A5050845492- Viral Infections and Vectors
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Advanced Condensed Matter Physics
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- High-pressure geophysics and materials
- Magnetic and transport properties of perovskites and related materials
- Biofuel production and bioconversion
- Plant nutrient uptake and metabolism
- Fire effects on ecosystems
- Advanced Battery Technologies Research
- Plant tissue culture and regeneration
- Physics of Superconductivity and Magnetism
- Ubiquitin and proteasome pathways
- Pneumothorax, Barotrauma, Emphysema
- Pleural and Pulmonary Diseases
- Parasites and Host Interactions
- Streptococcal Infections and Treatments
- Radioactive element chemistry and processing
- Ferroelectric and Piezoelectric Materials
- Infective Endocarditis Diagnosis and Management
- Myasthenia Gravis and Thymoma
- Airway Management and Intubation Techniques
- X-ray Diffraction in Crystallography
Miyazaki Prefectural Hospital
2013-2024
Institute of Public Health Zadar
2020
University of Miyazaki
2009-2020
Ehime University
2014
Hokkaido University
2009-2011
Mie University
2001-2009
Japan Atomic Energy Agency
2009
Central Research Institute of Electric Power Industry
2005-2006
Japan Science and Technology Agency
2000-2004
Osaka Prefecture University
2003
WSX-1 is a member of the class I cytokine receptor family with homology to IL-12R beta 2 and essential for initial mounting Th1 responses. STAT1 interacts tyrosine-phosphorylated WSX-1, conserved tyrosine residue cytoplasmic domain transcriptional activation STAT1. IL-27 stimulation induced phosphorylation in wild-type but not WSX-1-deficient naive CD4(+) T cells. Although did directly induce IFN-gamma production by cells, IL-12-dependent was augmented cells impaired Additionally, T-bet...
This study provided the first evidence for an antioxidant action of silk protein sericin by showing that suppressed in vitro lipid peroxidation. Furthermore, was found to inhibit tyrosinase activity. These results suggest may be a valuable natural ingredient food and cosmetic industries.
Two veterinary personnel in Japan were infected with severe fever thrombocytopenia syndrome virus (SFTSV) while handling a sick cat. Whole-genome sequences of SFTSV isolated from the and cat 100% identical. These results identified nosocomial outbreak infection an animal hospital without tick as vector.
Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) animal models. A multicenter non-randomized, uncontrolled single arm trial was conducted to collect data on the safety of favipiravir treatment patients. All participants received orally (first-day loading dose 1800 mg twice day followed by 800 for 7–14 days total). SFTSV RT-PCR biochemistry tests were performed at...
The suppressor of cytokine signaling-3 (SOCS3/CIS-33/SSI-3) is an important negative regulator signaling. Here, we show that N-terminal truncated isoform (ΔN-SOCS3) translated from the internal AUG codon 12 was profoundly induced by endoplasmic reticulum (ER) stress- or active double-stranded RNA-activated protein kinase PKR, as a result induction eukaryotic initiation factor 2α phosphorylation. ΔN-SOCS3 exhibited stronger cytokine-inhibitory activity and higher stability than WT-SOCS3 in...
Abstract Administration of Con A induces liver injury that is considered to be an experimental model for human autoimmune or viral hepatitis, where immunopathology plays roles mediated by activated lymphocytes, especially NK1.1+ CD3+ NKT cells, and inflammatory cytokines, including IFN-γ IL-4. In the present study we investigated role WSX-1, a component IL-27R, in A-induced hepatitis taking advantage WSX-1 knockout mice. WSX-1-deficient mice were more susceptible treatment than wild-type...
A uniform coating on cathode materials for rechargeable lithium batteries was applied by a spray technique. The cells showed improved cycle performance and better durability of storing the cell (calendar life) under high-voltage charging condition (4.2 V-313 K). X-ray diffraction calorimetric study revealed that no marked change observed in bulk properties, such as crystal structure phase transition, during charge discharge. suppression increase cathode/electrolyte interfacial impedance...
A Japanese man suffered from acute respiratory tract infection after returning to Japan Bali, Indonesia in 2007. Miyazaki-Bali/2007, a strain of the species Nelson Bay orthoreovirus, was isolated patient's throat swab using Vero cells, which syncytium formation observed. This is sixth report describing patient with caused by an orthoreovirus classified orthoreovirus. Given possibility that all patients were infected Malaysia and Indonesia, prospective surveillance on infections should be...
Progression through mitosis requires the precisely timed ubiquitin-dependent degradation of specific substrates. E2-C is a ubiquitin-conjugating enzyme that plays critical role with anaphase-promoting complex/cyclosome (APC/C) in progression and exit from M phase. Here we report mammalian expressed late G 2 /M phase degraded as cells The shows an autoubiquitinating activity leading to covalent conjugation itself several ubiquitins. ubiquitination strongly enhanced by APC/C, resulting...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic in China, Korea, and Japan. To date, no standardized treatment protocol for SFTS has been established. Corticosteroids (CS) may be administered to patients hemophagocytic syndrome, but its effectiveness safety are still debatable. We conducted a retrospective case series review at four medical facilities Miyazaki, Based on the records, clinical data, including background, symptoms, physical findings,...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is the causative agent of SFTS, an emerging tick-borne disease in East Asia, and maintained enzootic cycles involving ticks a range wild animal hosts. Direct transmission SFTSV from cats dogs to humans has been identified Japan, suggesting that veterinarians veterinary nurses involved small-animal practice are at occupational risk infection. To characterize this risk, we performed sero-epidemiological survey small-animal-practice...
Objective The present study aimed to evaluate the clinical effectiveness of endoscopic bronchial occlusion (EBO) with endobronchial Watanabe spigots (EWSs) for management prolonged pulmonary air leaks, such as intractable pneumothorax, pyothorax fistula, and postoperative leakage.
Active transport systems for various amino acids operate in the vacuolar membrane of Saccharomyces cerevisiae. The gene families acid transporters were identified by reverse genetics experiments. In AVT transporter family, Avt1p works active uptake into vacuole, and Avt3p, Avt4p, Avt6p extrusion from vacuole to cytosol. Here, we found green fluorescent protein-tagged Avt7p, an unidentified member localized S. Disruption AVT7 enhanced both contents several activities glutamine proline...
We evaluated the stored body fat of Japanese black bears (Ursus thibetanus japonicus) killed as nuisances in Gifu and Fukushima prefectures, Japan, during 2005–2007. employed femur marrow (FMF), modified kidney index (mKFI), abdominal subcutaneous (ASF) indices for quantitative evaluation. examined basic characteristics these indices, such seasonality, age sex dependency, relationship among them. mKFI ASF increased towards beginning denning period (December), while FMF was relatively stable...