A5054182608- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Spaceflight effects on biology
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Phytochemistry Medicinal Plant Applications
- Adipose Tissue and Metabolism
- Neurological disorders and treatments
- Bat Biology and Ecology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
Universidade Federal do Rio Grande do Norte
2016-2025
Istituto S.Anna Crotone
2021
Escola da Cidade
2021
Universidade de São Paulo
2002
Abstract Non‐image forming (NIF) pathways, a specialized branch of retinal circuitry, play crucial role supporting physiological and behavioral processes, including circadian rhythmicity. Among the NIF regions, dorsal raphe nucleus (DRN), midbrain serotonergic cluster neurons, is also devoted to functions. Despite indirectly send photic inputs centers modulating their activities, little known about organization retina‐DRN circuits in primate species. To enhance our understanding intrinsic...
The medial pulvinar thalamic nucleus (MPu) is an evolutionary novelty of the primate thalamus, prominently expanded in humans. Piecemeal data from studies various monkey species indicates that MPu axons reach prefrontal, inferior parietal, cingulate, insular or temporal areas; however, precise wiring and functional logic such brain-wide connections remain obscure. In marmoset monkeys (Callithrix jacchus) both sexes, we visualized originated specific domains by means biotinylated dextranamine...
The striatum (St) integrates cognitive, motor, and limbic functions plays a critical role in processing emotions, motivation, rewards. It may undergo several morphophysiological changes neuropsychiatric diseases. Depression, complex psychiatric disorder, affects millions of people around the world leads to an increased risk suicide, decreased quality life, functional impairment. Conventional treatments require prolonged use, leading drug resistance; thus, new therapeutic strategies have been...
<title>Abstract</title> Depression remains a debilitating mental health disorder affecting millions worldwide, with growing prevalence among adolescents. Recent studies highlight the critical role of somatosensory cortex in neuropathology depression, including structural alterations that impair cortical function. This study investigates prophylactic effects ayahuasca, traditional psychoactive brew, on morphological changes induced by chronic stress juvenile non-human primates. Using model...
The PER3 gene is one of the clock genes, which function in core mammalian molecular circadian system. A variable number tandem repeats (VNTR) locus 18th exon this has been strongly associated to rhythm phenotypes and sleep organization humans, but it not identified other mammals except primates. To better understand evolution placement VNTR a phylogenetical context, present study enlarges investigation about presence structure region large sample primate species mammals. analysis results...
All mammal behaviors and functions exhibit synchronization with environmental rhythms.This is accomplished through an internal mechanism that generates modulates biological rhythms.The circadian timing system, responsible for this process, formed by connected neural structures.Pathways receive transmit cues to the central oscillator, hypothalamic suprachiasmatic nucleus, which mediates physiological behavioral alterations.The nucleus has three major inputs: retinohypothalamic tract (a direct...
Reserpine is an irreversible inhibitor of VMAT2 used to study Parkinson's disease (PD) and screening for antiparkinsonian treatments in rodents. Recently, the repeated treatment with a low-dose reserpine was proposed as progressive model PD. Rats under this show catalepsy behavior, oral movements spontaneous motor activity decrement. In parallel, compared Wistar rats, spontaneously hypertensive rats (SHR) are resistant acute reserpine-induced dyskinesia. We aimed assess whether SHR would...
The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported of neuronal cells neuroglia rats nonhuman primates during aging. effects senescence on aspects important for understanding some alterations biological rhythms expression. Therefore, our aim was perform a comparative study adult aged female marmoset....
O bioma Caatinga possui uma ampla diversidade e proporciona a população utilização de plantas para fins medicinais. A indústria farmacêutica tem um grande interesse em pesquisar os metabólitos presentes nas espécies desse bioma, além comprovar cientificamente qual patologia pode ser tratada utilizando espécie estudo. Muitas que são utilizadas pela ainda não foram estudadas. Esse estudo teve como objetivo buscar informações acerca das medicinais da Caatinga, reunir as históricas sobre...
Retinal projections in vertebrates reach the primary visual, accessory optic, and circadian timing structures. The central feature of system is principal pacemaker, suprachiasmatic nucleus (SCN) hypothalamus. direct from retina to SCN are considered entrainment pathway system. In this study, unilateral intravitreal injections cholera toxin subunit B were used trace retinal marmoset retinohypothalamic tract reaches ventral bilaterally, as anticipated previous studies. However, labeled fibers...
Purpose: Failure of severed adult central nervous system (CNS) axons to regenerate could be attributed with a reduced intrinsic growing capacity. Severe spinal cord injury is frequently associated permanent loss function because the survivi
In this study, two circadian related centers, the suprachiasmatic nucleus (SCN) and intergeniculate leaflet (IGL) were evaluated in respect to their cytoarchitecture, retinal afferents chemical content of major cells axon terminals rock cavy (Kerodon rupestris), a Brazilian rodent species. The SCN is innervated its ventral portion by from predominantly contralateral retina. It also contains vasopressin, vasoactive intestinal polypeptide glutamic acid decarboxilase immunoreactive cell bodies...