A5103038088- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- MicroRNA in disease regulation
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Hepatitis B Virus Studies
- Clostridium difficile and Clostridium perfringens research
- Alzheimer's disease research and treatments
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Smoking Behavior and Cessation
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- RNA and protein synthesis mechanisms
- Advanced Glycation End Products research
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Neurotransmitter Receptor Influence on Behavior
Shenzhen Institutes of Advanced Technology
2019-2025
Chinese Academy of Sciences
2020-2025
Chengdu University of Traditional Chinese Medicine
2021-2025
Zhejiang Medicine (China)
2025
University of Kentucky
2016-2024
HKUST Shenzhen Research Institute
2021-2023
University of Chinese Academy of Sciences
2022-2023
Center for Excellence in Brain Science and Intelligence Technology
2019-2022
Roche (Sweden)
2022
Scripps (United States)
2021
The involvement of microtubule dynamics on bioelectric activity neurons and neurotransmission represents a fascinating target research in the context neural excitability. It has been reported that alteration cytoskeleton can lead to profound modifications functioning, with putative impact hyperexcitability phenomena. Altogether, present study we pointed at exploring outcomes modulating degree polymerization two electrophysiological epileptiform rat hippocampus. To this aim, used vivo Maximal...
Aims An ongoing outbreak of 2019 novel coronavirus (CoV) disease (COVID‐19), caused by severe acute respiratory syndrome (SARS) CoV‐2, has been spreading in multiple countries. One the reasons for rapid spread is that virus can be transmitted from infected individuals without symptoms. Revealing pathological features early‐phase COVID‐19 pneumonia important understanding its pathogenesis. The aim this study was to explore pulmonary pathology a patient with benign lung lesion. Methods and...
Despite the importance of long non-coding RNAs (lncRNAs) in regulating biological functions, expression profiles lncRNAs sub-regions mammalian brain and neuronal populations remain largely uncharacterized. By analyzing RNASeq datasets, we demonstrate region specific enrichment mRNAs mouse hippocampus pre-frontal cortex (PFC), two major regions involved memory storage neuropsychiatric disorders. We identified 2759 17,859 2561 17,464 expressed PFC. The correspond to ~14% transcriptome PFC ~70%...
Significance Neuronal functions of long noncoding RNAs (lncRNAs) are poorly understood. Here we describe identification and function lncRNA GM12371 in regulating synaptic transmission, synapse density, dendritic arborization primary hippocampal neurons. expression is regulated by cAMP signaling critical for the activity transmission. Importantly, associated with transcriptionally active chromatin regulates several genes involved neuronal growth development. Taken together, these results...
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity L1 that reverse transcribes RNA into cDNA in nucleus. We report also undergoes L1-mediated transcription self-priming cytoplasm independent retrotransposition, providing evidence DNA synthesis this cellular compartment. newly discovered shunt molecule replication cycle induces death retinal pigmented epithelium, a hallmark atrophic...
Histones serve as a major carrier of epigenetic information in the form post-translational modifications which are vital for controlling gene expression, maintaining cell identity, and ensuring proper cellular function. Loss histones aging genome can drastically impact landscape leading to altered chromatin structure changes expression profiles. In this study, we investigated age-related on histone levels acetylation retinal pigment epithelium (RPE) retina mice. We observed global reduction...
Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections formation new ones. Proteins described molecular motors mediate this transport utilize specialized cytoskeletal that function tracks motor based cargos. Molecular kinesins dynein's move along microtubule formed by tubulins whereas myosin actin. Deficits in active gene have been implicated a number neurological disorders. We describe...
Abstract Continuously emerging SARS-CoV-2 Omicron subvariants pose a threat thwarting the effectiveness of approved COVID-19 vaccines. Especially, protection breadth and degree these vaccines against antigenically distant is unclear. Here, we report immunogenicity efficacy bivalent mRNA vaccine, PTX-COVID19-M1.2 (M1.2), which encodes native spike proteins from Wuhan-Hu-1 (D614G) BA.2.12.1, in mouse hamster models. Both primary series booster vaccination using M1.2 elicited potent broad nAbs...
This paper proposes a bionic social learning strategy pigeon-inspired optimization (BSLSPIO) algorithm to tackle cooperative path planning for multiple unmanned aerial vehicles (UAVs) with detection. Firstly, modified (PIO) is proposed, which incorporates strategy. In this modification, the global best replaced by average of top-ranked solutions in map and compass operator, while center local landmark operator. The also proves algorithm’s convergence provides complexity analysis. Comparison...
Diabetic nephropathy (DN) is the leading cause of uremia and clinical mortality, characterized by progressive deterioration kidney structure function due to prolonged exposure hyperglycemia. This condition often necessitates renal replacement therapy for patients with end-stage-renal-disease (ESRD). Consequently, early detection, diagnosis, treatment DN are crucial mitigate disease progression, enhance patient outcomes, maintain a good quality life. Exploring relevant biomarkers diagnosis...
We present SeqOthello, an ultra-fast and memory-efficient indexing structure to support arbitrary sequence query against large collections of RNA-seq experiments. It takes SeqOthello only 5 min 19.1 GB memory conduct a global survey 11,658 fusion events 10,113 TCGA Pan-Cancer datasets. The recovers 92.7% tier-1 fusions curated by Fusion Gene Database reveals 270 novel occurrences, all which are as tumor-specific. By providing reference-free, alignment-free, parameter-free search system, will...
Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions RNA sequencing have made quantitative qualitative assessments transcriptome both possible widely available. RNA-seq provides unprecedented resolution to identify gene structures resolve diversity variants. However, currently available ab initio aligners are vulnerable spurious alignments due random sequence matches sample-reference genome discordance. As...
Metagenomic read classification is a critical step in the identification and quantification of microbial species sampled by high-throughput sequencing. Although many algorithms have been developed to date, they suffer significant memory and/or computational costs. Due growing popularity metagenomic data both basic science clinical applications, as well increasing volume being generated, efficient accurate are high demand.
Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation this system remain elusive. Here, we explore roles KIF5C KIF3A, two members kinesin superfamily molecular motors (Kifs), find that loss function either decreases dendritic arborization spine density whereas gain enhances it. is a rate-determining component local associated with ∼650 RNAs, including...
Alternative splicing (AS) is a regulated process that enables the production of multiple mRNA transcripts from single multi-exon gene. The availability large-scale RNA-seq datasets has made it possible to predict splice junctions, as well sites through spliced alignment reference genome. This greatly enhances capability decipher gene structures and explore diversity variants. However, existing ab initio aligners are vulnerable false positive alignments result sequence errors random matches....
Abstract The cholinergic impairment is an early marker in Alzheimer's disease ( AD ), while the mechanisms are not fully understood. We investigated here effects of glycogen synthase kinse‐3 GSK ‐3) activation on homoeostasis nucleus basalis Meynert NBM ) and frontal cortex, enriched regions. activated ‐3 by lateral ventricular infusion wortmannin WT GF ‐109203X GFX inhibitors phosphoinositol‐3 kinase PI 3‐K) protein C PKC respectively, significantly decreased acetylcholine AC h) level via...