A5077366693- Retinal Development and Disorders
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Traditional Chinese Medicine Studies
- CO2 Sequestration and Geologic Interactions
- Ultrasonics and Acoustic Wave Propagation
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Lipid Membrane Structure and Behavior
- Telomeres, Telomerase, and Senescence
- Nuclear Receptors and Signaling
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Geothermal Energy Systems and Applications
- Geophysical Methods and Applications
- RNA regulation and disease
- Health and Wellbeing Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Health and Well-being Studies
- Thermography and Photoacoustic Techniques
- Spacecraft and Cryogenic Technologies
East Tennessee State University
2021-2025
University of Kentucky
2023
Korea University
2013
Korea Engineering Consultants Corporation
2013
University of Tennessee at Knoxville
2007
Histones serve as a major carrier of epigenetic information in the form post-translational modifications which are vital for controlling gene expression, maintaining cell identity, and ensuring proper cellular function. Loss histones aging genome can drastically impact landscape leading to altered chromatin structure changes expression profiles. In this study, we investigated age-related on histone levels acetylation retinal pigment epithelium (RPE) retina mice. We observed global reduction...
Aging of the retinal pigment epithelium (RPE) leads to a gradual decline in RPE homeostasis over time, significantly impacting health. Understanding mechanisms underlying aging is crucial for elucidating background which many age-related pathologies develop. In this study, we compared transcriptomes young and aged mouse observed marked upregulation immunogenic, proinflammatory, oxidative stress genes RPE. Additionally, exhibited dysregulation pathways associated with visual perception...
The purpose of this study was to evaluate the validity Deficiency and Excess Pattern Identification Questionnaire. number subjects enrolled in 431. Pearson Correlation Coefficient analysis were conducted reveal correlation among Questionnaire, Grip Strength Quality life. ROC-curve used suggest optimal cut off value. Cohen Kappa also analyze for diagnostic validity. significant p-value < .05. questionnaire had positive with score expert negative life (p<.001). value 56.5 separate deficiency...
The CRISPR/Cas9 system is a robust, efficient, and cost-effective gene editing tool widely adopted in translational studies of ocular diseases. However, vivo CRISPR-based animal models poses challenges such as the efficient delivery CRISPR components viral vectors with limited packaging capacity Cas9-associated immune response. Using germline Cas9-expressing mouse model would help to overcome these limitations. Here, we evaluated long-term effects SpCas9 expression on retinal morphology...
The aim of this study is to evaluate the performance GHP system with 45 cast-in-place energy piles(CEP) for a commercial building. In order demonstrate feasibility sustainable system, transient simulations were conducted over 1-year and 20-year periods, respectively. simulation results showed that maximum minimum temperatures brine returning from CEPs <TEX>$23.91^{\circ}C$</TEX> <TEX>$6.66^{\circ}C$</TEX>, which in range design target temperatures. addition, after 20 years' operation, these...
가스터빈 날개를 덮고 있는 덮개판(Lock plate)의 재료 물성을 유도초음파를 이용하여 측정을 하였다. Lock plate는 발전소에서 아무 극한 환경에서 작동을 하는 부분 중 하나이다. 초음파 속도와 감쇠계수가 서로 다른 3가지 조건의 열처리상태의 측정하는데 사용되었다. 일반적인 기계적 파괴 인장 실험과 비교했을 때, 인코넬 x-750의 재료특성은 열처리 조건에서 탄성계수와 포아슨비를 활용하여 비파괴적인 방법으로 더 효과적으로 알아냈다. 강도는 비례관계에 있으며, 이러한 재료물성 측정은 여러 산업 분야에서 손상 측정에 활용될 수 있다. 또한 유도초음파 기법을 장거리, 광범위한 진단으로 시간과 비용을 절감하는데 도움이 되리라 기대된다.