A5102735551- Vitamin D Research Studies
- Estrogen and related hormone effects
- Music and Audio Processing
- Liver physiology and pathology
- Neural Networks and Applications
- Cancer therapeutics and mechanisms
- Music Technology and Sound Studies
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Neurological Disorders and Treatments
- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Bioactive Compounds and Antitumor Agents
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Gastrointestinal motility and disorders
- Synthesis and biological activity
Tsinghua University
2025
State Key Laboratory of Natural Medicine
2018-2023
China Pharmaceutical University
2018-2023
Model Animal Research Center
2016-2018
Nanjing University
1993-2018
Tianjin Medical University
2018
State Key Laboratory of Pharmaceutical Biotechnology
2016
Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy currently. Although activation the innate immune stimulator interferon genes (STING) pathway potentiates antitumor immunity and thus sensitizes tumors to ICIs, efficient tumor penetration STING agonists remains critically challenging. Herein, we prepare tumor-penetrating neotype neutrophil cytopharmaceutical...
A combination of metabolic reprogramming and T cell therapy via surface anchor-engineering results in improved efficacy immunotherapy solid tumors.
Cholesterol crystals (CCs), originally accumulating in the lysosome of cholesterol-laden cells, can aggravate progression atherosclerosis. β-cyclodextrin (CD) is a potent cholesterol acceptor or CC solubilizer. However, random extraction impedes vivo application CD for removing lysosomal CCs. Here, we exploit poly-β-cyclodextrin (pCD) as solubilizer and dextran sulfate grafted with benzimidazole (BM) pH-sensitive switch (pBM) to self-assemble into supramolecular nanoassembly (pCD/pBM-SNA)....
Abstract While apoptosis is essential for male germ cell development, improper activation of in the testis can affect spermatogenesis and cause reproduction defects. Members MAGE-A (melanoma antigen family A) gene are frequently clustered mammalian genomes exclusively expressed testes normal animals but abnormally activated a wide variety cancers. We investigated potential roles these genes by generating mouse model with 210-kb genomic deletion encompassing six members Magea cluster ( Magea1...
Abstract Repetitive transcranial magnetic stimulation (rTMS) and mesenchymal stem cells (MSCs) transplantation both showed therapeutic effects on cognition impairment in vascular dementia (VD) model rats. However, whether these two therapies have synergistic the molecular mechanisms remain unclear. In our present study, rats were randomly divided into six groups: control group, sham operation VD MSC rTMS MSC+rTMS group. The prepared using a modified 2VO method. treatment was implemented at...
In a pancreatic tumor microenvironment, activated stellate cells (PSCs) produce extracellular matrix (ECM) to form barrier drug penetration. Moreover, the interaction between cancer and PSCs promotes growth. Vitamin D receptor (VDR), as key regulator promote recovery of resting state, is an attractive therapeutic target for cancer. Herein, we reported design synthesis 57 nonsecosteroidal VDR modulators based on skeleton phenyl-pyrrolyl pentane. Among them, compounds C4, I5, I8 exhibited...
Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis and target the thiazolidinedione (TZD) class antidiabetic drugs; therefore, identifying novel regulators PPARγ action in adipocytes essential for future development therapeutics diabetes. MAGE family member D1 (MAGED1), by acting as an adaptor ubiquitin-dependent degradation pathways co-factor transcription, plays important role neural development, cell differentiation circadian rhythm. Here, we showed...
The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential molecular target for anticancer-drug discovery. In this study, series of nonsteroidal D mimics with phenyl-pyrrolyl pentane skeletons therapeutic potentials in cancer treatment were synthesized. Among them, 11b and 11g identified as most effective agents reducing viability four cancer-cell lines, particularly those breast-cancer cells, IC50 values submicromolar-concentration range. addition,...
Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) components and results in impaired liver function. Vitamin D plays a critical role the development as it inhibits transforming growth factor β1 (TGFβ1)-induced ECM activated hepatic stellate cells (HSCs). Here, series novel nonsecosteroidal vitamin receptor (VDR) agonists with phenyl-pyrrolyl pentane skeleton was designed synthesized. Among them, seven compounds including 15a exhibited more efficient...
Despite the significant progress in controllable music generation and editing, challenges remain quality length of generated due to use Mel-spectrogram representations UNet-based model structures. To address these limitations, we propose a novel approach using Diffusion Transformer (DiT) augmented with an additional control branch ControlNet. This allows for long-form variable-length editing controlled by text melody prompts. For more precise fine-grained control, introduce top-$k$...