The intracellular delivery of biofunctional enzymes or therapeutic proteins through systemic administration is great importance in intervention various diseases. However, current strategies face substantial challenges owing to biological barriers, including susceptibility protein degradation and denaturation, poor cellular uptake, low transduction efficiency into the cytosol. Here, we developed a biomimetic nanoparticle platform for proteins. Through biocompatible strategy, guest are caged...

Abstract Extracellular nanovesicles (ENV) released by many cells contain lipids, proteins, and nucleic acids that contribute to intercellular communication. ENVs have emerged as biomarkers therapeutic targets but they also been explored drug delivery vehicles. However, for the latter application, clinical translation has limited low yield inadequate targeting effects. ENV vectors with desired properties can be produced from parental engineered express membrane-bound ligands, or generated...

Abstract Bone metastasis occurs at ≈70% frequency in metastatic breast cancer. The mechanisms used by tumors to hijack the skeleton, promote bone metastases, and confer therapeutic resistance are poorly understood. This has led development of various models investigate interactions between cancer cells host marrow related physiological changes. However, it is challenging perform studies due difficulty periodic sampling. Herein, a bone‐on‐a‐chip (BC) reported for spontaneous growth 3D,...

Mitochondria play a critical role in diverse cellular processes, such as energy production and apoptosis regulation. The mitochondria-targeted drug delivery is becoming potential novel strategy for overcoming resistance cancer therapy. Herein, we synthesize nature-inspired dopamine-derived polydopamine (PDA) nanoparticles. Using triphenylphosphonium (TPP) the mitochondrial penetration molecule to improve target efficiency, poly(ethylene glycol) (PEG)-modified PDA (PDA-PEG) TPP-functionalized...

Fe(3)O(4)@SiO(2)@CeO(2) microspheres with magnetic core and mesoporous shell were synthesized, the multifunctional materials utilized to capture phosphopeptides catalyze dephosphorylation simultaneously, thereby labeling for rapid identification.

Viruses pose serious infectious disease threats to humans and animals. To significantly decrease the mortality morbidity caused by virus infections, there is an urgent need of sensitive rapid point-of-care platforms for detection, especially in low-resource settings. Herein, we developed a smartphone-based platform highly selective detection avian influenza based on nanomaterial-enabled colorimetric detection. The 3D nanostructures, which serve as scaffold antibody conjugation capture virus,...

In this paper, we propose a quantum interference mediated control of switching between magnon-atom entanglement and magnon blockade. A three-level $\mathrm{\ensuremath{\Lambda}}$ configuration atomic ensemble yttrium iron garnet sphere are simultaneously coupled to microwave cavity mode through magnetic dipole interaction. By applying two strong fields drive the atoms, resonant coupling dressed-state transition mode, without direct interaction, is established by adiabatically eliminating...

The flowerlike multifunctional affinity microspheres prepared by a facile solvothermal synthesis and subsequent calcination process consist of magnetic cores hierarchical meso-/macroporous TiO2 shells. porous structure the is constructed macroporous shell from stacked mesoporous nanopetals which are assembled small crystallites. have relatively large specific surface area 50.45 m(2) g(-1) superparamagnetism with saturation magnetization (Ms) value 30.1 emu g(-1). We further demonstrate that...

The graphene oxide (GO)–Fe3O4 and the reduced (rGO)–Fe3O4 composites with good water dispersibility, high affinity rapid magnetic response have been prepared via a facile grafting method. They can be used for effective immobilization of proteins enrichment peptides, respectively. By taking advantage loading capacity abundant hydrophilic groups GO–Fe3O4 composites, they applied to immobilize proteins. amount protein (BSA) on is as 294.54 mg g−1. rGO–Fe3O4 enrich low-concentration peptides...

A magnetic enzyme nanosystem have been designed and constructed by a polydopamine (PDA)-modification strategy. The has well defined core-shell structure relatively high saturation magnetization (Ms) value of 48.3 emu g−1. system can realize rapid, efficient reusable tryptic digestion proteins taking advantage its core biofunctional shell. Various standard (e.g. cytochrome C (Cyt-C), myoglobin (MYO) bovine serum albumin (BSA)) used to evaluate the effectiveness nanosystem. results show that...

