A5090624781- Genomics and Phylogenetic Studies
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- Landslides and related hazards
- Granular flow and fluidized beds
- Lung Cancer Research Studies
- Bioinformatics and Genomic Networks
- Insect and Arachnid Ecology and Behavior
- Malaria Research and Control
- Cancer Immunotherapy and Biomarkers
- Recommender Systems and Techniques
- Cancer therapeutics and mechanisms
- Mosquito-borne diseases and control
- Insect and Pesticide Research
- Insect symbiosis and bacterial influences
- Multimedia Communication and Technology
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Genomics and Chromatin Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Invertebrate Immune Response Mechanisms
- Scientific Computing and Data Management
- Gene expression and cancer classification
- Lung Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
Pennsylvania State University
2015-2024
Massachusetts Institute of Technology
2024
Budapest University of Technology and Economics
2008-2021
Montavid Thermodynamic Research Group
2012-2020
Center for Disease Dynamics, Economics & Policy
2019
Park University
2019
The BE Vedeneev All Russia Institute of Hydraulic Engineering
2017
Millennium Engineering and Integration (United States)
2016
Kindai University
2011
Semmelweis University
2011
In an early-phase study involving patients with advanced non–small-cell lung cancer (NSCLC), the response rate was better nivolumab plus ipilimumab than monotherapy, particularly among tumors that expressed programmed death ligand 1 (PD-L1). Data are needed to assess long-term benefit of in NSCLC.
Accessing and analyzing the exponentially expanding genomic sequence functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines power of existing genome annotation databases with simple Web portal to enable users search remote resources, combine from independent queries, visualize results. The heart Galaxy is flexible history system stores queries each user; performs operations such as intersections, unions, subtractions; links...
The magnitude of the August 2003 blackout affecting United States has put challenges energy transmission and distribution into limelight. Despite all interest concerted effort, complexity interconnectivity electric infrastructure precluded us for a long time from understanding why certain events happened. In this paper we study power grid network perspective determine its ability to transfer between generators consumers when nodes are disrupted. We find that is robust most perturbations, yet...
Most nucleosomes are well-organized at the 5' ends of S. cerevisiae genes where "-1" and "+1" bracket a nucleosome-free promoter region (NFR). How nucleosomal organization is specified by genome less clear. Here we establish inter-relate rules governing genomic nucleosome sequencing DNA from more than one million immunopurified (displayed http://atlas.bx.psu.edu/). Evidence presented that throughout largely consequence statistical packing principles. The sequence specifies location -1 +1...
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, murine model of high-fat diet-induced (HFD-induced) was used, and effects alterations in on were determined. Mice treated with antibiotics or tempol exhibited altered bile acid composition, notable increase conjugated metabolites inhibited intestinal farnesoid X receptor (FXR) signaling. Compared control mice, animals...
Recommender systems have become valuable resources for users seeking intelligent ways to search through the enormous volume of information available them. One crucial unsolved problem recommender is how best learn about a new user. In this paper we study six techniques that collaborative filtering can use users. These select sequence items system present each user rating. The include theory will give most value system, aggregate statistics likely an opinion about, balanced seek maximize...
Recommender systems have changed the way people shop online. on wireless mobile devices may same impact in stores. We present our experience with implementing a recommender system PDA that is occasionally connected to network. This interface helps users of MovieLens movie recommendation service select movies rent, buy, or see while away from their computer. The results nine month field study show although there are several challenges overcome, potential provide value today
Recommender systems use people's opinions about items in an information domain to help people choose other items. These have succeeded domains as diverse movies, news articles, Web pages, and wines. The psychological literature on conformity suggests that the course of helping make choices, these probably affect users' If are influenced by recommendations, they might be less valuable for making recommendations users. Further, manipulators who seek system generate artificially high or low...
