A5101767867- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Pregnancy and preeclampsia studies
- Proteoglycans and glycosaminoglycans research
- Luminescence and Fluorescent Materials
- Molecular Biology Techniques and Applications
- Gestational Diabetes Research and Management
- Metal-Organic Frameworks: Synthesis and Applications
- Reproductive System and Pregnancy
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- RNA modifications and cancer
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fibroblast Growth Factor Research
- Ferroptosis and cancer prognosis
Soochow University
2019-2025
Second Affiliated Hospital of Soochow University
2019-2025
Studies have shown that cancer susceptibility candidate 11 (CASC11), a newly discovered long non-coding RNA (lncRNA), was aberrantly overexpressed in hepatic carcinoma, gastric and colorectal cancer. However, its effects on cervical has been kept unknown up to now. The present study aimed investigate the relationship between lncRNA CASC11 further explore mechanism of effect progression. Quantitative real-time polymerase chain reaction (RT-qPCR) used detect expressions cancerous adjacent...
The majority of current methods isolating circulating tumor cells (CTCs) rely on a biomarker. However, the isolation efficiency may be compromised due to heterogeneity CTCs. In this work, simple and broad-spectrum method is established efficiently isolate heterogeneous CTCs from patient blood samples using tannic acid (TA)-functionalized magnetic nanoparticles (MNPs). TA-functionalized MNPs (MNPs-TA) inhibit nonspecific adhesion peripheral mononuclear cell (PBMC) enhance cancer capture,...
The intramolecular ligand-to-metal charge transfer (LMCT) process acts as a fluorescence switch in MOF nanomaterials, effectively quenching or enabling fluorescence.
Long non-coding RNA HOTAIR has been revealed to participate in the tumorigenesis of various cancers. However, mechanism involvement cervical cancer not identified. Hence, this study aimed explore oncogenic and chemoresistant roles cancer, its underlying mechanism. RT-PCR, Western blot, Luciferase assay were employed determine relationship with miR-29b PTEN role cancer. CCK8 assay, cell migration, invasion used reveal proliferation metastasis. The inhibitory dose chemotherapeutics was...
Dual aptamer-modified PLGA nanofiber-based microfluidic devices were fabricated to achieve the highly efficient isolation and specific release of epithelial mesenchymal CTCs.
An accumulation of evidence has demonstrated that abnormal microRNA (miRNA or miR) expression is associated with different types cancer, including endometrial cancer (EC). The dysregulation miRNAs may serve important roles in the development and progression EC by regulating multiple aggressive biological behaviors, cell proliferation, apoptosis, metastasis angiogenesis. in‑depth understanding initiation be crucial for identifying successful therapeutic techniques. miR‑873 been to...
MicroRNAs (miRNAs/miRs) are small noncoding RNAs 19‑24 nucleotides in length, which can play an important role tumor development. However, the influence of miRNAs on tumorigenicity ovarian cancer cells has not been fully elucidated. Previously, DEAD box protein (DDX) 1 shown to a suppression progression. functions other DDX members development remain largely unknown. In present study, it was demonstrated that overexpression miR‑196a promoted cell proliferation. addition, DDX3 significantly...
Cervical cancer (CC) is the 4th most common cancer-related death in gynecological worldwide. It has been reported that many lncRNAs contribute to oncogenesis although fundamental mechanisms are basically unknown. Here, we aimed identify a novel lncRNA H1FX-AS1 and explore ceRNA network CC progression.The expression level association with prognosis of patients were analyzed based on Cancer Genome Atlas (TCGA) datasets, further verified 50 patients. The biological role was investigated vitro...
Abstract To screen the key circulating microRNAs (miRNAs) involved in missed abortion (MA) and explore their role MA process. We examined miRNA profile from serum of three patients early pregnancy induced (controls) by next‐generation sequencing. analyzed target genes differentially expressed (DE) miRNAs to analyze function pathway enrichment using Gene Ontology Kyoto Encyclopedia Genes Genomes, respectively. validated five candidate real time‐qPCR. Integrated miRNA‐mRNA‐pathway network...
Background: Emerging evidence indicates the importance of heparan sulfate 6-O-sulfotransferase 2 (HS6ST2) in a number developmental processes. Little is known regarding its biological function regulating cervical cancer (CC) progression. In this study, we aim to explore role HS6ST2 CC Methods: The transcriptome sequencing data tissues from three databases, GSE64217, GSE138080, and GSE63514, was examined for genes with significant changes. expression profile within tissue then assessed...
Objectives. To investigate the association of folic acid (FA) supplementation with hypertensive disorder complicating pregnancy (HDCP) and preeclampsia in Jiangsu Province, China. Materials Methods. In this cross-sectional study, a total 10,662 women infants born between January 2017 December 2018 were enrolled Maternal without FA supplement intake compared study. included 0.4 mg (0.4 FA), multivitamins (multivitamin (MV)+0.4 0.8 (MV + FA). Associations intake, dose or duration, FA) dosage...