A5087607412- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Luminescence Properties of Advanced Materials
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Quantum Dots Synthesis And Properties
- Perovskite Materials and Applications
- Chalcogenide Semiconductor Thin Films
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Marine Biology and Environmental Chemistry
- Inflammatory mediators and NSAID effects
- Geology and Paleoclimatology Research
- Analog and Mixed-Signal Circuit Design
- Advancements in Semiconductor Devices and Circuit Design
- Marine Bivalve and Aquaculture Studies
- Luminescence and Fluorescent Materials
- Cancer, Lipids, and Metabolism
- Reproductive biology and impacts on aquatic species
- Genetic Syndromes and Imprinting
- Protein Tyrosine Phosphatases
- Ginseng Biological Effects and Applications
Second Military Medical University
2021-2024
Eastern Hepatobiliary Surgery Hospital
2021-2024
Institute of Microelectronics
2023-2024
Chinese Academy of Sciences
2023-2024
Chinese University of Hong Kong
2002-2024
University of Chinese Academy of Sciences
2023
Jinzhou Medical University
2013-2022
Hefei University of Technology
2014-2022
Ministry of Education of the People's Republic of China
2021
Hebei Institute of Physical Education
2021
We describe the use of a unique DNA-modification-dependent restriction endonuclease AbaSI coupled with sequencing (Aba-seq) to map high-resolution hydroxymethylome mouse E14 embryonic stem cells. The specificity enables sensitive detection 5-hydroxymethylcytosine (5hmC) at low-occupancy regions. Bioinformatic analysis suggests 5hmCs in genic regions closely follow 5mC distribution. 5hmC is generally depleted CpG islands and only enriched small set repetitive elements. A regularly spaced...
Upconversion emission dynamics have long been believed to be determined by the activator and its interaction with neighboring sensitizers. Herein this assumption is, however, shown invalid for nanostructures. We demonstrate that excitation energy migration greatly affects upconversion dynamics. "Dopant ions' spatial separation" nanostructures are designed as model systems intimate link between random nature of time behavior is unraveled theoretical modelling confirmed spectroscopically....
Background and Aims HBV‐pgRNA (pregenomic RNA) has been proposed for predicting the response of nucleos(t)ide analogue (NA) treatment, guiding discontinuation NA therapy monitoring emergence viral mutations. However, contributions to HCC remain open study. Approach Results Double‐center cohorts serum samples with undetectable HBV‐DNA (below lower limit detection) were obtained from long‐term NA‐treated (≥48 weeks) HBV‐related patients. The correlation between pgRNA concentration prognosis...
Abstract Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from third exon of transcript NM_001098801 FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. expression was downregulated and negatively correlated with patients HBV-related HCC. Furthermore, reduced proliferation,...
Dye sensitization is becoming a new dimension to highly improve the upconversion luminescence (UCL) of lanthanide-doped nanoparticles (UCNPs). However, there still lack general understanding dye-UCNPs interactions, especially confused large mismatch between inputs and outputs. By taking dye-sensitized NaYF4:Yb/Er@NaYF4:Nd UCNPs as model system, we not only revealed in-depth energy-dissipative process for UCL but also confirmed first ever experimental observation energy back transfer (EBT) in...
Abstract Studies have shown that hepatic stellate cells (HSCs) and interleukin-17a (IL-17a) play important roles in liver tumorigenesis. In addition, fibroblast activation protein-α (FAP) has been to be a key regulator of cell activation. this study, vivo vitro experiments were performed verify the promoting effects IL-17a administration, overexpression, FAP upregulation HSCs on fibrosis The cleavage under targets & release using nuclease (CUT&RUN) technique was used binding status...
Abstract The long noncoding RNA component of mitochondrial RNA‐processing endoribonuclease (lncRNA RMRP) plays an important role in tumor development. In the present study, we determined regulatory function RMRP non–small‐cell lung cancer (NSCLC). NSCLC tissues and adjacent nontumor were collected for study. expression was detected by quantitative real time‐PCR cell lines. functional validation experiments performed to determine on progression. addition, identified downstream target miRNAs...
Various liver diseases caused by damage seriously affect people's health. The purpose of this study was to clarify the effects and mechanisms carnitine palmitoyltransferase 1 (Cpt1a) on oxidative stress inflammation in injury. It found that expression Cpt1a mRNA upregulated a model injury mice. Thus, overexpression increased reactive oxygen species (ROS) production malondialdehyde (MDA) levels reduced superoxide dismutase (SOD), glutathione (GSH), peroxidase (GSH-px) an vitro also shown...
