebral ischemia–reperfusion injury (CIRI)‐induced ferroptosis remains to be largely unrevealed. First, analysis differentially expressed genes CIRI based on GEO dataset GSE119121 revealed was upregulated CIRI. level prominently increased middle artery occlusion (MCAO)/reperfusion model oxygen–glucose deprivation/reoxygenation cell model....
Six new quassinoids (1–6) and eight known compounds of this type (7–14) were isolated from the seeds Brucea javanica. Their structures elucidated by analysis their spectroscopic data chemical evidence. Compounds 1–5 found to be unusual with a 2,3-seco A ring. The configurations at C-4 in 4 5 determined difference circular dichroism method. In vitro bioassays, 8 10 showed inhibitory activities for nitric oxide production LPS-activated macrophages, IC50 values 1.9 5.0 μM, respectively, while...
Constrained optimization is popularly seen in reinforcement learning for addressing complex control tasks. From the perspective of dynamic system, iteratively solving a constrained problem can be framed as temporal evolution feedback system. Classical methods, such penalty and Lagrangian approaches, inherently use proportional integral controllers. In this paper, we propose more generic equivalence framework to build connection between purpose developing effective RL algorithms. Firstly,...
Objective Our previous study found that Achaete-scute complex homolog 1 (ASCL1) is involved in classifying BC subtypes with different prognostic and pathological characteristics. However, the biological role of ASCL1 still remains largely unexplored. This aims to elucidate function using bioinformatics analyses, as well vitro vivo experimental approaches. Methods Data from TCGA, GEO, Human Protein Atlas databases were utilized evaluate expression its association patient prognosis. Genetic...
The Rho-associated protein kinase (ROCK) inhibitor Y-27632 is a potential immunotherapeutic agent for cancer treatment. blocks the growth and migration of oral squamous cell carcinoma (OSCC) CAL-27 cells. However, detailed studies on underlying mechanisms have not yet been reported. We investigated effects proliferation, migration, invasion OSCC cells (CAL-27, SCC-4, SCC-9) using Cell Counting Kit-8 assay, ethynyl-2'-deoxyuridine staining, scratch, transwell assay in vitro. Next, ROCK1/2 was...
We have previously found that S100 calcium-binding protein A7 (S100A7) is strongly associated with chemoresistance in breast cancer (BC). In this study, we investigated whether S100A7 can be used to predict the efficacy of neoadjuvant chemotherapy (NAC) and assessed its relationship clinicopathological characteristics BC. retrospectively analyzed data patients BC who underwent NAC at Fourth Hospital Hebei Medical University between January 2021 December 2021. The t-test, Wilcoxon test,...
The MAPK pathway is a crucial cell-signaling cascade that composed of RAS, MEK, BRAF, and ERK, which serves to connect extracellular signals intracellular responses. Over-activating mutations in the can lead uncontrolled cell growth ultimately resulting various types cancer. While this has been heavily studied using battery techniques, herein we employ native mass spectrometry (MS) characterize pathway, including nucleotide, drug, protein interactions. We utilize MS provide detailed insights...
This study aimed to assess the association between perceived social support (PSS) and fatigue roles of hope, optimism, general self-efficacy resilience as mediators or moderators on PSS-fatigue among Rheumatoid Arthritis (RA) patients in China.A multi-center, cross-sectional was conducted withinpatients diagnosed with RA northeast China, which 305 eligible inpatients were enrolled. The Multidimensional Fatigue Inventory, Scale Perceived Social Support, Herth Hope Index, Life Orientation Test...
Abstract Aromatics in the atmosphere are a large contributor to ozone and secondary organic aerosol formation have an adverse impact on human health. Observation‐based emissions urgently needed for air quality management decision making due uncertainties inventories. Atmospheric aromatics were continuously observed at one urban site Shanghai of China 2015, which compared with simulations Community Multiscale Air Quality (CMAQ) model. Large differences found temporal variations between model...
While it is known that lipids play an essential role in regulating membrane protein structure and function, remains challenging to identify specific protein–lipid interactions.
Ischemia‒reperfusion (I/R) injury is a frequently observed complication after flap surgery, and it affects skin survival patient prognosis. Currently, there are no proven safe effective treatment options to treat I/R injury. Herein, the potential efficacies of bioactive peptide from maggots (BPM), as well its underlying mechanisms, were explored in rat model LPS- or H
The recent years have witnessed the rapid advancement of clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9)-mediated gene editing in cancer therapy. success therapy relies heavily on development safe and effective delivery vectors. We focus organic nanocarriers because their flexible customizability, which permits them to accomplish excellent efficiency performance. In this review, pharmacokinetic behavior CRISPR/Cas9 serves as a guide outline...