A5000359126- Orthopaedic implants and arthroplasty
- Sports injuries and prevention
- Lower Extremity Biomechanics and Pathologies
- Hip disorders and treatments
- Tendon Structure and Treatment
- Traumatic Brain Injury Research
- Total Knee Arthroplasty Outcomes
- Advanced Neuroimaging Techniques and Applications
- Pelvic and Acetabular Injuries
- Diabetic Foot Ulcer Assessment and Management
- Foot and Ankle Surgery
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Automotive and Human Injury Biomechanics
- Advanced MRI Techniques and Applications
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- Orthopedic Surgery and Rehabilitation
- Breast Cancer Treatment Studies
- Sports Performance and Training
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Bone fractures and treatments
University of Auckland
2016-2025
Medical Research Institute of New Zealand
2023-2024
Mātai Medical Research Institute
2023-2024
Kaiser Permanente
2009-2024
Kaiser Permanente Oakland Medical Center
2006-2024
Griffith University
2014-2022
Colorado Permanente Medical Group
2019-2022
Ningbo University
2022
UCSF Helen Diller Family Comprehensive Cancer Center
2003
University of California, San Francisco
2003
Abstract Background: Preclinical studies have shown the anticancer potential of HMG-CoA reductase enzyme inhibitors (statins), whereas epidemiologic remain controversial. Because lipophilic statins show preclinical activity against hormone receptor [estrogen (ER)/progesterone (PR)]–negative breast cancer models, we explored phenotype cancers that arise in statin users. Methods: We did a retrospective cohort analysis via electronic pharmacy records from Kaiser Permanente Northern California...
The treatment of Achilles tendinopathy is challenging, as 40% patients do not respond to existing rehabilitation protocols. These protocols neglect individual tendon (AT) characteristics, which are crucial for healing the tissue. Although prior studies suggest an optimal strain AT regeneration (6% strains), it unclear if current meet this condition. Our study aimed analyse impact a selection exercises on strains in with tendinopathy, using subject-specific finite element (FE) models free AT....
Objectives: This study examined the impact of a single season rugby union - and subsequent exposure to head acceleration events (HAEs) on functional connectivity in adolescent males compared non-collision sport athletes. Methods: Resting-state MRI scans were acquired from 72 players 20 The cohort scanned longitudinally throughout season. Voxel-wise maps (FC) for 15 resting-state brain networks generated 178 datasets. Cross-sectional comparisons performed between at different stages group....
Musculoskeletal tissues, including tendon, are sensitive to their mechanical environment, with both excessive and insufficient loading resulting in reduced tissue strength. Tendons appear be particularly strain magnitude, there appears an optimal range of tendon that results the greatest positive adaptation. At present, no tools allow localized rapidly measured or estimated training a clinical environment. In this paper, we first review current literature regarding Achilles adaptation,...
Our work combines medical imaging and electromyogram-informed neuromusculoskeletal modeling data to estimate free Achilles tendon strain during selected rehabilitation, locomotor, jumping, landing tasks in trained middle-distance runners. These may potentially be used inform training rehabilitation maximize anabolic remodeling.
The Achilles tendon (AT), the largest in human body has a unique structural feature, that is fascicles AT display spiral twist. However, their functional and roles are still unclear. We used subject-specific computational models tissue mechanical experiment to quantitatively characterize role of fascicle twist tendon. Ten finite element (FE) were developed from ultrasound images. Fascicle was implemented these using material coordinate system available our FE framework. Five different angles...
The Achilles tendon (AT) is the largest of human body and has a primary role in locomotor activities. complex structure AT includes twisting three sub-tendons, non-uniform tissue deformations differential triceps surae muscle forces. main aim this study was to investigate impact commonly used rehabilitation exercises (walking on heels, walking toes, unilateral heel rise, drop with extended knee bent) different twists strains. 3D freehand ultrasound based subject-specific geometry forces...
To produce a patient-specific finite element (FE) model of bone such as the pelvis, complete computer tomographic (CT) or magnetic resonance imaging (MRI) geometric data set is desirable. However, most patient are limited to specific region interest acetabulum. We have overcome this problem by providing hybrid method that capable generating accurate FE models from sparse sets. In paper, we validated our technique with mechanical experiments. Three cadaveric embalmed pelves were strain gauged...
Abstract Background Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment ductal carcinoma situ (DCIS). However, it unknown whether a neoadjuvant (preoperative) anti-estrogen approach to DCIS results any biological change. This study was undertaken investigate pathologic and biomarker changes following endocrine compared group of who did not undergo preoperative anti-estrogenic determine such detectable histologic alterations. Methods Patients (n = 23)...