A5101574702- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Occupational and environmental lung diseases
- Heavy Metal Exposure and Toxicity
- Barrier Structure and Function Studies
- CRISPR and Genetic Engineering
- Fluoride Effects and Removal
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- 14-3-3 protein interactions
- Per- and polyfluoroalkyl substances research
- Reproductive Biology and Fertility
- Health, Environment, Cognitive Aging
- Hedgehog Signaling Pathway Studies
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Air Quality Monitoring and Forecasting
- Atmospheric chemistry and aerosols
- Microwave and Dielectric Measurement Techniques
Changhai Hospital
2025
Second Military Medical University
2025
Gansu Provincial Maternal and Child Health Hospital
2024
Chinese Center For Disease Control and Prevention
2022-2023
Baotou Medical College
2022-2023
Inner Mongolia University of Science and Technology
2022
Huazhong Agricultural University
2021
Bethune International Peace Hospital
2013-2021
Shanghai University of Medicine and Health Sciences
2021
Cangzhou Central Hospital
2021
Quercetin (QUE) is a bioactive component that belongs to the natural flavonoids group, and recent researchers found it could prevent colorectal cancer (CRC). However, exact mechanism by which QUE exerts its anti-tumor effects in CRC remains unclear. In this study, MTS assay flow cytometry were used detect of on HCT-116 cells. The results showed inhibit proliferation induce apoptosis Furthermore, whole transcriptome sequencing was employed establish microRNA (miRNA), long non-coding RNA...
Abstract Background The imbalance of expression microRNA-802 may have a significant place in tumor progression. However, the bio-function epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore pathogenesis based on microRNA-802. Methods RT-qPCR analysis was used measure level microRNA802 and YWHAZ cancer. CCK-8, colony formation, flow cytometry transwell assay were detect effects cell proliferation, apoptosis, invasion migration. Target gene prediction...
Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to develop machine learning-enabled blood-derived exosomal RNA profiling platform multi-cancer and localization. In this multi-phase, multi-center study, we analyzed from exosomes derived peripheral blood plasma in 818 participants across eight cancer types during the discovery phase. Machine learning techniques were applied identify potential pan-cancer...
Tumor dormancy is a common biological property of malignancies and leading factor in treatment failure, metastasis tumor recurrence. The present study generated mouse xenograft models by injection PKH26‑labeled SKOV3 ovarian cancer cells, which were divided into two groups: control group (SKOV3‑P tumors,) the that resistant tumors following prolonged administration cisplatin (SKOV3‑R tumors). Administration resulted inhibition growth SKOV3‑R coexisted with their host at stable size....
Objective: Circular RNAs (circRNAs) have been demonstrated in playing an important role the physiological and pathological processes (such as cancer). This paper aims to clarify of Circ_0006677 non–small-cell lung cancer (NSCLC) progression. Methods: Using clinical data vitro cell line models, we revealed tumor-suppressive circ_0006677 cancer. online bioinformatics tool, predicted target further validated its regulatory mechanisms responsible for tumor suppressor function NSCLC. Results:...
CASC8 lncRNA has been proven to be oncogenic in a variety of cancers, but its role other types cancer remains unclear. This study was investigate the retinoblastoma (Rb).RT-qPCR performed determine expression and miR34a paired Rb nontumor tissue. Overexpression cells achieved evaluate interaction between them. Methylation-specific PCR used analyze effect overexpression on MIR34A gene methylation. CCK8 assays were cell proliferation.The results showed that upregulated downregulated Moreover,...
Meningitic Escherichia coli can infiltrate the central nervous system (CNS), consequently increasing levels of proinflammatory cytokines and chemokines deteriorating integrity blood-brain barrier (BBB). Resveratrol has emerged in recent years as a compound with antioxidant anti-inflammatory properties. However, it is still unknown how resveratrol affects meningitic E. coli-induced CNS dysfunction. Here, by using vivo vitro BBB models, we demonstrated that treatment significantly inhibited...
Cervical cancer (CC) remains one of the most common and deadly malignancies among women worldwide, with exceptionally high morbidity mortality rates. The aberrant activation hedgehog pathway is intimately associated tumor development progression. Nevertheless, potential therapeutic targets within in CC have yet to be clearly identified. In this study, we conducted an in-depth investigation pathway-related genes CC, integrating single-cell sequencing data spatial transcriptomics. Utilizing a...
Objective: This study aimed to identify the novel microRNAs (miRNAs) for early diagnosis of bladder cancer. Materials and Methods: Differentially expressed miRNAs between advanced cancer were identified by differential expression analysis, using miRNA-seq data from The Cancer Genome Atlas (TCGA). optimal subset feature pathologic stage prediction was acquired Random Forest algorithm used construct a support vector machine (SVM) classifier. performance SVM classifier in predicting progression...
Objective To investigate the effect of miRNA-106b (miR-106b) on human laryngeal squamous cell carcinoma Hep-2 and TU212 cells its mechanism. Methods Hep-2 were divided into miR-106b inhibitory sequence transfected group (the experimental group), competitive negative control group) non-intervention blank group). The expression was verified by using reverse transcription quantitative polymerase chain reaction (qRT-PCR). Whether phosphatase tensin homolog (PTEN) target gene analyzed...