We experimentally demonstrate enhanced third harmonic generation (THG) using a silicon metasurface, which is consist of symmetric spindle-shape nanoparticle array. Relying on the trapped mode supported by high quality factor all-dielectric conversion efficiency THG about 300 times larger than that bulk slab. The maximum extinction ratio intensity reaches 25 dB tuning polarization incident light. simulation results agree with experimental performances.

Mesoporous and hollow carbon microspheres embedded with magnetic nanoparticles (denoted as MHM) were prepared via a facile self-sacrificial method for rapid capture of low-abundant peptides from complex biological samples. The morphology, structure, surface property, magnetism well-characterized. have saturation magnetization value 130.2 emu g–1 at room temperature Brunauer–Emmett–Teller specific area 48.8 m2 an average pore size 9.2 nm the mesoporous shell. effectiveness these MHM affinity...

Successful control of homogeneous and complete coating graphene or graphene-based composites with well-defined metal organic framework (MOF) layers is a great challenge. Herein, novel magnetic MOF were constructed via simple strategy for self-assembly well-distributed, dense, highly porous MOFs on both sides nanosheets. Graphene functionalized nanoparticles carboxylic groups was explored as the backbone template to direct controllable MOFs. The prepared composite materials have relatively...

Mitochondria were used as a delivery system of carbon quantum dots for <italic>in vivo</italic> imaging and doxorubicin anticancer treatment.

Abstract Recent research has uncovered relation-based conceptual combination in L1 English speakers’ processing of noun–noun compounds. However, it remains unclear whether Chinese EFL learners undergo a similar when compounds, particularly given the similarities compounding between and Chinese. To address this inquiry, cohort 120 with advanced intermediate proficiency were requested to interpret compounds online contexts modifier-based relational information only, or both modifier- head...

We report on the generation of supercontinuum radiation from 2 to 20 μm in a 67 mm long GaAs crystal pumped by train 3 ps CO2 laser pulses. Temporal measurements indicate that sub-picosecond pulse splitting is involved production such wide-bandwidth GaAs. The results show observed spectral broadening heavily influenced four-wave mixing and stimulated Raman scattering.

We study photoelectron angular distributions (PADs) near the ionization threshold with a newly developed Coulomb quantum-orbit strong-field approximation (CQSFA) theory. The CQSFA simulations present an excellent agreement result from time-dependent Schr\"odinger equation method. show that low-energy fan-shaped structure in PADs corresponds to subcycle time-resolved holographic and stems significant influence of potential on phase forward-scattering electron trajectories, which affects...

We experimentally investigate the recoil-ion momentum distribution along laser polarization direction for nonsequential double ionization of Xe by 50 fs, 2400 nm pulses at intensities $(22\ensuremath{-}68) \mathrm{TW}/{\mathrm{cm}}^{2}$. The observed doubly charged ion exhibits a distinct transition from flat-top structure near zero longitudinal $22\phantom{\rule{0.16em}{0ex}}\mathrm{TW}/{\mathrm{cm}}^{2}$ to one with two maxima nonzero...

Abstract Rare‐earth phosphate microspheres with unique structures were developed as affinity probes for the selective capture and tagging of phosphopeptides. Prickly REPO 4 (RE=Yb, Gd, Y) monodisperse microspheres, that have hollow structures, low densities, high specific surface areas, large adsorptive capacities prepared by an ion‐exchange method. The elemental compositions crystal these confirmed energy‐dispersive spectroscopy (EDS), powder X‐ray diffraction (XRD), Fourier‐transform...

The 3 ps pulses are amplified to ~20 GW peak power in a TEA CO(2) laser using ac Stark broadening. Demonstration of such broadband coherent amplification 10 μm opens opportunities for powerful mid-IR source at high-repetition rate.

Abstract Novel core–shell structured Fe 3 O 4 @LnPO (Ln=Eu, Tb, Er) multifunctional microspheres with a magnetic core and LnPO shell covered spikes are synthesized for the first time through combination of homogeneous precipitation approach an ion‐exchange process. Their potential selective capture, rapid separation, easy mass spectrometry (MS) labeling phosphopeptides from complex proteolytic digests evaluated. These affinity can improve specificity capture phosphopeptides, realize fast...