A5034232647- Pulmonary Hypertension Research and Treatments
- Epilepsy research and treatment
- Cancer Genomics and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Cardiac Arrest and Resuscitation
- Management of metastatic bone disease
- HER2/EGFR in Cancer Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nitric Oxide and Endothelin Effects
- Glioma Diagnosis and Treatment
- Neurology and Historical Studies
- Blood properties and coagulation
- Brain Metastases and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Spine and Intervertebral Disc Pathology
- Respiratory Support and Mechanisms
- Breast Lesions and Carcinomas
- Telemedicine and Telehealth Implementation
- Acute Ischemic Stroke Management
- Medical Imaging and Pathology Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lung Cancer Treatments and Mutations
- Clinical Reasoning and Diagnostic Skills
- Hemodynamic Monitoring and Therapy
- Molecular Biology Techniques and Applications
Beaumont Hospital, Royal Oak
2017-2024
Beaumont Health
2014-2024
Oakland University
2016-2021
McLean Hospital
2021
Imaging Center
2021
Harvard University
2021
University of Bristol
2021
Medical University of South Carolina
2019-2020
RELX Group (United States)
2020
Genomic Health (United States)
2009-2019
Valproate is a first-line treatment for patients with newly diagnosed idiopathic generalised or difficult to classify epilepsy, but not women of child-bearing potential because teratogenicity. Levetiracetam increasingly prescribed these patient populations despite scarcity evidence clinical effectiveness cost-effectiveness. We aimed compare the long-term and cost-effectiveness levetiracetam compared valproate in participants unclassifiable epilepsy.We did an open-label, randomised controlled...
Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty to whether they should be recommended first-line treatments because of insufficient evidence clinical effectiveness cost-effectiveness. We aimed assess the long-term cost-effectiveness levetiracetam compared lamotrigine in people newly diagnosed epilepsy.This randomised, open-label, controlled trial treatment epilepsy. Adult paediatric neurology services across UK recruited...
Surgical decompression of metastatic epidural compression (MEC) improved ambulatory function. Spine radiosurgery can accurately target the tumor and deliver high radiation doses for control. Therefore, a clinical trial was performed to quantitatively determine degree by compression.Sixty-two patients with total 85 lesions were treated. Epidural diagnosed magnetic resonance imaging (MRI) scans. Main criteria inclusion neurological status muscle power 4 5 or better. Radiosurgery involved spine...
In Brief The clinical, pathologic, and molecular features of pleomorphic lobular carcinoma in situ (PLCIS) the relationship PLCIS to classic LCIS (CLCIS) are poorly defined. this study, we analyzed 31 cases (13 apocrine 18 nonapocrine subtypes) compared immunophenotypic, genetic characteristics these with those 24 CLCIS. Biomarker expression was examined using immunostaining for E-cadherin, gross cystic disease fluid protein-15, estrogen, progesterone, androgen receptor, human epidermal...
Each year consumers make a variety of decisions relating to their healthcare. Some experts argue that stronger consumer engagement in about where obtain medical care is an important mechanism for improving efficiency healthcare delivery and financing. Consumers' ability motivation become more active decision makers are affected by several factors, including financial incentives access information. This study investigates the set factors consider when selecting provider, attributes provider...
Introduction In recent years, the use of remote consultations has increased considerably. Many patient encounters in general practice are now conducted by phone or computer as opposed to traditional face-to-face appointments. The aim this study was measure satisfaction with a primary care setting. Aims To assess telephone setting and explore patient's experiences attitudes toward formulate recommendations for potential telehealth improvements. Methods A total 407 patients who had undergone...
This study is to demonstrate the technical and clinical experience of applying image guided spinal radiosurgery for treatment localized metastasis. A dedicated shaped beam unit with intensity modulated radiotherapy (IMRT) x-ray based image-guided (IGRT) were used procedure. total 196 patients 270 lesions metastases treated this procedure from May 2001 October 2005. All received single dose involved spine only. The was escalated 10 18 Gy in 2 increments. using IMRT planning IGRT...
Abstract Background Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment ductal carcinoma situ (DCIS). However, it unknown whether a neoadjuvant (preoperative) anti-estrogen approach to DCIS results any biological change. This study was undertaken investigate pathologic and biomarker changes following endocrine compared group of who did not undergo preoperative anti-estrogenic determine such detectable histologic alterations. Methods Patients (n = 23)...
We have determined the effect of pulsatile flow on segmental vascular resistance in lungs from 29 adult rabbits. In group I (n = 4), II 8), and III 8) were isolated. IV 9) rabbits anesthetized, their chests opened, studied vivo. Group had steady-flow perfusion: with intact vasotonus papaverine treatment. (papaverine treated) perfused for two consecutive 45-min periods steady flow. all isolated five anesthetized rabbits, we measured pressures subpleural 20- to 50-microns-diam arterioles...
We have determined the sites of hypoxic vasoconstriction in ferret lungs. Lungs five 3- to 5-wk-old and adult ferrets were isolated perfused with blood. Blood flow was adjusted initially keep pulmonary arterial pressure at 20 cmH2O left atrial airway pressures 6 8 cmH2O, respectively (zone 3). Once adjusted, kept constant throughout experiment. In each lung, measured subpleural 20- 50-microns-diam arterioles venules micropipette servo-nulling method during normoxia (PO2 approximately 100...
Summary Some chemical indices which could be related to diabetic complications have been assessed in 105 diabetics. In juvenile (insulin-dependent) diabetics with retinopathy, cardiovascular disease or nephropathy, levels of fibrinogen, fibrin monomer, beta-lipoprotein, cholesterol and alpha-2-macroglobulin were raised. Only part is the explanation due a rise fibrinogen age. Among twenty-six patients plasma over 400 mg/100 ml, eleven sustained major catastrophe within next 2 years....
The syndrome of alcoholic ketoacidosis has not been reported in Britain, whereas in-the United States it estimated to occur once for every four cases diabetic ketoacidosis.I We describe two patients with who presented this unit within one month and discuss the pathogenesis features condition. CmlA 41 year old known man casualty department after collapsing street.He had drinking bottles whisky daily three months 10 days eaten little suffered increasingly severe nausea vomiting.He longstanding...