A5090439739- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Phosphodiesterase function and regulation
- Health, Environment, Cognitive Aging
- Cell Image Analysis Techniques
- Neuropeptides and Animal Physiology
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Regulation of Appetite and Obesity
- Amino Acid Enzymes and Metabolism
Blackfynn (United States)
2021
University of Pennsylvania
2011-2020
Accumbal deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of addiction. Here, we demonstrate that DBS in nucleus accumbens shell, but not core, attenuates cocaine priming-induced reinstatement drug seeking, an animal model relapse, male Sprague Dawley rats. Next, compared shell with pharmacological inactivation. Results indicated inactivation using reagents influenced (lidocaine) or spared (GABA receptor agonists) fibers passage blocked when administered...
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase (PKA) to enable localized signaling events within neurons. However, it is unclear which the many expressed AKAPs in neurons target PKA complexes important for long-lasting forms synaptic plasticity and memory storage. In forebrain, anchoring gravin recruits a complex containing PKA, PKC, calmodulin, PDE4D (phosphodiesterase 4D) β2-adrenergic receptor. Here, we show that mice lacking α-isoform have deficits...
Alterations in cAMP signaling are thought to contribute neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role determining spatial degradation so as orchestrate compartmentalized cells. Each isoform binds set protein complexes through its unique N-terminal domain, thereby leading targeted specific intracellular compartments. However, functional PDE4 isoforms has not been examined...
The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds provide...
The ability of neurons to differentially respond specific temporal and spatial input patterns underlies information storage in neural circuits. One means achieving specificity is restrict signaling molecules particular subcellular compartments using anchoring such as A-Kinase Anchoring Proteins (AKAPs). Disruption protein kinase A (PKA) AKAPs impairs a PKA-dependent form long term potentiation (LTP) the hippocampus. To investigate role localized PKA LTP, we developed stochastic...
Recent studies indicate a critical role for metabotropic glutamate receptor 5 (mGluR5) in the reinstatement of cocaine seeking. However, signal transduction pathways through which mGluR5s regulate seeking have not been identified. Here, we show that intra-accumbens shell administration an mGluR5 (9.0 μm MPEP), but mGluR1 (50.0 YM 298198), antagonist before priming injection (10 mg/kg) attenuated drug rats. Consistent with these results, intra-shell microinjection mGluR1/5 agonist DHPG (250...
ABSTRACT The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds...