A5044673151- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- TGF-β signaling in diseases
- Gallbladder and Bile Duct Disorders
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
Wenzhou Medical University
2021-2023
First Affiliated Hospital of Wenzhou Medical University
2021-2023
Abstract Background Ferroptosis is an important iron‐dependent form of cell death in hepatocellular carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, used to treat advanced HCC but its efficacy limited by the development drug resistance. Methods The effects DUXAP8 expression on progression were evaluated TCGA database, Kaplan‐Meier analysis, and situ hybridization analysis. Sorafenib resistant lines modeled vitro study regulation induced sorafenib. We RNA pull‐down,...
Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignant tumor with poor prognosis. This study aimed to establish novel clinical-radiomics model for predicting the prognosis of ICC after radical hepatectomy. Methods A was established 82 cases treated hepatectomy in our hospital from May 2011 December 2020. Radiomics features were extracted venous-phase and arterial-phase images computed tomography. Kaplan-Meier survival analysis generated compare overall (OS) between...
Diffuse reduction of spleen density is a novel prognostic marker for intrahepatic cholangiocarcinoma after curative resection
The current study aimed to evaluate the synergistic efficacy of lenvatinib and FOLFOX (infusional fluorouracil (FU), folinic acid, oxaliplatin) in hepatocellular carcinoma (HCC) using patient-derived xenograft (PDX) PDX-derived organotypic spheroid (XDOTS) models vivo vitro.PDX matched XDOTS originating from three patients with HCC were established. All divided into four groups treated drugs alone or combination. Tumor growth PDX was measured recorded, angiogenesis phosphorylation vascular...
Abstract Purpose It is difficult to predict the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) before radical operation. The purpose this study was explore connection between diffuse reduction spleen density on computed tomography (DROSD) and postoperative PDAC. Patients methods A total 160 PDAC who underwent surgery in First Affiliated Hospital Wenzhou Medical University were enrolled. Cox regression analysis used cast overall survival (OS) evaluate prognostic factors....
Abstract Background: The global mortality rate of pancreatic ductal adenocarcinoma (PDAC) is one the highest among all cancers, and curative chemotherapeutics are essentially nonexistent. Dipeptidyl peptidase-4 (DPP4) plays a critical role in ferroptosis, recently discovered regulated mechanism necrotic cell death that has an important function colorectal cancer. However, whether DPP4 contributes to ferroptosis cancer remained unknown. Methods: expression status was evaluated PDAC tissues...
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates among all cancers, with almost no curative chemotherapeutics. Ferroptosis is a recently recognized regulated mechanism necrotic cell death that plays an important role in cancer biology. Recent discoveries have highlighted dipeptidyl-peptidase-4 (DPP4) lipid reactive oxygen species (ROS). Large accumulation ROS causes ferroptosis cells. However, there are reports on whether it contributes to pancreatic cancer. We...