A5091216523- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Microbial Natural Products and Biosynthesis
- Advanced Proteomics Techniques and Applications
- Fungal Biology and Applications
- Genomics and Phylogenetic Studies
- Redox biology and oxidative stress
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
Fujian Agriculture and Forestry University
2016-2019
Aspergillus flavus (A. flavus) is a ubiquitous saprophytic and pathogenic fungus that produces the aflatoxin carcinogen, A. can have tremendous economic health impacts worldwide. Increasing evidence demonstrates lysine succinylation plays an important regulatory role in metabolic processes both bacterial human cells. However, little known about extent function of Here, we performed global succinylome analysis using high accuracy nano-LC-MS/MS combination with enrichment succinylated peptides...
In Aspergillus nidulans, the nitrogen metabolite repression regulator NmrA plays a major role in regulating activity of GATA transcription factor AreA during metabolism. However, function nmrA flavus has not been previously studied. Here, we report identification and functional analysis A. flavus. Our work showed that amino acid sequences are highly conserved among species protein contains canonical Rossmann fold motif. Deletion slowed growth but significantly increased conidiation sclerotia...
Summary Aspergillus flavus is a pathogenic fungus that produces carcinogenic aflatoxins, posing great threat to crops, animals and humans. Lysine acetylation one of the most important reversible post‐translational modifications plays vital regulatory role in various cellular processes. However, current information on extent function lysine aflatoxin biosynthesis A. limited. Here, global acetylome analysis was performed by peptide pre‐fractionation, pan‐acetylation antibody enrichment liquid...
Aspergillus flavus is a pathogenic fungus that produces toxic and carcinogenic aflatoxins the causative agent of aflatoxicosis. A growing body evidence indicates reversible phosphorylation plays important roles in regulating diverse functions this pathogen. However, only few phosphoproteins have been identified, which hampers our understanding A. flavus. So we performed global site-specific phosphoproteomic analysis total 598 high-confidence sites were identified 283 phosphoproteins. The...
Abstract Aflatoxin is a toxic, carcinogenic mycotoxin primarily produced by Aspergillus parasiticus and flavus . Previous studies have predicted the existence of more than 20 genes in gene cluster involved aflatoxin biosynthesis. Among these genes, aflK encodes versicolorin B synthase, which converts versiconal to B. Past research has investigated A. , but few characterized animal, plant, human pathogen To understand potential role its function was here for first time using replacement...
Abstract Protein phosphorylation, one of the most classic post-translational modification, plays a critical role in diverse cellular processes including cell cycle, growth and signal transduction pathways. However, available information phosphorylation fungi is limited. Here we provided Fungi Phosphorylation Database (FPD) that comprises high-confidence vivo phosphosites identified by MS-based proteomics various fungal species. This comprehensive database contains 62,272 non-redundant sites...