A5101775671- Hearing Loss and Rehabilitation
- Animal testing and alternatives
- Clinical Nutrition and Gastroenterology
- Neuroscience and Neural Engineering
- Neuroscience and Music Perception
- Photoreceptor and optogenetics research
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Invertebrate Immune Response Mechanisms
- EEG and Brain-Computer Interfaces
- Silk-based biomaterials and applications
- Muscle Physiology and Disorders
- Speech and Audio Processing
- Diet and metabolism studies
- Computational Drug Discovery Methods
- Neural dynamics and brain function
- Retinal and Macular Surgery
- Ubiquitin and proteasome pathways
- Muscle metabolism and nutrition
- Acoustic Wave Phenomena Research
- Liver physiology and pathology
- Protease and Inhibitor Mechanisms
- RNA and protein synthesis mechanisms
- Retinal Development and Disorders
- RNA Research and Splicing
Hayashibara (Japan)
2022
Toray Industries, Inc. (Japan)
2018
Wakayama University
2018
Sumitomo Chemical (Japan)
2008-2013
Toray (United States)
2011
Osaka University
1996-2010
Nara Institute of Science and Technology
2006-2008
Kyoto Institute of Technology
2001
Kansai Medical University
1966-2000
Aichi Medical University
1982
Growth of the posterior silk gland and biosynthesis fibroin during fifth larval instar silkworm, Bombyx mori, have been studied. In accordance with exponential increase in wet weight gland, amounts DNA, RNA, protein, lipids per animal increased rapidly early stage (0-96 hr). Biosynthesis fibroin, on contrary, mainly proceeds later (120-192 Electron microscopical observations shown that, very (0-12 hr), a number free ribosomes exist cytoplasm. Rough endoplasmic reticulum (ER) closely spaced...
1. A cell culture system of C2C12 myotubes was established as a model the muscle. With aid this model, half-lives intracellular proteins well activities and mRNA levels proteasomes (26S 20S) cathepsins (B, L, H) were examined in presence various amounts cytokines. 2. It found that 100 units/ml recombinant human interleukin-6 somewhat shortened half-life long-lived to 23.79 ± 1.55 h (control: 25.60 1.87 h). When 1% fetal bovine serum contained medium replaced by 0.5 mg/ml albumin, more...
Cytolytic processes in posterior silk gland cells of the silkworm, Bombyx mori, during metamorphosis from larva to pupa have been studied. During this stage, wet weight and amounts RNA protein decrease rapidly markedly, while amount DNA decreases slowly slightly. The ultrastructural changes observed at beginning prepupal stage consist appearance or increase number autophagosomes containing endoplasmic reticulum (ER), "early autophagosomes" as we called them, which seem be gradually...
We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis squamous-cell carcinoma, to determine whether susceptibility is associated these polymorphisms. There were no significant differences frequency distribution any one 3 between 132 healthy controls. The genotype distributions tobacco smokers or alcohol drinkers also quite similar for male age at onset was conclude that are unlikely be susceptibility.
The development of the cells in posterior silk gland silkworm, Bombyx mori, during fourth larval instar has been studied. In early stages this instar, wet weight and amounts RNA, DNA, protein per animal increase logarithmically until they reach a stationary state at about 72 hr. At around 96 hr larvae enter molting state, which lasts for 24 ecdysis. Towards end molt stage, growth is resumed. Electron microscopical observation shows that intermolt stage cytoplasm filled with free ribosomes...
Immune and inflammatory blood parameters have been reported as biomarkers for treatment efficacy. This study aimed to establish a predictive model that includes patients with metastatic breast cancer treated eribulin. A total of 297 were enrolled, their baseline neutrophil-to-lymphocyte ratio, absolute lymphocyte count (ALC), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), lymphocyte-to-monocyte (LMR), lactate dehydrogenase (LDH), C-reactive protein (CRP), clinical...
C2C12 myoblasts fuse to form multinucleated myotubes and express muscle specific proteins during differentiation. To elucidate developmental regulation of intracellular proteolytic systems, enzymatic activities, protein mRNA levels proteasomes (20S 26S) lysosomal cathepsins (B, L, H) were examined. Myoblasts differentiated fully 6 days after starting In this process, the 26S proteasome activity decreased, while 20S increased. Expression subunits (RC2, RC8) regulatory components (S4, S7) was...
Background: We have previously reported that the addition of nucleosides and a nucleotide mixture (OG‐VI) to total parenteral nutrition (TPN) prevents TPN‐induced intestinal mucosal atrophy results in increased cathepsin activities under TPN. The aims present study are examine effects OG‐VI on barrier functions clarify whether cathepsins can be used as new marker function. Method: Male Wistar rats were divided into three groups: FED (food ad libitum), TPN (a standard solution), OG (OG‐VI...
日常生活において, 複数人数での会話, 周囲に雑音がある中での会話, 電話での会話などで聞き取りが困難である場合, 難聴の自覚をもって耳鼻咽喉科を受診する. しかし聴覚検査で正常と診断される例では, 本人の聞こえの感じ方と検査結果に解離が見られ, 特にこのような聞こえの困難を自覚する例では聴覚情報処理障害が疑われる. しかし明確な診断基準がないためその診断には苦慮する. 今回そのような聞き取り困難例に対して聴覚心理・認知的検査の側面と背景要因の側面から検討を行った.
Objective: The temporal modulation transfer function (TMTF) has been proposed to estimate the resolution abilities of listeners with normal hearing and loss. TMTF data patients would be useful for clinical diagnosis adjusting instruments at fitting sites. However, practical application is precluded by long measurement time conventional method, which requires several points. This article presents a new method measure that only two Design: Experiments were performed loss demonstrate two-point...
Auditory temporal resolution plays a critical role in the everyday experience of listening to complex acoustic patterns. Amplitude modulation detection thresholds are widely used measure auditory resolution. In an attempt develop standardized clinical test resolution, we ZEST (Zippy Estimation by Sequential Testing, Bayesian threshold estimation procedure, amplitude thresholds. utilizes prior knowledge about listener's thresholds, as represented probability density function and psychometric...