A5008763930- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Memory and Neural Mechanisms
- Retinal Development and Disorders
- stochastic dynamics and bifurcation
- Cutaneous lymphoproliferative disorders research
- Olfactory and Sensory Function Studies
- Computational Drug Discovery Methods
- Education and Digital Technologies
- T-cell and Retrovirus Studies
- Semiconductor Quantum Structures and Devices
- S100 Proteins and Annexins
- Circadian rhythm and melatonin
- Phosphodiesterase function and regulation
- Fungal Infections and Studies
- Semiconductor materials and interfaces
- Neuroscience and Neural Engineering
- Neural Networks and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Health Systems, Economic Evaluations, Quality of Life
- Motor Control and Adaptation
Universidade do Estado do Rio Grande do Norte
2020-2024
Universidade Federal do Rio de Janeiro
2021
Fundo Brasil
2021
Champalimaud Foundation
2015-2020
George Mason University
2007-2013
Complexo Hospitalar Universitário Professor Edgard Santos
2013
Universidade Federal da Bahia
2010-2013
Institute for Advanced Study
2008-2013
Centro Universitário do Pará
2010
Universidade de São Paulo
1999-2008
Behavioral control is not unitary. It comprises parallel systems, model based and free, that respectively generate flexible habitual behaviors. Model-based decisions use predictions of the specific consequences actions, but how these are implemented in brain poorly understood. We used calcium imaging optogenetics a sequential decision task for mice to show anterior cingulate cortex (ACC) predicts state actions will lead to, simply whether they good or bad, monitors outcomes match...
Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which diffuses. Two mechanisms have been proposed to produce elevations cAMP, known as microdomains: impeded diffusion, high phosphodiesterase (PDE) activity. This paper investigates mechanism signaling using computational model biochemical...
Learning to perform a complex motor task requires the optimization of specific behavioral features cope with constraints. We show that when mice learn novel paradigm they differentially refine features. Animals trained progressively faster sequences lever presses obtain reinforcement reduced variability in sequence frequency, but increased an orthogonal feature (sequence duration). Trial-to-trial activity cortex and striatal projection neurons was higher early training subsequently decreased...
Dopamine release in the striatum has been implicated various forms of reward dependent learning. leads to production cAMP and activation protein kinase A (PKA), which are involved striatal synaptic plasticity PKA its targets not diffusely located throughout neuron, but confined subcellular compartments by anchoring molecules such as A-Kinase Anchoring Proteins (AKAPs). Experiments have shown that blocking interaction with AKAPs disrupts location prevents LTP hippocampus striatum; however,...
Sensory arrays made of coupled excitable elements can improve both their input sensitivity and dynamic range due to collective nonlinear wave properties. This mechanism is studied in a neural network electrically (e.g., via gap junctions) subject Poisson signal process. The response interpolates between Weber-Fechner logarithmic law, Stevens power law depending on the relative refractory period cell. Therefore, these transformations level could be performed sensory periphery simply basic...
The ability of neurons to differentially respond specific temporal and spatial input patterns underlies information storage in neural circuits. One means achieving specificity is restrict signaling molecules particular subcellular compartments using anchoring such as A-Kinase Anchoring Proteins (AKAPs). Disruption protein kinase A (PKA) AKAPs impairs a PKA-dependent form long term potentiation (LTP) the hippocampus. To investigate role localized PKA LTP, we developed stochastic...
The neural mechanisms that support the late postnatal development of spatial navigation are currently unknown. We investigated this in rats and found an increase duration AMPAR-mediated synaptic responses hippocampus was related to emergence navigation. More specifically, spontaneous alternation rate, a behavioral indicator hippocampal integrity, increased at end third week association with increases AMPAR response SC-CA1 synapses synaptically driven postsynaptic discharge CA1 pyramidal...
Recent works suggest that one of the roles gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation first processing stages. In this work, we use a minimal conductance-based model ON rod pathways vertebrate retina study effects electrical synaptic coupling via among rods and AII amacrine cells on retina. The also used maximum conductance hyperpolarization activated current I(h) retina, allowing interrelations between intrinsic membrane parameter with...
Summary The anterior cingulate cortex (ACC) is implicated in learning the value of actions, but it remains poorly understood whether and how contributes to model-based mechanisms that use action-state predictions afford behavioural flexibility. To isolate these mechanisms, we developed a multi-step decision task for mice which both transition probabilities reward changed over time. Calcium imaging revealed ramps choice-selective neuronal activity, followed by an evolving representation state...
Abstract Objectives: To evaluate the frequency of different types cutaneous lymphoma (CL) in 1 university hospital Brazil and compare this with those observed other countries. Methods: After review, 72 (84.7%) cases primary T-cell (CTCL) 13 (15.3%) B-cell (CBCL) were included. Results: Of CTCLs, 40.3% mycosis fungoides (MF); 26.4% adult leukemias/lymphomas (ATLs); 23.6% peripheral lymphomas, unspecified; 8.3% anaplastic large cell lymphomas. MF cases, 17.2% progressed to transformed MF....
Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting calcium levels dendrites[1-3]. Increased trigger changes plasticity[4,5], which is important for learning and other functions[6]. Studies hippocampus shown that GABAergic input can modulate backpropagation from soma distal dendrites[7]. The MS neurons receive both proximal feedforward inhibition fast spiking interneurons (FS), feedback neighbouring...
Buscou-se relatar uma experiência de estágio curricular em Psicologia, no qual foram discutidos os novos contextos e demandas que surgem para a neste momento se encontra o processo globalização as influências neo-liberais. A inserção dos estagiários numa perspectiva multidisciplinar com profissionais saúde foi concretizada partir do desenvolvimento grupos adolescentes um centro bairro baixa-renda. Foram acompanhados três grupos, semanalmente, durante semestre letivo, por dois Psicologia....
Brain benefits from physical exercise associated with antioxidant supplements such as flaxseed oil. This low cost and simple association may improve hippocampal plasticity, which work a preventive effective therapy in neuroprotection neuroplasticity processes. evaluated the effects of oil supplementation (Linum usitatissimum L.) hippocampus Wistar rats. We separated male rats into four experimental groups: control group (sedentary), sedentary supplemental diet oil, under program...