A5076673211- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Tumors and Oncological Cases
- Renal and related cancers
- Teratomas and Epidermoid Cysts
- Hearing, Cochlea, Tinnitus, Genetics
- Renal Diseases and Glomerulopathies
- Hearing Loss and Rehabilitation
- Head and Neck Anomalies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Vestibular and auditory disorders
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Congenital Ear and Nasal Anomalies
- Biological Research and Disease Studies
- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
Medical University of South Carolina
2022
University of Kentucky
2020-2021
Wake Forest University
2020
University of North Carolina at Chapel Hill
2014-2019
Bellevue Hospital Center
1935
Renal carcinoma is a common and aggressive malignancy whose histopathogenesis incompletely understood that largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer recapitulate the genomic alterations found in human papillary (pRCC) clear cell RCC (ccRCC), most subtypes. MYC activation results highly penetrant pRCC tumours (MYC), while activation, when combined with Vhl Cdkn2a (Ink4a/Arf) deletion (VIM), produce approximate ccRCC. RNAseq demonstrate resemble...
ABSTRACT Tubulointerstitial fibrosis (TIF) is recognized as a final phenotypic manifestation in the transition from chronic kidney disease (CKD) to end-stage renal (ESRD). Here we show that conditional inactivation of Sav1 mouse epithelium resulted upregulated expression profibrotic genes and TIF. Loss induced Stat3 activation senescence-associated secretory phenotype (SASP) coincided with development tubulointerstitial fibrosis. Treatment mice YAP inhibitor verteporfin (VP) inhibited...
The purpose of this study was to explore the genomic landscape head and neck squamous cell carcinoma (HNSCC) in circulation (circulating tumor DNA [ctDNA]) (tumor tissue [tDNA]) understand implications ctDNA sequencing for prognosis precision oncology treatments.This is a retrospective review 75 patients with HNSCC both tDNA ctDNA. Results were analyzed concordance between their individual combined association demographics, survival, presence extent disease at last visit (DLV).The five most...
PARP inhibitors are currently approved for a limited number of cancers and targetable mutations in DNA damage repair (DDR) genes. In this single-institution retrospective study, the profiles 170 patients with head neck squamous cell cancer (HNSCC) available tumor tissue (tDNA) circulating (ctDNA) results were analyzed set 18 DDR genes as well gene subsets defined by technical clinical significance. Mutations correlated demographic outcome data. The addition ctDNA to standard tDNA analysis...
Rapamycin derivatives allosterically targeting mTOR are currently FDA approved to treat advanced renal cell carcinoma (RCC), and catalytic inhibitors of mTOR/PI3K now in clinical trials for treating various solid tumors. We sought investigate the relative efficacy allosteric versus inhibition, evaluate crosstalk between MEK/ERK pathways, as well therapeutic potential dual MEK inhibition RCC. Pharmacologic (rapamycin BEZ235) genetic manipulation pathway were evaluated by vitro assays...
Adults with hearing loss are at risk of negative impacts the pandemic. Specific factors, such as severity and location residence, may disproportionately impact patients during The objective this study was to assess relative COVID-19 pandemic on patients, based device type residence.Prospective cross-sectional questionnaire study.Tertiary referral center.Adults loss.Data included sociodemographic data, communication challenges, preparedness, access healthcare, mental emotional health.A total...
Congenital nasal pyriform aperture stenosis (CNPAS) is a rare condition related to holoprosencephaly in which bony overgrowth of the medial process maxilla narrows aperture. CNPAS presents neonates with signs upper airway obstruction ranging from mild severe respiratory distress and failure thrive. Surgical intervention indicated after failed conservative measures generally includes temporary stent placement. We report series 3 cases treated surgically, examine postoperative care...
Floor of mouth (FOM) dermoid cysts are a rare but clinically significant lesion the head and neck. Classically, large have been excised via transcervical approach, although limits transoral approach expanding. The majority FOM present in midline, true lateral reported. In this case series, we describe 3 pediatric patients who all underwent successful excision massive cysts, along with literature review. Massive cystic lesions were identified on preoperative imaging. averaged 6 × 4.3 5 cm...