A5103204350- Sepsis Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Tuberculosis Research and Epidemiology
- Renal function and acid-base balance
- Microbial Natural Products and Biosynthesis
- Cardiac Ischemia and Reperfusion
- Fungal Biology and Applications
- Analytical Chemistry and Chromatography
- Phytochemical Studies and Bioactivities
- Natural Compounds in Disease Treatment
- Hormonal and reproductive studies
- Healthcare and Venom Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wound Healing and Treatments
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Microtubule and mitosis dynamics
- Sexual function and dysfunction studies
- Genetics and Neurodevelopmental Disorders
- Intensive Care Unit Cognitive Disorders
- Silk-based biomaterials and applications
Yanbian University
2024-2025
Huazhong University of Science and Technology
2019-2025
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
University of Electronic Science and Technology of China
2018-2024
Public Health Clinical Center of Chengdu
2024
Second Military Medical University
2024
Gansu University of Traditional Chinese Medicine
2024
Guangdong Provincial People's Hospital
2024
Xi'an Jiaotong University
2022
Abstract Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined. Circulating plasma exosomes mostly originating from platelets may induce vascular apoptosis myocardial dysfunction sepsis; however, their role remains unclear. This study aimed detect whether platelet-derived could promote septic shock...
Acrylamide (ACR) is a commonly used organic compound that exhibits evident neurotoxicity in humans. Our previous studies showed the mechanisms of ACR-caused included apoptosis, PERK-mediated endoplasmic reticulum stress, and autophagy, but relationships among them were still unclear. This paper investigated PERK pathway to demonstrate mechanism ACR further. Different doses set value toxicity. Then, inhibitor autophagy inhibitor, GSK2606414 3-methyladenine (3-MA), separately inhibit...
The emergence of drug resistance and limitation antifungal agents bring enormous challenges to the management Candida infection. Combination therapy is a useful way treat fungal infection, especially for those difficult-to-treat infections. In this research, we investigated interaction effects between diorcinol D (DD), an active natural product from lichen endophytic fungus fluconazole (FLC) against planktonic cells mature biofilms albicans in vitro by checkerboard microdilution time-killing...
Purpose: Age is considered a vital factor in intensive care units (ICUs) because of its association with physiological frailty, comorbidities, and immune system function. Previous studies have examined the between age prognosis patients tuberculosis (TB) or sepsis; however, ICU TB complicated by sepsis rare. This study aimed to assess sepsis. Patients Methods: Data from Public Health Clinical Center Chengdu were analyzed using multivariable Cox regression model, stratified analysis...
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Abstract The relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of patients with tuberculosis (TB) complicated by sepsis remains unclear. This study aimed explore association BAR overall patient prognosis. was a retrospective cohort TB who were admitted intensive care unit (ICU) Public Health Clinical Center Chengdu January 2019 February 2023. values in these investigated using multivariate Cox regression, stratified analysis interaction, restricted cubic...
Abstract Oxidative damage plays a critical role in many diseases of the central nervous system. This study was conducted to determine molecular mechanisms involved putative anti‐oxidative effects sevoflurane against experimental stroke. Focal cerebral ischemia performed via 1 h middle artery occlusion followed by reperfusion. At onset reperfusion, rats were subjected postconditioning with or without for h. Neurological deficit score assessed at different time points after Cerebral infarct...
Glioblastoma is the most malignant and lethal subtype brain tumors with high risk of recurrence therapeutic resistance. Emerging evidence has indicated that glycogen synthesis kinase 3 (GSK3)β plays oncogenic roles in multiple tumor types; however, underlying mechanisms remain largely unknown. It also been demonstrated p53 binding protein 1 (53BP1) a central role DNA double-strand break (DSB) repair. This study aimed to reveal significance GSK3β translocation from cytoplasm nucleus,...
Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from baseline of Ezhou-Shenzhen cohort. total 5356 subjects were included 2678 MetS controls matched by sex age (±2 years). Medians (IQRs) plasma concentrations 1.24 μg/L for cases 1.46 controls. After adjustment multiple covariates, odds ratio (OR) 95% confidence intervals...
Abstract Tuberculosis caused by Mycobacterium tuberculosis remains a serious global public health threat. Macrophage polarization is crucial for the innate immunity against M. . However, how interferes with macrophage elusive. We demonstrated here that PPE36 ( Rv2108 ) blocked M1 polarization, preventing cytokine storm, and alleviating inflammatory damage to mouse immune organs. inhibited of THP‐1 cell differentiation macrophages, reduced mitochondrial dehydrogenase activity, expression...
<title>Abstract</title> Objective The relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of patients with tuberculosis (TB) complicated by sepsis remains unclear. This study aimed explore association BAR overall patient prognosis. Methods was a retrospective cohort TB who were admitted intensive care unit (ICU) Public Health Clinical Center Chengdu January 2019 February 2023. values in these investigated using multivariate Cox regression, stratified analysis...
A Retrospective Cohort Study".Response to the first request:We acknowledge effectiveness of POSMI score as highlighted by Weng et al 1 and its superiority over APACHE IV SOFA scores in predicting sepsis mortality ICU.In our study, we chose II because their widespread use acceptance clinical setting, which allowed for standardised assessment patients.However, agree that a variety criteria, including POSMI, could improve robustness prediction.Future research will consider inclusion provide...
To explore the effect of Hei Xiaoyaosan on autophagy levels in Alzheimer's disease(AD). A total 100 4-month-old Wistar male rats were randomly selected as a blank group, and 10 taken sham operation group injected with 1 μL normal saline both sides hippocampus. The other Aβ_(1-42) solution hippocampus to replicate AD model. Fifty successfully modeled divided into model Aricatio group(0.5 mg·kg~(-1)), high, medium, low dose groups Xiaoyaosan(15.30, 7.65, 3.82 g·kg~(-1)), each group....
Various polarity chemicals exist in complex samples, such as plasma; nontargeted comprehensive analysis naturally requires multiple polar-extracted solvents; consequently, the of solvent plays a crucial role extraction efficiency analytes from samples. In present study, based on diffusion behavior and nanoconfinement effect solvents nanoconfined space, gradient confinement liquid-phase nanoextraction (PGSC-NLPNE) protocol aimed to perform one-step wide range metabolites plasma was...
Abstract Background Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved the progression of several types cancer. However, biological functions effect CDH23 expression on prognosis patients with acute myeloid leukemia (AML) are unexplored. Herein, we aim to characterize molecular AML. Methods We downloaded transcriptomic profiles clinical data from Cancer Genome Atlas Beat AML trial. The level was assessed using Gene Expression Profiling Interactive Analysis...
Objective: To explore the mechanism of androgen in improving erectile dysfunction castrated rats. Methods: Forty 8-week-old male Sprague-Dawley (SD) rats were randomly divided into 4 groups:normal control group (Group A); castration B, which castrated); intervention groups (group C and D), treated with different concentrations testosterone undecanoate orally every day at 10 mg/kg (low dose) 20 (high dose), respectively after being castrated. Animals A B given 0.9% NS instead. After 8-week...