A5101439831- Statistical Methods in Clinical Trials
- Flavonoids in Medical Research
- Nausea and vomiting management
- Chronic Lymphocytic Leukemia Research
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Air Quality and Health Impacts
- Microbial Natural Products and Biosynthesis
- Hormonal and reproductive studies
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pregnancy and Medication Impact
- Esophageal Cancer Research and Treatment
- Marine Sponges and Natural Products
- Cellular Mechanics and Interactions
- Advanced Causal Inference Techniques
- Cerebral Venous Sinus Thrombosis
- Pharmacovigilance and Adverse Drug Reactions
- Lung Cancer Diagnosis and Treatment
- Optimal Experimental Design Methods
- Pharmacological Effects and Toxicity Studies
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2022-2024
Center for Global Health
2023
Nanjing University
2021
Beijing Institute of Technology
2019
University of Pittsburgh
2013-2016
Quest Diagnostics (United States)
2013
Emory and Henry College
2013
Cancer Institute (WIA)
2013
Rutgers, The State University of New Jersey
2010-2013
Background The optimal dosages, timing, and treatment sequencing for standard-of-care neoadjuvant chemoradiotherapy necessitate re-evaluation when used in conjunction with immune checkpoint inhibitors patients resectable, locally advanced esophageal squamous cell carcinoma (RLaESCC). SCALE-1 phase Ib study aimed to evaluate the safety efficacy of short-course radiotherapy combined chemotherapy toripalimab this patient population. Methods RLaESCC clinical stages cT3-4aN0M0/cT1-4aN+M0 received...
Tocopherols and tocotrienols, collectively known as vitamin E, are essential antioxidant nutrients. The biological fates metabolite profiles of the different forms not clearly understood. objective this study is to simultaneously analyze metabolites tocopherols tocotrienols in mouse human samples. Using HPLC/electrochemical detection mass spectrometry, 18 tocopherol-derived 24 tocotrienol-derived side-chain degradation were identified fecal Short-chain metabolites, particular γ-...
Abstract Epidermal growth factor receptor (EGFR) and COX-2 inhibitors synergistically inhibit head neck squamous cell carcinoma tumorigenesis in preclinical studies. We conducted a phase I pharmacokinetic study with the erlotinib celecoxib combination patients advanced premalignant lesions. Thirty-six subjects oral leukoplakia, mild, moderate, or severe dysplasia, situ were screened for participation; 12 consented received therapy median of 5.38 months. Erlotinib was escalated following...
Treatment strategy for hepatocellular carcinoma (HCC) and Vp4 [main trunk] portal vein tumor thrombosis (PVTT) remains limited due to posttreatment liver failure. We aimed assess the efficacy of irradiation stent placement with 125 I plus transcatheter arterial chemoembolization (TACE) (ISP-TACE) compared sorafenib TACE (Sora-TACE) in these patients.In this multicenter randomized controlled trial, participants HCC PVTT without extrahepatic metastases were enrolled from November 2018 July...
Aims The association of sleep traits (insomnia, duration, chronotype, daytime sleepiness, and snoring) with benign prostatic hyperplasia (BPH) is unclear. This research aimed to examine the effects on BPH risk. Methods A total 170 241 men aged 38 73 years from UK Biobank were included. An overall healthy score was created based five traits. Cox regression model utilized compute adjusted hazard ratios (HRs) population attributable fractions (PAFs) 95% confidence intervals (CIs) for risk in...
4063 Background: Adding PD-1 inhibitors to neoadjuvant chemoradiotherapy have shown promising results in treatment of locally advanced esophageal squamous cell carcinoma (ESCC). However, there is a need explore more effective and safe doses schedules. The aim this single arm phase Ib trial determine the safety efficacy short course chemo-radiotherapy plus toripalimab following by esophagectomy patients with resectable ESCC. Methods: Patients (pts) histopathologically confirmed thoracic ESCC,...
Two novel sorbicillinoid analogues, (4'Z)-sorbicillin (1) and (2S)-2,3-dihydro-7-hydroxy-6-methyl-2-[(E)-prop-1-enyl]-chroman-4-one (2), together with three known compounds, (2S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]-chroman-4-one (3), sorbicillin (4), 2',3'-dihydrosorbicillin (5), were isolated from the culture broth of fungus Trichoderma sp. associated seastar Acanthaster planci. Their structures determined by analysis NMR MS data. Compound I was first example a...
