A5101995219- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Invertebrate Immune Response Mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- RNA regulation and disease
- Evolutionary Game Theory and Cooperation
- Genetic Associations and Epidemiology
- Aquaculture Nutrition and Growth
- Cardiovascular Syncope and Autonomic Disorders
- Diet and metabolism studies
- Cardiac Arrhythmias and Treatments
- Extracellular vesicles in disease
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Immune cells in cancer
- Tryptophan and brain disorders
- Mine drainage and remediation techniques
- Pain Management and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Neurological diseases and metabolism
Guangxi Medical University
2018-2024
Guangdong Ocean University
2020-2024
State Key Laboratory of Natural Medicine
2018-2023
China Pharmaceutical University
2018-2023
Nanjing Forestry University
2023
Soochow University
2019-2022
Guangdong Medical College
2022
Southwest Jiaotong University
2022
Anhui Jianzhu University
2022
China University of Mining and Technology
2022
Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy currently. Although activation the innate immune stimulator interferon genes (STING) pathway potentiates antitumor immunity and thus sensitizes tumors to ICIs, efficient tumor penetration STING agonists remains critically challenging. Herein, we prepare tumor-penetrating neotype neutrophil cytopharmaceutical...
A combination of metabolic reprogramming and T cell therapy via surface anchor-engineering results in improved efficacy immunotherapy solid tumors.
Ferroptosis is a type of cell death induced by the iron-dependent accumulation lipid hydroperoxides and reactive oxygen species (ROS) in cells. Inhibiting ferroptosis important for improving survival transplanted bone marrow-derived mesenchymal stem cells (BMSCs). Although it known that NOP2/Sun RNA methyltransferase 5 (NSUN5) post-transcriptionally regulates BMSCs through methylation, precise mechanisms underlying these effects have not been reported. In this study, we demonstrate NSUN5...
A nine-week feeding trial was conducted to evaluate the effects of replacing wheat bran (WB) with palm kernel cake (PKC) or fermented (FPKC) on growth performance, intestinal microbiota and health genetically improved farmed tilapia (GIFT, Oreochromis niloticus) (initial weight 7.00 ± 0.01 g). Eleven isonitrogenous isolipidic experimental diets were formulated by 0, 20, 40, 60, 80, 100% dietary WB PKC FPKC. Replacement concentrations up 80% had no significant effect rate feed utilisation (p...
Circular RNAs (circRNAs) play important roles in a variety of physiological and pathological processes. Researches demonstrated that circRNAs provided novel strategies for the prevention treatment IS. However, biological function hsa_circ_0045932 (circUSP36) has not been revealed yet. Here, we explored effect circUSP36 on IS its mechanism. In present study, found expression was significantly decreased peripheral blood patients negatively correlated with severity, infarct volume poor...
Abstract The prevalence of coronary artery disease (CAD) in Tibetan Highlanders is lower than that plain-living individuals, but the mechanism still unclear. Gut microbiota (GM) disorder considered one potential factors involved pathogenesis CAD, GM characteristics suffering from CAD are unknown. We sequenced V3-V4 region 16S ribosomal RNA gut bacteria fecal samples and Han patients healthy individuals inhabiting Qinghai-Tibet Plateau, as well living at sea level, we analyzed these subjects...
Abstract Aim This study was designed to investigate the value of history taking in identifying children with cardiac syncope, and improve diagnostic efficiency accuracy syncope. Methods Results We compared characteristics a group adolescents syncope at Pediatric Syncope Unit five hospitals China those typical vasovagal included cohort 275 patients Unit. A cause established 31 patients, autonomic-mediated reflex 214, non-syncopal attacks 15, remaining 15 remained unexplained. Cardiac...
At present, peptidoglycan (PGN) is commonly used as an immunostimulant in shrimp. However, little has been known about its mechanism. In this study, comparative transcriptome analysis was employed to investigate the impact of dietary PGN on immune response Litopenaeus vannamei. A total 720 healthy juvenile L. vannamei (initial weight 0.31 ± 0.05 g) were randomly evenly allocated 18 fibreglass buckets 6 groups, fed with six isonitrogen (41.05%) and isolipid diets (8.16%) containing at doses 0...
An 8-week feeding experiment was conducted to investigate the effect of dietary histamine on growth performance, digestive physiology function and muscle quality in a hybrid grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂). Seven isoproteic (50%) isolipidic (11%) diets were prepared with various inclusion levels 0, 30, 60, 120, 240, 480 960 mg/kg (actual contents 72.33, 99.56, 138.60, 225.35, 404.12, 662.12 1245.38 mg/kg), respectively. Each diet randomly assigned triplicates...
Coal mining can cause groundwater pollution, and microorganism may reflect/affect its hydrochemical characteristics, yet little is known about the microorganism’s distribution characteristics influence on formation evolution of mine water quality in underground coal mines. Here, we investigated microbial communities six typical zones a North China coalfield. The results showed that compositions samples displayed apparent zone-specific patterns. community diversity followed order surface...
Huaguangjiao I refers to the ancient Chinese wooden shipwreck of South Song Dynasty (1127–1279 AD) discovered in China Sea 1996. From 2008 2017, archaeological waterlogged wood was desalted using deionized water combined with ultrasonic treatment, and EDTA-2Na, EDTAHO, NaH2PO4·2H2O solutions. In this paper, degree degradation modified moisture content main components were determined. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nanoindentation (NI), scanning...
The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential molecular target for anticancer-drug discovery. In this study, series of nonsteroidal D mimics with phenyl-pyrrolyl pentane skeletons therapeutic potentials in cancer treatment were synthesized. Among them, 11b and 11g identified as most effective agents reducing viability four cancer-cell lines, particularly those breast-cancer cells, IC50 values submicromolar-concentration range. addition,...