A5077982245- HIV/AIDS drug development and treatment
- Synthesis and biological activity
- HIV Research and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Chemical and Physical Properties in Aqueous Solutions
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Chemistry and Chromatography
- Antimicrobial Peptides and Activities
- Biochemical and Molecular Research
- Curcumin's Biomedical Applications
- Synthesis of Tetrazole Derivatives
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Metal complexes synthesis and properties
- HIV/AIDS Research and Interventions
University of Allahabad
2015-2024
Maharaja Yeshwantrao Hospital
2024
Mahatma Gandhi Memorial Medical College
2024
North Eastern Regional Institute of Science and Technology
2023
Guru Gobind Singh Indraprastha University
2022
Chapman University
2021
Target (United States)
2021
Subharti Medical College
2017
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2013
Mahatma Gandhi Kashi Vidyapith
2012
Federated learning (FL) is proposed as a different approach for distributed on the edges while maintaining privacy. Existing FL methods, are mainly focused deep classifying and clustering models, with little consideration offered to federated reinforcement (FRL) task edge, difficult in which several trained agents track local state take actions train global model without disclosing their dataset. Several neural network models based FRL have been presented recently determine best method...
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity L1 that reverse transcribes RNA into cDNA in nucleus. We report also undergoes L1-mediated transcription self-priming cytoplasm independent retrotransposition, providing evidence DNA synthesis this cellular compartment. newly discovered shunt molecule replication cycle induces death retinal pigmented epithelium, a hallmark atrophic...
In view of the low toxicity NNRTIs in comparison to NRTIs, a new series diarylpyrimidine derivatives has been designed as against HIV-1. silico studies using DS 3.0 software have shown that these compounds behaved while interacting at allosteric site HIV-RT. The promising docking results, which revealed all formed hydrogen bonds with Lys101, Lys103, Tyr181, Tyr318 and π- interactions Tyr188, Phe227 Trp229 amino acid residues located non-nucleoside inhibitor binding pocket (NNIBP) HIV-RT...
Different arabinosides and ribosides, viz. Ara‐DDA or 9(1‐β‐d‐arabinofuranosyl) 1,3‐dideazaadenine (6), Ara‐NDDP 4‐nitro‐1,3‐dideazapurine (7), Ara‐DKP 1(1‐β‐d‐arabinofuranosyl) diketopiperazine (8), Ribo‐DDA 9(1‐β‐d‐ribofuranosyl) (9) Ribo‐NDDP (10) have been synthesized as probable antiviral agents. The using the catalyst TDA‐1 that causes stereospecific formation of β‐nucleosides while a one‐pot synthesis procedure was adopted for ribonucleosides where β‐anomers were obtained in higher...
A series of hybrid 4-aminoquinoline 1,3,5-triazine derivatives was synthesized and their chemical structure were confirmed by 1H-NMR, 13C-NMR, FT-IR mass spectrometric analyses. In vitro antimalarial activity these compounds evaluated against chloroquine-sensitive (3D-7) chloroquine resistant (RKL-2) strains P. falciparum. Results showed that all had considerable both the further docking studies performed on wild type (1J3I.pdb) quadruple mutant (N51I, C59R, S108 N, I164L, 3QG2.pdb)...
Bi-functional conjugates comprised of 4-aminoquinoline and 1,3,5-triazine were synthesized through facile synthetic routes. These compounds rigorously screened for determination their antimalarial activity against wild mutant cultured Plasmodium falciparum. The results disclosed that the have considerable both parasites with marked variation on changing pattern substitutions. observed profiles additionally substantiated by docking studies quadruple P. falciparum dihydrofolate reductase...
Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds 8c 8f found active against Gram positive negative microorganisms. Molecular docking studies have been performed on eubacterial ribosomal decoding A site (Escherichia coli 16S rRNA site) to rationalize the probable mode of action, binding affinity, orientation molecules at receptor. The structures all these newly compounds confirmed by their elemental analyses spectral...
A new series of quinoline derivatives has been designed and synthesized as probable protease inhibitors (PIs) against severe acute respiratory syndrome coronavirus 2. In silico studies using DS v20.1.0.19295 software have shown that these compounds behaved PIs while interacting at the allosteric site target Mpro enzyme (6LU7). The promising docking results, which revealed all formed hydrogen bonds with His41, His164, Glu166, Tyr54, Asp187, showed π-interaction highly conserved amino acids in...
As the menace of HIV/AIDS continues to rise, effective drug treatments are required reach infected masses. HAART provides durable control virus replication, however, it is not devoid unwanted side effects, especially in persons undergoing long-term treatment. The current therapy finds its limitations emergence multidrug resistance, transmission drug-resistant HIV strains, and a life-long Moreover, improve patient adherence simplify treatments, fixed dose combinations (FDCs) needed. picture...