PURPOSE This phase III, multicenter, randomized, placebo-controlled trial assessed the efficacy and safety of sorafenib, an oral multikinase inhibitor, in combination with carboplatin paclitaxel chemotherapy-naïve patients unresectable stage IIIB or IV non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Nine hundred twenty-six were randomly assigned to receive up six 21-day cycles area under curve 6 200 mg/m(2) (CP) on day 1, followed by either sorafenib 400 mg twice a (n = 464, arm A)...
Collaborative filtering has proven to be valuable for recommending items in many different domains. In this paper, we explore the use of collaborative recommend research papers, using citation web between papers create ratings matrix. Specifically, tested ability citations that would suitable additional references a target paper. We investigated six algorithms selecting citations, evaluating them through offline experiments against database over 186,000 contained ResearchIndex. also...
Modern life sciences research increasingly relies on computational solutions, from large scale data analyses to theoretical modeling. Within the models Boolean networks occupy an increasing role as they are eminently suited at mapping biological observations and hypotheses into a mathematical formalism. The conceptual underpinnings of modeling very accessible even without background in quantitative sciences, yet it allows scientists describe explore wide range surprisingly complex phenomena....
Purpose This phase III trial was conducted to test whether the novel vascular disrupting agent ASA404 (vadimezan), when combined with first-line platinum-based chemotherapy, improves survival in patients advanced non–small-cell lung cancer (NSCLC) versus chemotherapy alone. Patients and Methods stage IIIB or IV NSCLC, stratified by sex tumor histology, were randomly assigned 1:1 paclitaxel (200 mg/m 2 ) carboplatin (area under curve, 6.0) without (1,800 mg m ), given intravenously once every...
BackgroundAlteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including obesity type 2 diabetes. Because most exposure environmentally persistent organic pollutants (POPs) occurs diet, host gastrointestinal tract commensal are likely be exposed POPs.ObjectivesWe examined effect 2,3,7,8-tetrachlorodibenzofuran (TCDF), a contaminant, on metabolism, we correlations between composition signaling...
To evaluate the efficacy and safety of dulanermin combined with paclitaxel carboplatin (PC) bevacizumab (PCB) as first-line treatment for advanced or recurrent non-small-cell lung cancer (NSCLC).Patients squamous NSCLC and/or CNS metastases received PC every 3 weeks alone (arm 1) 8 mg/kg 5 days 2). Patients nonsquamous PCB 3) 4) 20 2 5). The primary end point was objective response rate (ORR).Overall, 213 patients were randomly assigned 1, n = 41; arm 2, 39; 3, 42; 4, 40; 5, 41). ORR in arms...
Emerging and reemerging viruses are responsible for a number of recent epidemic outbreaks. A crucial step in predicting controlling outbreaks is the timely accurate characterization emerging virus strains. We present portable microfluidic platform containing carbon nanotube arrays with differential filtration porosity rapid enrichment optical identification viruses. Different strains (or unknown viruses) can be enriched identified real time through multivirus capture component conjunction...
Sunitinib plus erlotinib may enhance antitumor activity compared with either agent alone in non-small-cell lung cancer (NSCLC), based on the importance of signaling pathways involved tumor growth, angiogenesis, and metastasis. This phase III trial investigated overall survival (OS) for sunitinib versus placebo patients refractory NSCLC.Patients previously treated one to two chemotherapy regimens (including platinum-based regimen) recurrent NSCLC, whom was indicated, were randomly assigned...
Abstract Motivation: High-throughput protein interaction detection methods are strongly affected by false positive and negative results. Focused experiments needed to complement the large-scale validating previously detected interactions but it is often difficult decide which proteins probe as partners. Developing reliable computational assisting this decision process a pressing need in bioinformatics. Results: We show that we can use conserved properties of network identify validate...
The blood cancer T cell large granular lymphocyte (T-LGL) leukemia is a chronic disease characterized by clonal proliferation of cytotoxic cells. As no curative therapy yet known for this disease, identification potential therapeutic targets immense importance. In paper, we perform comprehensive dynamical and structural analysis network model disease. By employing reduction technique, identify the stationary states (fixed points) system, representing normal diseased behavior, analyze their...