A5084192056- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- HIV Research and Treatment
- Photoreceptor and optogenetics research
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- RNA regulation and disease
- Pharmacological Receptor Mechanisms and Effects
- Aging and Gerontology Research
Rutgers, The State University of New Jersey
2020-2024
University of Pennsylvania
2013-2023
Johnson University
2021-2023
Rutgers Sexual and Reproductive Health and Rights
2020
Boston University
1999-2009
California University of Pennsylvania
2008
San Francisco AIDS Foundation
2005
University of California, San Francisco
1978-2005
University of Washington
1966-1999
Washington State University
1995-1997
One of the major determinants reinstatement to cocaine use among human addicts is acute reexposure drug, which often precipitates craving and relapse. We used an animal model relapse determine role glutamatergic pathway from medial prefrontal cortex (mPFC) nucleus accumbens in cocaine-seeking behavior after a priming injection. Rats were trained self-administer intravenously on second order schedule. Responding was extinguished subsequently by substituting saline for cocaine. During...
Serotonin (5-HT) modulates neural responses to socioaffective cues and can bias approach or avoidance behavioral decisions, yet the cellular mechanisms underlying its contribution regulation of social experiences remain poorly understood. We hypothesized that GABAergic neurons in dorsal raphe nucleus (DRN) may participate by controlling serotonergic tone during interaction. tested this hypothesis using whole-cell recording techniques genetically identified DRN GABA 5-HT mice exposed defeat,...
Increasing evidence suggests that deep brain stimulation (DBS), which is currently being used as a therapy for neurological diseases, may be effective in the treatment of psychiatric disorders well. Here, we examined influence DBS nucleus accumbens shell on cocaine priming-induced reinstatement drug seeking, an animal model relapse. Rats were allowed to self-administer (0.25 mg, i.v.) 2 h daily 21 d and then cocaine-seeking behavior was extinguished by replacing with saline. During phase,...
HIV-associated neurocognitive disorder (HAND), characterized by a wide spectrum of behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50 % HIV(+) patients despite the success combination antiretroviral drug therapy (cART) in periphery. Of note, potential toxicity drugs central nervous system (CNS) remains remarkably underexplored may contribute persistence HAND cART era. Previous studies have shown antiretrovirals (ARVs) be neurotoxic peripheral vivo neurons...
Cocaine self-administration alters patterns of gene expression in the brain that may underlie cocaine-induced neuronal plasticity. In present study, male Sprague Dawley rats were allowed to self-administer cocaine (0.25 mg/infusion) 2 h/d for 14 d, followed by 7 d forced abstinence. Compared with yoked saline control rats, resulted increased brain-derived neurotrophic factor (BDNF) protein levels rat medial prefrontal cortex (mPFC). To examine functional relevance this finding, maintained...
Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for control of palatable food intake. Here, we tested whether intake-suppressive effects VTA GLP-1R are mediated by glutamatergic signaling within VTA. Intra-VTA injections agonist exendin-4 (Ex-4) reduced high-fat intake rats primarily reducing meal size; these were part via AMPA/kainate but not NMDA signaling. Additional behavioral data indicated that expressed specifically...
Accumbal deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of addiction. Here, we demonstrate that DBS in nucleus accumbens shell, but not core, attenuates cocaine priming-induced reinstatement drug seeking, an animal model relapse, male Sprague Dawley rats. Next, compared shell with pharmacological inactivation. Results indicated inactivation using reagents influenced (lidocaine) or spared (GABA receptor agonists) fibers passage blocked when administered...
Glucagon-like peptide-1 receptor (GLP-1R) activation in the nucleus accumbens (NAc) core is pharmacologically and physiologically relevant for regulating palatable food intake. Here, we assess whether GLP-1R signaling NAc of rats modulates GABAergic medium spiny neurons (MSNs) through presynaptic-glutamatergic and/or presynaptic-dopaminergic to control feeding. First, ex vivo fast-scan cyclic voltammetry showed that agonist exendin-4 (Ex-4) does not alter dopamine release core. Instead,...
Abstract Endogenous homeostatic mechanisms can restore normal neuronal function following cocaine-induced neuroadaptations. Such may be exploited to develop novel therapies for cocaine addiction, but a molecular target has not yet been identified. Here we profiled mouse gene expression during early and late abstinence identify putative regulators of neural homeostasis. Cocaine activated the transcription factor, Nr4a1 , its gene, Cartpt key molecule involved in dopamine metabolism. Sustained...
These experiments were designed to assess the role of neurotrophins and Ras/mitogen-activated protein kinase (MAP) signal transduction cascade in behavioral sensitization cocaine. The first evaluated effect three daily intra-ventral tegmental area (VTA) microinjections neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF) on behavioral-activating effects a subsequent challenge injection cocaine rats. Results indicated that, although NT-3 did not influence behavior across...