Background: Ibrutinib and zanubrutinib are Bruton tyrosine kinase inhibitors used to treat mantle cell lymphoma, chronic lymphocytic leukemia, small lymphoma. Dihydroxydiol ibrutinib (DHI) is an active metabolite of the drug. A liquid chromatography–tandem mass spectrometry method was developed detect ibrutinib, DHI, in human plasma. Methods: The involved a protein precipitation step, followed by chromatographic separation using gradient 10 mM ammonium acetate (containing 0.1% formic...
Late-onset (more than 48 h after ICU admission) acute respiratory distress syndrome (ARDS) is associated with shorter survival time and higher mortality; however, the underlying molecular targets remain unclear. As
Statistical analysis is critical in medical research. The objective of this article to summarize the appropriate use and reporting commonly used statistical methods research, on basis existing guidelines authors’ experience reviewing manuscripts, provide recommendations for applications reporting.
Ibrutinib, orelabrutinib, and zanubrutinib are all Bruton's tyrosine kinase inhibitors, which have greatly improved the treatment of B-cell malignancies. In this study, an LC-MS/MS method was developed validated for determination zanubrutinib, ibrutinib, its active metabolite dihydrodiol ibrutinib in human plasma. The Ibrutinib-d5 used as internal standard. Pretreatment performed using a simple protein precipitation step acetonitrile. ACQUITY UPLC HSS T3 column (2.1×50 mm, 1.8 μm) to...
A liquid chromatography-tandem mass spectrometric method for the quantification of granisetron and its major metabolite, 7-hydroxy in human plasma urine samples was developed validated. Respective stable isotopically labeled were used as internal standards (IS). Chromatography performed using an Xselect HSS T3 analytical column with a mobile phase 20% acetonitrile water (containing 0.2 mM ammonium formate 0.14% formic acid, pH 4) delivered isocratic mode. Tandem spectrometry operating...
Aim: Caffeine is a central nervous system stimulant, used to treat apnea of prematurity. A hydrophilic interaction chromatography-tandem mass spectrometry (HILIC-MS/MS) approach was developed detect caffeine, paraxanthine, theophylline and theobromine in premature infants. Method: Protein precipitation plasma samples (10 μl) carried out by treating with acetonitrile containing caffeine-13C3. The separation on an ACQUITY HPLC® BEH HILIC column. its metabolites were quantified multiple...
On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A-B (1-2), were identified the culture of Alternaria alternate L-10. Their structures established by a combination spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways compounds 1-2 also proposed.
Abstract Conditional power (CP) serves as a widely utilized approach for futility monitoring in group sequential designs. However, adopting the CP methods may lead to inadequate control of type II error rate at desired level. In this study, we introduce flexible beta spending function tailored regulate while employing based on predetermined standardized effect size (a so‐called CP‐beta function). This delineates expenditure across entirety trial. Unlike other existing functions, seamlessly...
While maternal exposure to high metal levels during pregnancy is an established risk factor for birth defects, the role of paternal remains largely unknown. We aimed assess associations prenatal and parental coexposure with defects in singletons. This study conducted within Jiangsu Birth Cohort recruited couples early pregnancy. measured their urinary concentrations 25 metals. A total 1675 parent-offspring trios were included. The prevalence any among infants by one year age was 7.82%....
Importance Maternal hypertensive disorder in pregnancy (HDP) might affect ocular health offspring; however, its association with strabismus remains unclear. Objective To examine the of maternal HDP overall and type-specific offspring. Design, Setting, Participants In Jiangsu Birth Cohort study, a population-based study China, pregnant women were recruited from April 24, 2014, to November 30, 2018. A total 6195 offspring had diagnosis information, whom 3078 excluded due having no information...
Background: Orelabrutinib is a second-generation Bruton tyrosine kinase inhibitor that improves the management of B-cell malignancies. The objective this study was to develop and validate an LC-MS/MS method for quantifying orelabrutinib in human plasma. Methods: Plasma samples were processed using acetonitrile precipitate proteins. Ibrutinib-d5 used as internal standard. mobile phase comprised 10 mM ammonium formate containing 0.1% formic acid (62:38, vol/vol). multiple reaction monitoring...
Abstract We developed and validated sensitive MS/MS methods for the determination of venetoclax, an oral selective B‐cell lymphoma‐2 inhibitor, in human plasma cerebrospinal fluid (CSF). Acetonitrile was used as protein precipitant. The mobile phase 10 mM ammonium formate consisting 0.1% formic acid acetonitrile (40:60, v/v). analytes were separated on ACQUITY UPLC HSS T3 column (2.1 × 50 mm, 1.8 μm) 5 min. An API 4000 mass spectrometer selected to quantify venetoclax internal standard using...