A5012481788- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Congenital heart defects research
- Neural Networks and Applications
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Axon Guidance and Neuronal Signaling
- Time Series Analysis and Forecasting
- Advanced Fluorescence Microscopy Techniques
- Cardiovascular Function and Risk Factors
- Advanced Chemical Sensor Technologies
- Dental Radiography and Imaging
- AI in cancer detection
- MRI in cancer diagnosis
- Developmental Biology and Gene Regulation
- Visual perception and processing mechanisms
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Conditions and Treatments
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Multisensory perception and integration
- Congenital Heart Disease Studies
- Prostate Cancer Treatment and Research
University of Auckland
2019-2024
University of Central Florida
2021-2023
MBF Bioscience (United States)
2021-2023
Neutrophil accumulation is a well-established feature of Alzheimer's disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory vascular pathways. Neutrophils express high levels the oxidant-generating enzyme myeloperoxidase (MPO), however there controversy regarding cellular source localisation MPO in AD brain.We used immunostaining immunoassays quantify neutrophils human tissue microarrays brains APP/PS1 mice. We also multiplexed...
One of the key problems brain faces is inferring state world from a sequence dynamically changing stimuli, and it not yet clear how sensory system achieves this task. A well-established computational framework for describing perceptual processes in provided by theory predictive coding. Although original proposals coding have discussed temporal prediction, later work developing mostly focused on static questions neural implementation properties networks remain open. Here, we address these...
The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds provide...
Prostate-Specific Membrane Antigen (PSMA) PET/CT and multiparametric MRI (mpMRI) are well-established modalities for identifying intra-prostatic lesions (IPLs) in localised prostate cancer. This study aimed to investigate the use of PSMA mpMRI biologically targeted radiation therapy treatment planning by: (1) analysing relationship between imaging parameters at a voxel-wise level (2) assessing performance radiomic-based machine learning models predict tumour location grade.PSMA data from 19...
Visualizing in 3D the histological microanatomy of human olfactory projection from mucosa nasal cavity to bulbs cranial necessitates a workflow for handling great many sections. Here, we assembled reconstruction 7.45 cm
Abstract One of the key problems brain faces is inferring state world from a sequence dynamically changing stimuli, and it not yet clear how sensory system achieves this task. A well-established computational framework for describing perceptual processes in provided by theory predictive coding. Although original proposals coding have discussed temporal prediction, later work developing mostly focused on static questions neural implementation properties networks remain open. Here, we address...
Abstract Lung shape could hold prognostic information for age-related diseases that affect lung tissue mechanics. We sought to quantify mean shape, its modes of variation, and associations with size, age, sex, Body Mass Index (BMI) in healthy subjects across a seven-decade age span. Volumetric computed tomography from 83 (49 M/34 F, BMI $$24.7 \pm 2.7$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>24.7</mml:mn> <mml:mo>±</mml:mo> <mml:mn>2.7</mml:mn>...
We developed and analyzed a single cell scale anatomical map of the rat intrinsic cardiac nervous system (ICNS) across four male three female hearts. find ICNS has reliable structural organizational plan individuals that provide foundation for further analyses in function disease. The distribution was evaluated by 3D visualization data-driven clustering. pattern, distribution, clustering neurons all hearts is highly conserved, demonstrating coherent where distinct clusters are consistently...
ABSTRACT The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds...
Automatic identification of pulmonary lobes from imaging is important in disease assessment and treatment planning. However, the lobar fissures can be difficult to detect automatically, as they are thin, usually fuzzy appearance incomplete on CT scans. The also obscured by or confused with features disease, for example tissue abnormalities that characterise fibrosis. Traditional anatomical knowledge-based methods rely heavily anatomic knowledge largely ignore individual variability, which...
This protocol describes the process of mapping topographical organization tyrosine hydroxylase immune reactive sympathetic postganglionic axons and terminals in mouse heart. Hearts were removed separated as whole mounts, then scanned using confocal or zeiss microscopy
Summary We developed and analyzed a single cell scale anatomical map of the rat intrinsic cardiac nervous system (ICNS) across 4 male 3 female hearts. find ICNS has reliable structural organizational plan individuals that may provide foundation for further analyses in function disease. The distribution was evaluated by 3D visualization using data-driven clustering. pattern, clustering neurons all hearts is highly conserved, demonstrating coherent which distinct clusters are consistently...
We developed a workflow using multi-scale and multi-disciplinary experimental computational approaches to analyze C-looping (the first phase of cardiac looping) the chick across four developing hearts. provide 3D datasets for heart with cell organism level information, including images segmented myocardial cells within heart. used these investigate, as proof-of-concept, differential spatiotemporal patterns growth at both cellular tissue levels, demonstrate how geometrical changes are linked...
Approaches to magnetic resonance (MR) image acquisition and computational modelling often exist in silo. The application of paediatric data is its infancy. This collaborative study addresses this gap for multiple organ systems. State-of-the art MR imaging sequences were selected refined provide the creation subject-specific geometric models. protocol outputs will underpin a longitudinal set Aotearoa New Zealand, generating normative healthy children, identifying early biomarkers pathological...
The sympathetic nervous system plays a crucial role in the control of heart functions. However, distribution and morphology postganglionic innervation has not been well elucidated, which significantly impeded understanding neuroanatomical organization heart. Our goal is to provide map topographical neurons whole mice. In this study, we used Tyrosine hydroxylase (TH) as marker for axons applied combination state-of-the-art techniques, including confocal microscopy, Zeiss Imager flat-mount...
Heart development consists of a series sequential events including looping. Successful looping is vital to normal the heart, and aberrant leads various congenital heart diseases. Looping very complex process and, despite great deal experimental data research, underlying mechanisms controlling phase are unclear. A number hypotheses have been proposed explain process, but none them has yet fully accepted or rejected. In this study, comprehensive workflow developed investigate C-looping (the...
This protocol describes the process of mapping topographical organization tyrosine hydroxylase immune reactive sympathetic postganglionic axons and terminals in mouse heart. Hearts were removed separated as whole mounts, then scanned using confocal or zeiss microscopy