A5016667109- Orthopedic Surgery and Rehabilitation
- Burn Injury Management and Outcomes
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Elbow and Forearm Trauma Treatment
- Wound Healing and Treatments
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Trauma Management and Diagnosis
- Trauma and Emergency Care Studies
- Peripheral Nerve Disorders
- Pressure Ulcer Prevention and Management
- Anesthesia and Neurotoxicity Research
- Shoulder Injury and Treatment
- Vagus Nerve Stimulation Research
- Nerve Injury and Rehabilitation
- Organ and Tissue Transplantation Research
- Surgical Sutures and Adhesives
- Intensive Care Unit Cognitive Disorders
- Muscle and Compartmental Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Body Image and Dysmorphia Studies
Denver Health Medical Center
2013-2024
University of Colorado Denver
2013-2024
University of Colorado Anschutz Medical Campus
2023-2024
Estée Lauder (United States)
2021
TriHealth
2021
Connecticut Children's Medical Center
2018
Rutgers New Jersey Medical School
2018
Rutgers, The State University of New Jersey
2018
Colorado School of Public Health
2011
University of Colorado Health
2010
Background: Beta-adrenoreceptor blocker (β-blocker) therapy may improve outcomes in surgical patients by decreasing cardiac oxygen consumption and hypermetabolism. Because β-blockers can lower the systemic blood pressure cerebral perfusion pressure, there is concern regarding their use with head injury. However, protect β-receptor rich brain cells attenuating metabolism. We hypothesized that are safe trauma patients, even if they have suffered a significant Methods: Using pharmacy registry...
Although acute lung injury (ALI) is an important problem in humans, its pathogenesis poorly understood. Airway instillation of bacterial LPS, a known complement activator, represents frequently used model ALI. In the present study, pathways immunopathogenesis ALI were evaluated. was induced wild-type, C3(-/-), and C5(-/-) mice by airway deposition LPS. To assess relevant inflammatory mediators, bronchoalveolar lavage fluids evaluated ELISA analyses various neutralizing Abs receptor...
Defective cardiac function during sepsis has been referred to as “cardiomyopathy of sepsis.” It is known that leads intensive activation the complement system. In current study, and cardiomyocyte contractility have evaluated in rats after cecal ligation puncture (CLP). Significant reductions left ventricular pressures occurred vivo vitro. These defects were prevented CLP given blocking antibody C5a. Both mRNA protein for C5a receptor (C5aR) constitutively expressed on cardiomyocytes; both...
Abstract Introduction Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is known complication sepsis. However, its pathophysiology remains unclear. The present study investigated effect complement C5a blockade in preventing BBB damage and pituitary dysfunction during experimental Methods Using standardised caecal ligation puncture (CLP) model, Sprague-Dawley rats were treated with either neutralising anti-C5a antibody or pre-immune immunoglobulin (Ig) G as...
Abstract The relationship between local inflammation and the subsequent systemic inflammatory response is poorly described. In a burn injury model, dermal may act as an ongoing trigger for syndrome (SIRS) complications. We hypothesized that topical attenuation of wound signaling will control source, attenuate SIRS, reduce acute lung injury. Mice received 30% total body surface area burn. Subgroups were treated with specific p38 MAPK inhibitor or vehicle, which was topically applied to...
Thermal injury induces dermal inflammatory and proapoptotic signaling. These phenomena extend burn wound size trigger a systemic response, factors known to adversely affect outcomes. p38MAPK is responses induce epithelial genes. We hypothesize that topical inhibition will attenuate excessive apoptotic signaling reduce tissue loss. Rats were given 30% total body surface area partial thickness or sham injury. Some of the animals treated with inhibitor vehicle, which was applied directly wound....
Abstract We previously reported that generation of the anaphylatoxin C5a is linked to development cardiac dysfunction in sepsis due interaction with its receptor (C5aR) on cardiomyocytes. Burn injury involves inflammatory mechanisms can lead as well. In this study, we investigated effects blockade burn-induced dysfunction. Using a standardized rat model full thickness scald injury, left ventricular pressures were recorded vivo followed by vitro assessment sarcomere contraction single Left...
A component of multiorgan dysfunction in burned patients is heart failure. Burn trauma induces cytokine synthesis interleukin (IL) 1β, IL-6, and tumor necrosis factor α (TNF-α) which can negatively impact cardiac function. Infectious complications are common following severe burn injury. We hypothesized that injury lipopolysaccharide (LPS) exposure independently influence peak cardiomyocyte contraction secretion. Rats underwent a full-thickness 30% total body surface area scald or sham burn....
Low energy trauma to the upper extremity is rarely associated with a significant vascular injury. Due low incidence, high level of suspicion combined appropriate diagnostic algorithms are mandatory for early recognition and timely management these potentially detrimental injuries.Review pertinent literature, supported by presentation two representative "near miss" case examples.A major pitfall represented insidious arterial injuries intact pulses normal capillary refill distal injury site,...
Abstract Background Sepsis continues to be a poorly understood syndrome with high mortality rate. While we are beginning decipher the intricate interplay of inflammatory response during sepsis, precise regulation hypothalamic-pituitary-adrenal (HPA) axis and its impact on electrolyte homeostasis sepsis remains incompletely understood. Methods was induced in adult male Sprague-Dawley rats by cecal ligation puncture (CLP). Plasma samples were obtained as function time (6-48 hrs) after CLP...
Background: To advance occupant protection through the improvement of safety countermeasures, it is necessary to understand factors that affect human injury tolerance. This study investigated effect ‘occupant factors' i.e. age, gender, height, weight, and body mass index (BMI) on pattern lower extremity after motor vehicle crashes (MVCs). The second objective was identify factor(s) (including restraint systems Δ V) influence severity fractures (open versus close fractures) within area....
Objective: We previously showed that topical inhibition of inflammatory signaling in burn wounds reduced systemic response and burn-induced pulmonary inflammation. hypothesized this intervention would attenuate lung injury, improve function, protect lungs from bacterial invasion, reduce mortality. Design: Controlled, vivo, laboratory study. Setting: University laboratory. Subjects: Female mice, 8–10 wks old. Interventions: Animals received 30% total body surface area followed by application...
Since its introduction more than 30 years ago, wrist arthroscopy has become an essential diagnostic and therapeutic tool in hand surgery. This procedure minimizes exposures allows access to otherwise remotely located anatomic regions with minimal morbidity. Advances understanding scope technology have standardized the expanded indications. Current applications are staging of various pathologies where for a direct, magnified, tactile-assisted examination. includes injuries triangular...