A5070187001- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Musculoskeletal synovial abnormalities and treatments
- Bone fractures and treatments
- Viral gastroenteritis research and epidemiology
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Traffic and Road Safety
- Hepatitis Viruses Studies and Epidemiology
- Shoulder Injury and Treatment
- Complement system in diseases
- Elbow and Forearm Trauma Treatment
- Immune Cell Function and Interaction
- Urban Transport and Accessibility
- Injury Epidemiology and Prevention
University of Colorado Denver
2024-2025
Duke Medical Center
2022-2024
Duke University
2022-2024
University of Colorado Anschutz Medical Campus
2024
Yahoo (United Kingdom)
2024
Background: Trigger finger (TF) causes pain and functional impairment. Previous studies have associated TF with carpal tunnel syndrome, which has been linked to obesity. This study investigated the relationship between obesity prevalence of TF. Methods: A retrospective analysis was conducted using data from TriNetX Research Network (2006-2024). Patients risk factors for (rheumatoid arthritis, gout, amyloidosis, prior release, spontaneous rupture flexor tendons, hypothyroidism, Dupuytren...
Low back pain (LBP) is a leading global factor in disability among older adults. Movement-evoked (MEP) potentially an important mediator the pathway but predominantly tested laboratory. We aimed to explore MEP natural environment ("daily" MEP) and its correlation with laboratory MEP, along potential psychological immunological influences. Thirty-five adults persistent LBP attended single session. Pain catastrophizing, pain-related fear of movement, self-efficacy were measured by...
Background. Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the grafts. Despite this, there little consensus on optimal conditions. Hypothermic offers limited functional assessment, whereas normothermic requires a more complex mechanical system perfusate. Subnormothermic machine (SNMP) has potential to combine advantages of both approaches but undergone investigation. Therefore, present study sought determine suitability SNMP for...
Background. Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis allograft rejection. Improved preservation may expand transplantable numbers enhance posttransplant outcomes. Superior transplant outcomes have recently been demonstrated in clinical trials using machine perfusion preserve the liver. We hypothesized of allografts could be achieved allow for a porcine model. Methods....
Subnormothermic machine perfusion (SNMP) of liver grafts is currently less clinically developed than normothermic and hypothermic approaches, but may have logistical advantages. At intermediate temperatures, the oxygen demand graft low enough to be satisfied with an acellular perfusate, obviating need for carrying molecules. This metabolic rate, however, sufficient support production bile, which emerging as important indicator injury viability. In this study, we hypothesized that biliary...
Advances in surgical technique and multidisciplinary management have improved long-term survival for patients born with single ventricle physiology. However, who undergone Fontan completion remain at risk comorbidities associated the complex hemodynamic changes following procedure, including failure Fontan-associated liver disease.1 Combined heart-liver transplantation (CHLT) is a rare but lifesaving procedure that has been described setting of heart secondary to failure.2 As continues...
Background. The clinical success of liver transplantation has led to increased demand, requiring further expansion the donor pool. Therapeutic interventions optimize organs from donation after circulatory death (DCD) have significant potential mitigate organ shortage. Dysfunction in DCD grafts is mediated by microvascular thrombosis during warm ischemic period, and strategies that reduce this thrombotic burden may improve graft function. We hypothesized administration fibrinolytic enzyme...
Electric scooters (e-scooters) have become a widely adopted form of transportation. Information regarding the timing, conditions, and context associated with increased frequency e-scooter-related injuries could inform policy that may potentially reduce healthcare costs. However, this information is lacking, as most research to date has focused on injury patterns sustained while using e-scooters rather than context. We sought evaluate these factors in an urban setting describe how are...
ABSTRACT Background Natural killer (NK) cells have gained recognition for playing an integral role in both alloimmunity and protective immunity, particularly viral infection control, solid organ transplantation. Using data from the Clinical Trials Organ Transplantation Children (CTOTC) study entitled, “Immune Development Pediatric Transplantation,” (NCT00951353), we aimed to identify NK cell phenotypes that were associated with versus alloreactive events during first year after We also...
Normothermic machine perfusion (NMP) facilitates utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison outcomes and hospitalization for donor livers preserved by NMP versus static cold storage (SCS) at high-volume center. Adult patients receiving deceased transplants either (TransMedics Organ Care System) or SCS between January 1, 2021—December 31, 2023 were included. Donor recipient...
Introduction Recombinant adeno-associated virus (rAAV) is a novel strategy used clinically for gene delivery, but has not been characterized in the context of organ transplantation. We sought to determine efficacy rAAV-mediated delivery during static cold storage (SCS) prior liver Methods A triple-plasmid transfection protocol was produce rAAV subtype-9 vectors containing firefly luciferase genomes HEK293 cells. Lewis rat grafts were flushed and stored HTK solution. Three experimental groups...
Background: A limitation of intestinal transplantation is severe graft injury during cold storage, leadng to sepsis and rejection. Improved preservation will improve post-transplant outcomes. Recently, trials oxygenated machine perfusion (MP) in liver show superior outcomes compared storage. We hypothesized MP grafts would be feasible after intestine transplantation, similar other transplanted organs. The aim this study was develop a translational normothermic (NMP) protocol full-length...