A5031435816- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Advanced Fluorescence Microscopy Techniques
- Neurobiology and Insect Physiology Research
- Ophthalmology and Eye Disorders
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Multilingual Education and Policy
- Radiation Dose and Imaging
- EFL/ESL Teaching and Learning
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect symbiosis and bacterial influences
- Insect and Arachnid Ecology and Behavior
- Visual perception and processing mechanisms
- Circadian rhythm and melatonin
- Cardiac Imaging and Diagnostics
- Glaucoma and retinal disorders
- Second Language Learning and Teaching
- International Development and Aid
University of California, Los Angeles
2024
Max Planck Institute for Biological Cybernetics
2022-2024
University of Arizona
2024
Harvard University
2009-2020
Eli Lilly (United Kingdom)
2015-2020
University of British Columbia
2019
Harvard University Press
2019
Rowland Foundation
2018
Broad Institute
2017
RAND Corporation
2016
To investigate the role of host cytoskeleton in maternal transmission endoparasitic bacteria Wolbachia, we have characterized their distribution female germ line Drosophila melanogaster. In germarium, Wolbachia are distributed to all cells cyst, establishing an early infection cell destined become oocyte. During mid-oogenesis, exhibit a distinct concentration between anterior cortex and nucleus oocyte, where many appear contact nuclear envelope. Following programmed rearrangement microtubule...
Abstract Multiple scattering and absorption limit the depth at which biological tissues can be imaged with light. In thick unlabeled specimens, multiple randomizes phase of field attenuates light that travels long optical paths. These obstacles performance transmission imaging. To mitigate these challenges, we developed an epi-illumination gradient interference microscope (epi-GLIM) as a label-free imaging modality applicable to bulk or opaque samples. Epi-GLIM enables studying turbid...
Spatial learning in teleost fish requires an intact telencephalon
One of the most prominent features at mid-blastula transition (MBT)observed in embryos is a pause cell cycle regulated by nucleocytoplasmic (N/C) ratio. By using chromosome rearrangements to manipulate DNA content embryos, we determined that threshold for this Drosophila about 70% normally present 14. Embryos with contents around value show intermediate behaviors. Some 14, some 15,and form patches arrested different mitotic cycles. A second feature MBT massive increase zygotic transcription...
Clinical guidelines and scientific data increasingly support the appropriate use of cardiovascular magnetic resonance (CMR) . The extent CMR adoption across United States (US) remains unclear. This observational analysis aims to capture practice patterns in US. Commissioned reports from Society for Cardiovascular Magnetic Resonance (SCMR), pre-existing survey centers, socioeconomic coronary heart disease Centers Disease Control Prevention were used. location imaging centers performing was...
Within reflex circuits, specific anatomical projections allow central neurons to relay sensations effectors that generate movements. A major challenge is relate features of neural populations, such as asymmetric connectivity, the computations populations perform. To address this problem, we mapped anatomy, modeled function, and discovered a new behavioral role for genetically defined population vestibular in rhombomeres 5–7 larval zebrafish. First, found within project preferentially...
Defining the structural and functional changes in nervous system underlying learning memory represents a major challenge for modern neuroscience. Although neuronal activity following formation have been studied [B. F. Grewe et al.,
Abstract Research has demonstrated that students in dual‐language immersion programs perform as well as, or better than, their peers core academic content areas by late elementary school. However, the extent to which education fosters bilingualism received less attention literature. Using data from a four‐year efficacy study of Portland Public Schools Oregon, this reports skill levels 1,284 achieved classroom partner languages (Spanish, Japanese, and Mandarin Chinese) between third eighth...
Abstract Neuronal activity elicits metabolic and vascular responses, during which oxygen is first consumed then supplied to the tissue via an increase in cerebral blood flow. Understanding spatial temporal dynamics of ( ) responses following neuronal crucial for understanding physiological basis functional neuroimaging signals. However, our knowledge limited because previous measurements have been made at low resolution (>100 ms). Here we recorded high (1 ms), simultaneously with...
While resting-state functional magnetic resonance imaging can probe intrinsic network connectivity in both human and rodent brain, behavioral modulation of these patterns has not yet been demonstrated the due to requirements immobilization or anesthesia for MRI scanning. To enable effects tasks on be measured freely moving, awake rats, implanted carbon paste electrodes (CPEs) were used monitor low-frequency fluctuations tissue oxygenation. Rats with CPEs two nodes default mode (DMN) a...