A5074362502- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Pneumocystis jirovecii pneumonia detection and treatment
- Vasculitis and related conditions
- Lung Cancer Research Studies
- Airway Management and Intubation Techniques
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Pneumonia and Respiratory Infections
- Complement system in diseases
- Sepsis Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cell death mechanisms and regulation
- Ocular Diseases and Behçet’s Syndrome
- Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Blood Coagulation and Thrombosis Mechanisms
- Pleural and Pulmonary Diseases
- Streptococcal Infections and Treatments
- Neuroendocrine Tumor Research Advances
Miyazaki Prefectural Hospital
2015-2024
Fukuoka University Hospital
2024
Kawasaki Medical School
2024
Institute of Public Health Zadar
2020
University of Miyazaki
2020
Yazaki (United States)
2014
Kyushu University
2000-2007
University of Miyazaki Hospital
2005
Two veterinary personnel in Japan were infected with severe fever thrombocytopenia syndrome virus (SFTSV) while handling a sick cat. Whole-genome sequences of SFTSV isolated from the and cat 100% identical. These results identified nosocomial outbreak infection an animal hospital without tick as vector.
Next-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been developed to overcome resistance earlier generations of such drugs mediated by a secondary T790M mutation EGFR, but the performance second tumor biopsy assess status can be problematic.We and evaluated liquid assays for detection TKI-sensitizing mutations EGFR droplet digital PCR (ddPCR) in mutation-positive non-small cell lung cancer (NSCLC) patients with acquired EGFR-TKI resistance.A total...
Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) animal models. A multicenter non-randomized, uncontrolled single arm trial was conducted to collect data on the safety of favipiravir treatment patients. All participants received orally (first-day loading dose 1800 mg twice day followed by 800 for 7–14 days total). SFTSV RT-PCR biochemistry tests were performed at...
A Japanese man suffered from acute respiratory tract infection after returning to Japan Bali, Indonesia in 2007. Miyazaki-Bali/2007, a strain of the species Nelson Bay orthoreovirus, was isolated patient's throat swab using Vero cells, which syncytium formation observed. This is sixth report describing patient with caused by an orthoreovirus classified orthoreovirus. Given possibility that all patients were infected Malaysia and Indonesia, prospective surveillance on infections should be...
Guide sheaths (GSs) have been widely used during radial probe endobronchial ultrasound-guided transbronchial biopsy (rEBUS-TBB) of peripheral pulmonary lesions. However, it remains unknown whether a GS enhances the diagnostic yield. We compared yields small lesions between rEBUS-TBB with and without GS.In eight institutions, patients ≤30 mm in diameter were enrolled randomised to undergo (GS group) or (non-GS using 4.0-mm thin bronchoscope, virtual bronchoscopic navigation fluoroscopy. The...
Abstract Background and Objective The diagnostic yield of thin bronchoscopy with radial probe endobronchial ultrasound (rEBUS) peripheral pulmonary lesions into which the rEBUS cannot be inserted is unsatisfactory. In such cases, adding ultrathin may an option. We evaluated efficacy sequential for could not during bronchoscopy. Methods this multicentre prospective study, patients ≤30 mm in diameter underwent rEBUS‐guided transbronchial biopsy using a 4.0 bronchoscope. that bronchoscope, 3.0...
As opportunistic infections among human T-lymphotrophic virus type 1 (HTLV-1) carriers and patients with adult T-cell leukemia/lymphoma (ATL) pose a serious problem, it is necessary to clarify their clinical characteristics outcomes in these patients. We retrospectively analyzed the features of 127 HTLV-1 153 ATL between 2006 2016. The cumulative incidence rates were 1.5% (2/127) 6.5% (10/153), respectively. etiology was as follows: fungal (3 cases), pneumocystis pneumonia, cytomegalovirus...
This phase II trial evaluated the efficacy of erlotinib for patients with non-small cell lung cancer leptomeningeal metastasis. The 17 cerebrospinal fluid specimens that were available epidermal growth factor receptor mutation analysis all negative resistance-conferring T790M mutation. cytological objective clearance rate was 30.0% (95% confidence interval: 11.9%-54.3%). median time to progression 2.2 months. penetration among these equivalent those in previous reports regarding...
Objective The present study aimed to evaluate the clinical effectiveness of endoscopic bronchial occlusion (EBO) with endobronchial Watanabe spigots (EWSs) for management prolonged pulmonary air leaks, such as intractable pneumothorax, pyothorax fistula, and postoperative leakage.
Disseminated intravascular coagulation (DIC) is a clinical entity with high mortality and characterized by multiple organ failure caused activation of systemic coagulation. Although standard treatment for DIC has not been established owing to the absence randomized controlled trials, recent reports have indicated that recombinant human soluble thrombomodulin (rTM) effective against DIC. To elucidate characteristics outcomes DIC, we retrospectively analyzed 35 patients treated rTM at our...
Despite the remarkable advances in chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT), adult T-cell leukemia-lymphoma (ATL) is still associated with a high mortality rate. It therefore essential to elucidate current features of ATL.We retrospectively analyzed 81 patients aggressive type ATL at our institution over 7-year period based on Shimoyama's diagnostic criteria.Eighty-one median age 67.5 years were classified as having acute (n=47), lymphoma (n=32), or chronic...
Disseminated intravascular coagulation (DIC) is a clinical condition with high mortality that characterized by the systemic activation of pathways resulting in multiple organ failure. Although no standard treatment for DIC has been established, recent reports have indicated recombinant human soluble thrombomodulin (rTM) effective against DIC.To elucidate characteristics and outcomes DIC, we retrospectively analyzed 92 patients who were treated rTM at Miyazaki Prefectural Hospital over 4-year...
Objective Long-term steroid use increases the risk of developing Pneumocystis pneumonia (PcP), but there are limited reports on relation long-term and PcP mortality. Methods Retrospective multicenter study to identify factors for mortality, including average dose before first visit in non-human immunodeficiency virus (HIV)-PcP patients. We generated receiver operating characteristic (ROC) curves 90-day all-cause mortality mean daily per unit body weight preceding 10 90 days 10-day...
A 75-year-old man visited our hospital complaining of a low-grade fever, dry cough, and chest abnormal shadow. Chest computed tomography revealed nodule with cavity in the right upper lobe. Endobronchial ultrasonography (EBUS) lesion suggested that was benign. Actinomyces graevenitzii cultured from specimen obtained by bronchoscopy using endobronchial guide sheath technique identified matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 16S rRNA sequencing. The...
Early diagnosis is crucial for effective treatment of Wegener’s granulomatosis, although this disease shows only atypical symptoms in the primary stage. This report describes a patient suspected having malignancy based on integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), which showed increased uptake pulmonary nodules and nasopharyngeal mucosa. Integrated PET/CT therefore considered to be useful confirm distribution determine optimal site biopsy.
Objective Thrombotic thrombocytopenic purpura (TTP) is a life-threatening generalized disease with pathological features that are termed thrombotic microangiopathies. Since the discovery of von Willebrand factor-cleaving protease [a disintegrin and metalloproteinase thrombospondin type 1 motif, member 13 (ADAMTS13)], it widely known approximately two-thirds TTP patients have severe deficiency ADAMTS13 activity due to gene mutations or acquired autoantibodies this enzyme. However, remaining...