A5062169419- Contact Dermatitis and Allergies
- Animal testing and alternatives
- Antimicrobial agents and applications
- Occupational exposure and asthma
- Pesticide Exposure and Toxicity
- Dental Health and Care Utilization
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Safe Handling of Antineoplastic Drugs
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Biotin and Related Studies
Lion Corporation (Japan)
2020-2022
Abstract The amino acid derivative reactivity assay (ADRA), which is an in chemico alternative to the use of animals testing for skin sensitization potential, offers significant advantages over direct peptide (DPRA) that it utilizes nucleophilic reagents are sensitive enough be used with test chemical solutions prepared concentrations 1 m , one‐hundredth DPRA. ADRA hydrophobic or other poorly soluble compounds requires they dissolved a solvent consisting dimethyl sulfoxide (DMSO) and...
This cross-sectional study performed to clarify the relationship between periodontal disease and non-communicable diseases (NCDs), such as obesity, diabetes mellitus, impaired glucose tolerance (IGT), chronic obstructive pulmonary (COPD), atherosclerotic cardiovascular (ASCVD) by introducing dental examinations into annual health conducted Japanese companies, highlights importance of a medical system that connects professionals.A total 1.022 Hitachi Ltd. employees were enrolled in this...
Amino acid derivative reactivity assay (ADRA) for skin sensitization was adopted as an alternative method in the 2019 OECD Guideline Testing of Chemicals (OECD TG 442C). The molar ratio nucleophilic reagent to test chemicals reaction solution set 1:50. Imamura et al. reported that changing this from 1:50 1:200 reduced false negatives and improved prediction accuracy. Hence, a ring study using ADRA with 4 mM chemical (ADRA, mM) conducted at five different laboratories verify within-...
The amino acid derivative reactivity assay (ADRA) is an in chemico alternative to animal testing that focuses on protein binding. ADRA a skin sensitization test solves problems associated with the direct peptide assay. However, when utilizing evaluate highly hydrophobic substances octanol/water partition coefficients (logKow) of >6, may not dissolve reaction solution, which can prevent accurate assessment sensitization. Therefore, we developed ADRA-organic solvent (ADRA-OS) system, novel...
The amino acid derivative reactivity assay (ADRA) is an in chemico alternative for skin sensitization listed OECD test guideline 442C. ADRA evaluates the of sensitizers to proteins, which key event 1 adverse outcome pathway. Although current evaluation method a simple that nucleophile and chemical reactivity, mixtures unknown molecular weights cannot be evaluated because constant molar ratio between necessary. In addition, quantified by HPLC, frequency co-eluting increases when measuring...