A5100345968- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Complement system in diseases
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Antimicrobial Peptides and Activities
- Vibrio bacteria research studies
- Aquatic life and conservation
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Trypanosoma species research and implications
- interferon and immune responses
- Galectins and Cancer Biology
- Marine Bivalve and Aquaculture Studies
- Phagocytosis and Immune Regulation
- Protein Hydrolysis and Bioactive Peptides
- Parasites and Host Interactions
- Gut microbiota and health
- Microbial infections and disease research
- Plant Molecular Biology Research
- Hemoglobinopathies and Related Disorders
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Viral Infectious Diseases and Gene Expression in Insects
Dalian Ocean University
2017-2025
Shanxi Agricultural University
2025
Nanjing Drum Tower Hospital
2024
Guangdong Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Qingdao National Laboratory for Marine Science and Technology
2018-2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023
Guangdong Ocean University
2022-2023
Center of Hubei Cooperative Innovation for Emissions Trading System
2023
Wenzhou Medical University
2022-2023
Three types of ficolins have been identified in humans: L-ficolin, M-ficolin, and H-ficolin. Similar to mannose-binding lectin, L-ficolin H-ficolin are the recognition molecules lectin complement pathway. Another human ficolin, is a nonserum ficolin that expressed leukocytes lung; however, little known about its physiologic roles. In this study, we report characterization M-ficolin terms protein localization activity. was localized secretory granules cytoplasm neutrophils, monocytes, type II...
Previous studies have shown that both hepatitis A virus and C inhibit innate immunity by cleaving the mitochondrial antiviral signaling (MAVS) protein, an essential component of virus-activated pathway activates NF-kappaB IFN regulatory factor-3 to induce production type I IFN. For human B (HBV), s-Ag, e-Ag, or HBV virions been suppress TLR-induced activity with reduced IFN-beta subsequent induction IFN-stimulated genes. However, HBV-mediated suppression RIG-I-MDA5 is unknown. In this study,...
Mannose-binding lectin (MBL) and ficolin are complexed with MBL-associated serine proteases, key enzymes of complement activation via the pathway, act as soluble pattern recognition molecules in innate immune system. Although numerous reports have revealed importance MBL infectious diseases autoimmune disorders, role is still unclear. To define specific vivo, we generated model mice deficient ficolins. The A (FcnA)-deficient (Fcna(-/-)) FcnA/ficolin B double-deficient (Fcna(-/-)b(-/-))...
This study investigated the effects of dietary iron supplementation on water quality, plant growth, and fish health in an aquaponic system over 90 days. Iron significantly improved with increased height, stem diameter, leaf count, fruit yield tomatoes (Solanum lycopersicum) pak choi (Brassica rapa subsp. Chinensis) (p < 0.05). The pH fluctuated varying content, higher levels promoted better growth by improving availability During first 60 days, all red blood cell counts hemoglobin...
Destruxin A is a mycotoxin that secreted by entomopathogenic fungi which has broad-spectrum insecticidal effect. Previous transcript and protein profiling analysis showed destruxin significant effects on the expression of serine protease inhibitor genes (serpin-2, 4, 5) in larvae Plutella xylostella. In current study, we aimed to understand role serpins under application A. We obtained two full-length cDNA sequences P. xylostella serpins, named serpin-4 serpin-5, cloned serpin-2 gene whose...
Ulcerative colitis (UC) is a main form of inflammatory bowel disease. Due to complicated etiology and high rate recurrence, it quite essential elucidate the underlying mechanism search for effective therapeutic methods UC.To investigate effects astragalus polysaccharides (APS) combined with matrine on UC associated lung injury.UC was induced in rats by colon mucosal tissue sensitization trinitro-benzene-sulfonic acid-ethanol. Then, treatments salazopyrine, APS, matrine, APS histopathological...
This study aimed to evaluate the effects of soluble and insoluble non-starch polysaccharides (NSPs) on growth performance, digestive enzyme activity, antioxidant capacity, intestinal flora juvenile GIFT tilapia ( Oreochromis niloticus ). Four isonitrogenous isolipidic experimental diets were formulated, including FM diet (0% NSPs, FM), INSP (5.8% INSP), SNSP (12.2% SNSP), NSP 12.2% SNSP, NSPs). Each was fed triplicate groups 40 fish (2.14 ± 0.04 g) per repetition for 10 weeks. Results showed...
DM9 domain containing protein (DM9CP) is a family of newly identified recognition receptors exiting in most organisms except plants and mammals. In the current study, to our knowledge, novel DM9CP-5 (CgDM9CP-5) with two tandem repeats high expression level gill was from Pacific oyster, Crassostrea gigas. The deduced amino acid sequence CgDM9CP-5 shared 62.1% identity CgDM9CP-1 C. gigas, 47.8% OeFAMeT Ostrea edulis. recombinant (rCgDM9CP-5) able bind d-mannose, LPS, peptidoglycan,...
DM9 refers to an uncharacterized protein domain that is originally discovered in Drosophila melanogaster . Two proteins with repeats have been recently identified from Pacific oyster Crassostrea gigas as mannose-specific binding pattern-recognition receptors (PRRs). In the present study, a novel member of containing (designated Cg DM9CP-4) was C. DM9CP-4, about 16 kDa only two tandem domains, highly enriched hemocytes and gill. The transcripts level DM9CP-4 circulating were decreased after...
An 8-week feeding experiment was conducted to investigate the effect of dietary histamine on growth performance, digestive physiology function and muscle quality in a hybrid grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂). Seven isoproteic (50%) isolipidic (11%) diets were prepared with various inclusion levels 0, 30, 60, 120, 240, 480 960 mg/kg (actual contents 72.33, 99.56, 138.60, 225.35, 404.12, 662.12 1245.38 mg/kg), respectively. Each diet randomly assigned triplicates...
Previously, we constructed and characterized the vaccine efficacy of attenuated S. agalactiae strain YM001 in tilapia. In this study, potential impacts on tilapia intestinal microbiota were assessed by qPCR 16S rRNA sequencing methods. The results showed that distributed unevenly different parts intestine, peaked intestine at 12 h after oral administration, then declined gradually. caused 0% mortality fish during entire experimental period, while referent HN016 100% 3 d administration....
IFN-γ is produced upon stimulation with S. aureus and may play a detrimental role during infection. However, whether hemolysins in the mechanism of production has not been fully characterized. In this study, we demonstrated that Hlb, one major , upregulated by CD56 bright NK cells from human peripheral blood mononuclear (PBMCs). Further investigation showed Hlb increased calcium influx induced phosphorylation ERK1/2. Either blocking or specifically inhibiting ERK1/2 decreased Hlb. Moreover,...