Abstract DNA methylation plays a pivotal role in the development and progression of tumors. However, studies focused on dynamic changes hepatocellular carcinoma (HCC) are rare. To systematically illustrate alternation from premalignant to early-stage liver cancer with same genetic background, this study enrolled 5 HBV-related patients preceded cirrhosis, pathologically identified as HCC dysplastic nodules. Liver fibrosis tissues, nodules early tissues these were used measure methylation....
Composition-controllable ternary CdSe(x)S(1-x) quantum dots (QDs) with multiple emission colors were obtained via a hot-injection-like method at relatively low injection temperature (230 ° C) in octadecene. Then highly fluorescent CdSe(x)S(1-x)/ZnS core/shell (CS) QDs synthesized by facile single-molecular precursor approach. The yield of the resulting green (λ(em) = 523 nm), yellow 565 nm) and red 621 CS toluene reached up to 85%, 55% 39%, respectively. Moreover, white light-emitting diode...
Abstract Background Induced pluripotent mesenchymal stem cells (iPMSCs) are novel candidates for drug screening, regenerative medicine, and cell therapy. However, introduction of transcription factor encoding genes induced (iPSC) generation which could be used to generate is accompanied by the risk insertional mutations in target genome. Methods We demonstrate a method using an inactivated viral particle package deliver four purified recombinant Yamanaka factors (Sox2, Oct4, Klf4, c-Myc)...
Abstract Upconversion emission dynamics have long been believed to be determined by the activator and its interaction with neighboring sensitizers. Herein this assumption is, however, shown invalid for nanostructures. We demonstrate that excitation energy migration greatly affects upconversion dynamics. “Dopant ions’ spatial separation” nanostructures are designed as model systems intimate link between random nature of time behavior is unraveled theoretical modelling confirmed...
The management of patients with glioblastoma multiforme is difficult. Poor results have led to a search for novel therapeutic approaches. Gene therapy that could be both anti-invasive and antiangiogenic would ideal. In this study, we constructed the recombinant adenoviral vector Ad-CALR/MAGE-A3 evaluated its antitumor effects on in vitro vivo.In CALR MAGE-A3 genes were delivered cell line U87, using adenovirus (Ad-CALR/MAGE-A3). U87 cells transfected Ad-green fluorescent protein identify...
In light of the predicament concerning small gain and narrow frequency range miniature antennas, this paper employs implementation a fractal repeating array structure double-layer folding antenna structure. Through these measures, is endowed with high an expansive range, all within its diminutive size. The presents exquisite high-gain flexible multi-band antenna, utilizing dielectric substrate composed material polyimide, thickness merely 0.1 mm. bestows feathery mass 4 mg upon enabling it...
Abstract Vitellogenin ( VTG ), the precursor of yolk protein, plays an important role during vitellogenesis and oogenesis. However, little is known about vitellogenin gene in marine bivalves. We cloned full‐length cDNA C hlamys farreri Cf‐vtg ) using a homologous cloning strategy rapid amplification ends. The consisted 7604 nucleotides with open reading frame encoding 2296 amino acid residues. deduced sequence shared high similarity other species, particularly N‐terminal region. analyzed...
Chronic kidney disease (CKD) is an intractable in which inflammation and oxidative stress are important. In the present study, effect of simvastatin on induced by angiotensin II (Ang II) human mesangial cells (HMCs) its corresponding mechanism was examined. vitro experiment, HMCs were pretreated either without additives (control group) or with at different concentrations (0, 0.1, 1 10 µM) for h then stimulated Ang (1 24 h. Following stimulation, collected analysis using quantitative...
Lung cancer is the leading cause of cancer-related mortality around world. This malignancy has a 5-year survival rate 21%, because most patients are diagnosed in middle or late stage disease when local metastasis and tumor invasion have already progressed. Therefore, investigation pathogenesis lung an issue crucial importance. MicroRNAs (miRNAs) seem to be involved evolution development cancer. MicroRNA-608 likely downregulated tissues. Regarding this, current study determination fundamental...
Gypenosides (Gyps) are triterpenoid saponins contained in an extract from Gynostemma pentaphyllum Makino and reported to induce apoptosis human hepatoma cells through Ca2+-implicated endoplasmic reticulum (ER) stress mitochondria-dependent pathways. The mechanism underlying the Gyp-increased intracellular Ca2+ concentration ([Ca2+]i) is unclear. Here, we examined Gyp-induced necrosis HepG2 cells. apoptotic cell death was accompanied by a sustained increase [Ca2+]i level. level partly...
The purpose of this paper is to study the efficacy applying stereotactic navigation guidance nasopharyngectomy via a minimally invasive transnasal approach as compared with conventional open transfacial approaches. nasopharynx centre anterior skull base, which remote from surface facial skeleton. It well known that there are several surgical approaches for access resect tumours nasopharynx. However, techniques have been associated much morbidity and only provide to, identification of,...