A5020028265- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Viral Infections and Immunology Research
- Organ and Tissue Transplantation Research
- Clinical Nutrition and Gastroenterology
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Luminescence Properties of Advanced Materials
- Enhanced Recovery After Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral gastroenteritis research and epidemiology
- Diabetes Management and Research
- Nanoplatforms for cancer theranostics
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Multiple and Secondary Primary Cancers
- Pregnancy and Medication Impact
- Pluripotent Stem Cells Research
Duke Medical Center
2018-2023
Duke University Hospital
2020-2022
Duke University
2020-2022
University of Massachusetts Chan Medical School
2013-2020
Dartmouth–Hitchcock Medical Center
2016-2017
Dartmouth College
2015-2017
Upconversion nanoparticles (UCNPs) can convert tissue-penetrable nearinfrared light into UV emission, making them promising as transducers for photoactivation in biology. However, the choice of emitting UCNPs is limited and their NIR-to-UV efficiency low. G. Han co-workers have addressed this issue by developing a family CaF2-coated with tunable enhancement. As reported on page 3213, such design outperforms known optimal situ realtime live-cell recorded first time nanoparticles. This result...
A family of upconverting nanoparticles (UCNPs) with a tunable UV enhancement is developed via facile approach. The design leads to maximum 9-fold in comparison known optimal β-phase core/shell UCNPs water. highly effective and rapid situ real-time live-cell photoactivation recorded for the first time such nanoparticles.
Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of kidney waiting list. A 2017 change policy delineated renal function criteria and implemented a safety net kidney-after-liver transplantation. We compared use outcomes transplant policy. Network Organ Sharing Standard Transplant Analysis Research files used to identify adults who received liver transplantations (LT)...
OBJECTIVES: Total pancreatectomy with islet autotransplantation (TPIAT) is increasingly performed remote cell processing and preparation, i.e., isolation remotely from the primary surgical site at an appropriately equipped facility. We aimed to determine whether TPIAT using results in comparable long-term glycemic outcomes compared standard local isolation. METHODS: a retrospective cohort study of adult patients who underwent three tertiary care centers 2010 2013. Two one Explanted pancreata...
Ex vivo lung perfusion (EVLP) is a novel preservation strategy that facilitates the use of marginal allografts; however, it more expensive than static cold storage (SCS). To understand how method might affect postoperative costs, we compared outcomes and index hospitalization costs among matched EVLP SCS preserved transplant (LTx) recipients at single, high-volume institution. A total 22 66 LTx were included; grafts further stratified as either standard-criteria (SCD) or extended-criteria...
Background: Outcomes after kidney transplantation (KTx) remain limited by delayed graft function (DGF) and acute rejection. Non-invasive biomarkers may help identify patients at increased risk for these events. We examined the association between systemic immune-inflammation index (SII), a novel inflammatory biomarker, outcomes KTx evaluated its ability to predict post-transplant prognosis. Patients Methods: Adult who underwent primary our institution 2016-2019 were included. SII was...
Objectives Total pancreatectomy with islet autotransplantation is increasingly being performed remotely, that is, removing the pancreas in 1 location, isolating cells another then returning islets to original location for reimplantation into patient. We determined influence of extended cold ischemia time on key clinical outcomes remote autotransplantation. Methods evaluated patients who underwent at 2 centers from 2011 2014. Patients were divided groups: those and without a decrease...
Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point-of-care (POC) biomarkers predict risk guide decision making are lacking. In this investigation, we characterized trends in POC during NMP compared primate donation after circulatory death (DCD) with short prolonged warm ischemic injury. Following asystole, were subjected either 5 minutes (DCD-5min, n = 4) or 45 (DCD-45min, of ischemia...
Selection of the optimal treatment modality for primary liver cancers remains complex, balancing patient condition, function, and extent disease. In individuals with preserved resection approach curative intent but may be associated significant mortality. The purpose this study was to establish a simple scoring system based on Model End-stage Liver Disease (MELD) guide risk assessment resections.The 2005-2015 NSQIP database queried patients undergoing malignancy. We first developed model...
Objective: We sought to compare kidney transplantation outcomes between Veterans Affairs (VA) and non-VA transplant centers. Summary Background Data: Transplant care at the VA has previously been scrutinized due geographic systematic barriers. The recently instituted MISSION Act entered effect June 6 th , 2019, which enables veteran access surgical civilian hospitals if certain eligibility criteria are met. Methods: evaluated observed-to-expected outcome ratios (O:E) for graft loss mortality...
Subnormothermic machine perfusion (SNMP) of liver grafts is currently less clinically developed than normothermic and hypothermic approaches, but may have logistical advantages. At intermediate temperatures, the oxygen demand graft low enough to be satisfied with an acellular perfusate, obviating need for carrying molecules. This metabolic rate, however, sufficient support production bile, which emerging as important indicator injury viability. In this study, we hypothesized that biliary...
Abstract The cellular mechanisms underlying impaired function of aged liver grafts have not been fully elucidated, but mitochondrial dysfunction appears to be contributory. Sirtuin1 has identified as a key mediator recovery following ischemia–reperfusion injury. purpose this study was determine whether differences exist in sirtuin-1 expression/activity old vs. young and correlations with function, graft metabolic Old rat (N = 7 per group) were exposed 12 h static cold storage (SCS), followed...
Abstract Light‐controlled sequential photolysis from a single nanoparticle is challenge for controlled release. A wavelength‐selective gold nanoparticles reported the first time. In particular, it also demonstrated that such can be used to sequentially release two payloads in living cells. principle, this system extended of multiple different types by rational design diverse photocleavable linkers. It expected work provide new tool better orderly controlling cellular events request high...
The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree associated superior survival. Additionally, living donor grafts are known to confer compared those from deceased donors. purpose this study is report our multi-decade institutional experience and outcomes for patients who received HLA-identical grafts, which represent the most favorable scenario kidney transplantation. We conducted retrospective analysis these recipients...